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Ultrasound-detected joint inflammation and B cell count: related variables for rituximab-treated RA patients?

This cross-sectional observational study aimed to explore the relationship between B cell count and ultrasound (US)-detected synovitis, in patients with rheumatoid arthritis treated with rituximab. Thirty-seven consecutive RA patients treated with RTX were recruited for the study. The patients under... Full description

Journal Title: Rheumatology International 2016, Vol.36(6), pp.793-797
Main Author: Valor, Lara
Other Authors: Martínez-Estupiñán, Lina , Janta, Iustina , Nieto, Juan , Ovalles-Bonilla, Juan , González-Fernández, Carlos , Rio, Tamara , Hernández-Flórez, Diana , Monteagudo, Indalecio , López-Longo, Francisco , Naredo, Esperanza
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0172-8172 ; E-ISSN: 1437-160X ; DOI: 10.1007/s00296-016-3477-4
Link: http://dx.doi.org/10.1007/s00296-016-3477-4
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recordid: springer_jour10.1007/s00296-016-3477-4
title: Ultrasound-detected joint inflammation and B cell count: related variables for rituximab-treated RA patients?
format: Article
creator:
  • Valor, Lara
  • Martínez-Estupiñán, Lina
  • Janta, Iustina
  • Nieto, Juan
  • Ovalles-Bonilla, Juan
  • González-Fernández, Carlos
  • Rio, Tamara
  • Hernández-Flórez, Diana
  • Monteagudo, Indalecio
  • López-Longo, Francisco
  • Naredo, Esperanza
subjects:
  • B cells
  • Rheumatoid arthritis
  • Ultrasonography
  • Biological therapies
  • DMARDs
ispartof: Rheumatology International, 2016, Vol.36(6), pp.793-797
description: This cross-sectional observational study aimed to explore the relationship between B cell count and ultrasound (US)-detected synovitis, in patients with rheumatoid arthritis treated with rituximab. Thirty-seven consecutive RA patients treated with RTX were recruited for the study. The patients underwent clinical [i.e., Disease Activity Score 28 joints (DAS28)], laboratory, and US assessment of 12 joints. Each joint was semiquantitatively (0–3) scored on B-mode and power Doppler mode. The scores were summed, and a global index was created for BM (BMS) and PD scores (PDI) synovitis. BM subclinical synovitis was evident in all patients, with PD synovial signal detected in 16 patients (43.2 %). No correlation was found between DAS28 and US scores. B cells were detected in 27 (72.9 %) patients, but there was no association in the mean B cell count and disease activity as measured by DAS28 (DAS28  2.6 = 49.45, p  = 0.52) and PDI score (PDI  1 = 35.44, p  = 0.54). There was no correlation between the B cell count and DAS28, BMS, and PDI ( r  = 0.020, p  = 0.907; r  = −0.151, p  = 0.371; r  = −0.099, p  = 0.558, respectively). In RTX-treated RA patients, no relationship could be established between US-detected synovitis and peripheral blood B cell count.
language: eng
source:
identifier: ISSN: 0172-8172 ; E-ISSN: 1437-160X ; DOI: 10.1007/s00296-016-3477-4
fulltext: fulltext
issn:
  • 1437-160X
  • 1437160X
  • 0172-8172
  • 01728172
url: Link


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titleUltrasound-detected joint inflammation and B cell count: related variables for rituximab-treated RA patients?
creatorValor, Lara ; Martínez-Estupiñán, Lina ; Janta, Iustina ; Nieto, Juan ; Ovalles-Bonilla, Juan ; González-Fernández, Carlos ; Rio, Tamara ; Hernández-Flórez, Diana ; Monteagudo, Indalecio ; López-Longo, Francisco ; Naredo, Esperanza
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subjectB cells ; Rheumatoid arthritis ; Ultrasonography ; Biological therapies ; DMARDs
descriptionThis cross-sectional observational study aimed to explore the relationship between B cell count and ultrasound (US)-detected synovitis, in patients with rheumatoid arthritis treated with rituximab. Thirty-seven consecutive RA patients treated with RTX were recruited for the study. The patients underwent clinical [i.e., Disease Activity Score 28 joints (DAS28)], laboratory, and US assessment of 12 joints. Each joint was semiquantitatively (0–3) scored on B-mode and power Doppler mode. The scores were summed, and a global index was created for BM (BMS) and PD scores (PDI) synovitis. BM subclinical synovitis was evident in all patients, with PD synovial signal detected in 16 patients (43.2 %). No correlation was found between DAS28 and US scores. B cells were detected in 27 (72.9 %) patients, but there was no association in the mean B cell count and disease activity as measured by DAS28 (DAS28 < 2.6 = 34.53, DAS28 > 2.6 = 49.45, p  = 0.52) and PDI score (PDI < 1 = 49.48, PDI > 1 = 35.44, p  = 0.54). There was no correlation between the B cell count and DAS28, BMS, and PDI ( r  = 0.020, p  = 0.907; r  = −0.151, p  = 0.371; r  = −0.099, p  = 0.558, respectively). In RTX-treated RA patients, no relationship could be established between US-detected synovitis and peripheral blood B cell count.
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titleUltrasound-detected joint inflammation and B cell count: related variables for rituximab-treated RA patients?
descriptionThis cross-sectional observational study aimed to explore the relationship between B cell count and ultrasound (US)-detected synovitis, in patients with rheumatoid arthritis treated with rituximab. Thirty-seven consecutive RA patients treated with RTX were recruited for the study. The patients underwent clinical [i.e., Disease Activity Score 28 joints (DAS28)], laboratory, and US assessment of 12 joints. Each joint was semiquantitatively (0–3) scored on B-mode and power Doppler mode. The scores were summed, and a global index was created for BM (BMS) and PD scores (PDI) synovitis. BM subclinical synovitis was evident in all patients, with PD synovial signal detected in 16 patients (43.2 %). No correlation was found between DAS28 and US scores. B cells were detected in 27 (72.9 %) patients, but there was no association in the mean B cell count and disease activity as measured by DAS28 (DAS28 < 2.6 = 34.53, DAS28 > 2.6 = 49.45, p  = 0.52) and PDI score (PDI < 1 = 49.48, PDI > 1 = 35.44, p  = 0.54). There was no correlation between the B cell count and DAS28, BMS, and PDI ( r  = 0.020, p  = 0.907; r  = −0.151, p  = 0.371; r  = −0.099, p  = 0.558, respectively). In RTX-treated RA patients, no relationship could be established between US-detected synovitis and peripheral blood B cell count.
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titleUltrasound-detected joint inflammation and B cell count: related variables for rituximab-treated RA patients?
authorValor, Lara ; Martínez-Estupiñán, Lina ; Janta, Iustina ; Nieto, Juan ; Ovalles-Bonilla, Juan ; González-Fernández, Carlos ; Rio, Tamara ; Hernández-Flórez, Diana ; Monteagudo, Indalecio ; López-Longo, Francisco ; Naredo, Esperanza
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abstractThis cross-sectional observational study aimed to explore the relationship between B cell count and ultrasound (US)-detected synovitis, in patients with rheumatoid arthritis treated with rituximab. Thirty-seven consecutive RA patients treated with RTX were recruited for the study. The patients underwent clinical [i.e., Disease Activity Score 28 joints (DAS28)], laboratory, and US assessment of 12 joints. Each joint was semiquantitatively (0–3) scored on B-mode and power Doppler mode. The scores were summed, and a global index was created for BM (BMS) and PD scores (PDI) synovitis. BM subclinical synovitis was evident in all patients, with PD synovial signal detected in 16 patients (43.2 %). No correlation was found between DAS28 and US scores. B cells were detected in 27 (72.9 %) patients, but there was no association in the mean B cell count and disease activity as measured by DAS28 (DAS28 < 2.6 = 34.53, DAS28 > 2.6 = 49.45, p  = 0.52) and PDI score (PDI < 1 = 49.48, PDI > 1 = 35.44, p  = 0.54). There was no correlation between the B cell count and DAS28, BMS, and PDI ( r  = 0.020, p  = 0.907; r  = −0.151, p  = 0.371; r  = −0.099, p  = 0.558, respectively). In RTX-treated RA patients, no relationship could be established between US-detected synovitis and peripheral blood B cell count.
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pubSpringer Berlin Heidelberg
doi10.1007/s00296-016-3477-4
pages793-797
date2016-06