schliessen

Filtern

 

Bibliotheken

Characterization of 47 MHC class I sequences in Filipino cynomolgus macaques

Cynomolgus macaques ( Macaca fascicularis ) provide increasingly common models for infectious disease research. Several geographically distinct populations of these macaques from Southeast Asia and the Indian Ocean island of Mauritius are available for pathogenesis studies. Though host genetics may... Full description

Journal Title: Immunogenetics 2009, Vol.61(3), pp.177-187
Main Author: Campbell, Kevin
Other Authors: Detmer, Ann , Karl, Julie , Wiseman, Roger , Blasky, Alex , Hughes, Austin , Bimber, Benjamin , O’Connor, Shelby , O’Connor, David
Format: Electronic Article Electronic Article
Language: English
Subjects:
MHC
SIV
ID: ISSN: 0093-7711 ; E-ISSN: 1432-1211 ; DOI: 10.1007/s00251-008-0351-x
Link: http://dx.doi.org/10.1007/s00251-008-0351-x
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: springer_jour10.1007/s00251-008-0351-x
title: Characterization of 47 MHC class I sequences in Filipino cynomolgus macaques
format: Article
creator:
  • Campbell, Kevin
  • Detmer, Ann
  • Karl, Julie
  • Wiseman, Roger
  • Blasky, Alex
  • Hughes, Austin
  • Bimber, Benjamin
  • O’Connor, Shelby
  • O’Connor, David
subjects:
  • MHC
  • Filipino
  • Macaca fascicularis
  • SIV
ispartof: Immunogenetics, 2009, Vol.61(3), pp.177-187
description: Cynomolgus macaques ( Macaca fascicularis ) provide increasingly common models for infectious disease research. Several geographically distinct populations of these macaques from Southeast Asia and the Indian Ocean island of Mauritius are available for pathogenesis studies. Though host genetics may profoundly impact results of such studies, similarities and differences between populations are often overlooked. In this study we identified 47 full-length MHC class I nucleotide sequences in 16 cynomolgus macaques of Filipino origin. The majority of MHC class I sequences characterized (39 of 47) were unique to this regional population. However, we discovered eight sequences with perfect identity and six sequences with close similarity to previously defined MHC class I sequences from other macaque populations. We identified two ancestral MHC haplotypes that appear to be shared between Filipino and Mauritian cynomolgus macaques, notably a Mafa-B haplotype that has previously been shown to protect Mauritian cynomolgus macaques against challenge with a simian/human immunodeficiency virus, SHIV 89.6P . We also identified a Filipino cynomolgus macaque MHC class I sequence for which the predicted protein sequence differs from Mamu-B*17 by a single amino acid. This is important because Mamu-B*17 is strongly associated with protection against simian immunodeficiency virus (SIV) challenge in Indian rhesus macaques. These findings have implications for the evolutionary history of Filipino cynomolgus macaques as well as for the use of this model in SIV/SHIV research protocols.
language: eng
source:
identifier: ISSN: 0093-7711 ; E-ISSN: 1432-1211 ; DOI: 10.1007/s00251-008-0351-x
fulltext: fulltext
issn:
  • 1432-1211
  • 14321211
  • 0093-7711
  • 00937711
url: Link


@attributes
ID1165203442
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1007/s00251-008-0351-x
sourceidspringer_jour
recordidTN_springer_jour10.1007/s00251-008-0351-x
sourcesystemOther
pqid66999853
galeid229411004
display
typearticle
titleCharacterization of 47 MHC class I sequences in Filipino cynomolgus macaques
creatorCampbell, Kevin ; Detmer, Ann ; Karl, Julie ; Wiseman, Roger ; Blasky, Alex ; Hughes, Austin ; Bimber, Benjamin ; O’Connor, Shelby ; O’Connor, David
ispartofImmunogenetics, 2009, Vol.61(3), pp.177-187
identifier
subjectMHC ; Filipino ; Macaca fascicularis ; SIV
descriptionCynomolgus macaques ( Macaca fascicularis ) provide increasingly common models for infectious disease research. Several geographically distinct populations of these macaques from Southeast Asia and the Indian Ocean island of Mauritius are available for pathogenesis studies. Though host genetics may profoundly impact results of such studies, similarities and differences between populations are often overlooked. In this study we identified 47 full-length MHC class I nucleotide sequences in 16 cynomolgus macaques of Filipino origin. The majority of MHC class I sequences characterized (39 of 47) were unique to this regional population. However, we discovered eight sequences with perfect identity and six sequences with close similarity to previously defined MHC class I sequences from other macaque populations. We identified two ancestral MHC haplotypes that appear to be shared between Filipino and Mauritian cynomolgus macaques, notably a Mafa-B haplotype that has previously been shown to protect Mauritian cynomolgus macaques against challenge with a simian/human immunodeficiency virus, SHIV 89.6P . We also identified a Filipino cynomolgus macaque MHC class I sequence for which the predicted protein sequence differs from Mamu-B*17 by a single amino acid. This is important because Mamu-B*17 is strongly associated with protection against simian immunodeficiency virus (SIV) challenge in Indian rhesus macaques. These findings have implications for the evolutionary history of Filipino cynomolgus macaques as well as for the use of this model in SIV/SHIV research protocols.
languageeng
source
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://dx.doi.org/10.1007/s00251-008-0351-x$$EView_full_text_in_Springer_(Subscribers_only)
search
creatorcontrib
0Campbell, Kevin, J.
1Detmer, Ann, M.
2Karl, Julie, A.
3Wiseman, Roger, W.
4Blasky, Alex, J.
5Hughes, Austin, L.
6Bimber, Benjamin, N.
7O’Connor, Shelby, L.
8O’Connor, David, H.
titleCharacterization of 47 MHC class I sequences in Filipino cynomolgus macaques
descriptionCynomolgus macaques ( Macaca fascicularis ) provide increasingly common models for infectious disease research. Several geographically distinct populations of these macaques from Southeast Asia and the Indian Ocean island of Mauritius are available for pathogenesis studies. Though host genetics may profoundly impact results of such studies, similarities and differences between populations are often overlooked. In this study we identified 47 full-length MHC class I nucleotide sequences in 16 cynomolgus macaques of Filipino origin. The majority of MHC class I sequences characterized (39 of 47) were unique to this regional population. However, we discovered eight sequences with perfect identity and six sequences with close similarity to previously defined MHC class I sequences from other macaque populations. We identified two ancestral MHC haplotypes that appear to be shared between Filipino and Mauritian cynomolgus macaques, notably a Mafa-B haplotype that has previously been shown to protect Mauritian cynomolgus macaques against challenge with a simian/human immunodeficiency virus, SHIV 89.6P . We also identified a Filipino cynomolgus macaque MHC class I sequence for which the predicted protein sequence differs from Mamu-B*17 by a single amino acid. This is important because Mamu-B*17 is strongly associated with protection against simian immunodeficiency virus (SIV) challenge in Indian rhesus macaques. These findings have implications for the evolutionary history of Filipino cynomolgus macaques as well as for the use of this model in SIV/SHIV research protocols.
subject
0MHC
1Filipino
2Macaca fascicularis
3SIV
general
010.1007/s00251-008-0351-x
1English
2Springer Science & Business Media B.V.
3SpringerLink
sourceidspringer_jour
recordidspringer_jour10.1007/s00251-008-0351-x
issn
01432-1211
114321211
20093-7711
300937711
rsrctypearticle
creationdate2009
addtitleImmunogenetics
searchscopespringer_journals_complete
scopespringer_journals_complete
lsr30VSR-Enriched:[pqid, pages, galeid]
sort
titleCharacterization of 47 MHC class I sequences in Filipino cynomolgus macaques
authorCampbell, Kevin ; Detmer, Ann ; Karl, Julie ; Wiseman, Roger ; Blasky, Alex ; Hughes, Austin ; Bimber, Benjamin ; O’Connor, Shelby ; O’Connor, David
creationdate20090300
facets
frbrgroupid7559563000526397639
frbrtype5
languageeng
creationdate2009
topic
0Mhc
1Filipino
2Macaca Fascicularis
3Siv
collectionSpringerLink
prefilterarticles
rsrctypearticles
creatorcontrib
0Campbell, Kevin
1Detmer, Ann
2Karl, Julie
3Wiseman, Roger
4Blasky, Alex
5Hughes, Austin
6Bimber, Benjamin
7O’Connor, Shelby
8O’Connor, David
jtitleImmunogenetics
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Campbell
1Detmer
2Karl
3Wiseman
4Blasky
5Hughes
6Bimber
7O’Connor
aufirst
0Kevin
1J.
2Ann
3M.
4Julie
5A.
6Roger
7W.
8Alex
9Austin
10L.
11Benjamin
12N.
13Shelby
14David
15H.
au
0Campbell, Kevin
1Detmer, Ann
2Karl, Julie
3Wiseman, Roger
4Blasky, Alex
5Hughes, Austin
6Bimber, Benjamin
7O’Connor, Shelby
8O’Connor, David
atitleCharacterization of 47 MHC class I sequences in Filipino cynomolgus macaques
jtitleImmunogenetics
stitleImmunogenetics
risdate200903
volume61
issue3
spage177
epage187
issn0093-7711
eissn1432-1211
genrearticle
ristypeJOUR
abstractCynomolgus macaques ( Macaca fascicularis ) provide increasingly common models for infectious disease research. Several geographically distinct populations of these macaques from Southeast Asia and the Indian Ocean island of Mauritius are available for pathogenesis studies. Though host genetics may profoundly impact results of such studies, similarities and differences between populations are often overlooked. In this study we identified 47 full-length MHC class I nucleotide sequences in 16 cynomolgus macaques of Filipino origin. The majority of MHC class I sequences characterized (39 of 47) were unique to this regional population. However, we discovered eight sequences with perfect identity and six sequences with close similarity to previously defined MHC class I sequences from other macaque populations. We identified two ancestral MHC haplotypes that appear to be shared between Filipino and Mauritian cynomolgus macaques, notably a Mafa-B haplotype that has previously been shown to protect Mauritian cynomolgus macaques against challenge with a simian/human immunodeficiency virus, SHIV 89.6P . We also identified a Filipino cynomolgus macaque MHC class I sequence for which the predicted protein sequence differs from Mamu-B*17 by a single amino acid. This is important because Mamu-B*17 is strongly associated with protection against simian immunodeficiency virus (SIV) challenge in Indian rhesus macaques. These findings have implications for the evolutionary history of Filipino cynomolgus macaques as well as for the use of this model in SIV/SHIV research protocols.
copBerlin/Heidelberg
pubSpringer-Verlag
doi10.1007/s00251-008-0351-x
pages177-187
date2009-03