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T1rho and T2 relaxation times for lumbar disc degeneration: an in vivo comparative study at 3.0-Tesla MRI

Byline: Yi-Xiang J. Wang (1), Feng Zhao (1), James F. Griffith (1), Greta S. P. Mok (2), Jason C. S. Leung (3), Anil T. Ahuja (1), Jing Yuan (1) Keywords: Magnetic resonance imaging; Disc; Degeneration; Nucleus pulposus; Annulus fibrosus Abstract: Objective To determine the relative performance of T... Full description

Journal Title: European Radiology 2013, Vol.23(1), pp.228-234
Main Author: Wang, Yi-Xiang
Other Authors: Zhao, Feng , Griffith, James , Mok, Greta , Leung, Jason , Ahuja, Anil , Yuan, Jing
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0938-7994 ; E-ISSN: 1432-1084 ; DOI: 10.1007/s00330-012-2591-2
Link: http://dx.doi.org/10.1007/s00330-012-2591-2
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recordid: springer_jour10.1007/s00330-012-2591-2
title: T1rho and T2 relaxation times for lumbar disc degeneration: an in vivo comparative study at 3.0-Tesla MRI
format: Article
creator:
  • Wang, Yi-Xiang
  • Zhao, Feng
  • Griffith, James
  • Mok, Greta
  • Leung, Jason
  • Ahuja, Anil
  • Yuan, Jing
subjects:
  • Magnetic resonance imaging
  • Disc
  • Degeneration
  • Nucleus pulposus
  • Annulus fibrosus
ispartof: European Radiology, 2013, Vol.23(1), pp.228-234
description: Byline: Yi-Xiang J. Wang (1), Feng Zhao (1), James F. Griffith (1), Greta S. P. Mok (2), Jason C. S. Leung (3), Anil T. Ahuja (1), Jing Yuan (1) Keywords: Magnetic resonance imaging; Disc; Degeneration; Nucleus pulposus; Annulus fibrosus Abstract: Objective To determine the relative performance of T1rho and T2 relaxation times in disc degeneration assessment. Methods Lumbar sagittal MRI was performed at 3T in 52 subjects. With a spin-lock frequency of 500 Hz, T1rho was measured using a rotary echo spin-lock pulse embedded in a three-dimensional (3D) balanced fast field echo sequence. A multi-echo TSE sequence was used for T2 mapping. Regions of interest (ROIs) were drawn over the T1rho and T2 maps, including nucleus pulposus (NP) and annulus fibrosus (AF). Eight- and five-level disc degeneration semi-quantitative grading was performed. Results For NP, T1rho and T2 decreased quadratically with disc degeneration grades and had no significant trend difference (P=0.40). For AF, T1rho decreased linearly as the disc degenerated and had a slope of -3.02 and -4.56 for eight- and five-level gradings respectively while the slopes for T2 values were -1.43 and -1.84 respectively, being significantly flatter than those of T1rho (P
language: eng
source:
identifier: ISSN: 0938-7994 ; E-ISSN: 1432-1084 ; DOI: 10.1007/s00330-012-2591-2
fulltext: fulltext
issn:
  • 1432-1084
  • 14321084
  • 0938-7994
  • 09387994
url: Link


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titleT1rho and T2 relaxation times for lumbar disc degeneration: an in vivo comparative study at 3.0-Tesla MRI
creatorWang, Yi-Xiang ; Zhao, Feng ; Griffith, James ; Mok, Greta ; Leung, Jason ; Ahuja, Anil ; Yuan, Jing
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subjectMagnetic resonance imaging ; Disc ; Degeneration ; Nucleus pulposus ; Annulus fibrosus
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descriptionByline: Yi-Xiang J. Wang (1), Feng Zhao (1), James F. Griffith (1), Greta S. P. Mok (2), Jason C. S. Leung (3), Anil T. Ahuja (1), Jing Yuan (1) Keywords: Magnetic resonance imaging; Disc; Degeneration; Nucleus pulposus; Annulus fibrosus Abstract: Objective To determine the relative performance of T1rho and T2 relaxation times in disc degeneration assessment. Methods Lumbar sagittal MRI was performed at 3T in 52 subjects. With a spin-lock frequency of 500 Hz, T1rho was measured using a rotary echo spin-lock pulse embedded in a three-dimensional (3D) balanced fast field echo sequence. A multi-echo TSE sequence was used for T2 mapping. Regions of interest (ROIs) were drawn over the T1rho and T2 maps, including nucleus pulposus (NP) and annulus fibrosus (AF). Eight- and five-level disc degeneration semi-quantitative grading was performed. Results For NP, T1rho and T2 decreased quadratically with disc degeneration grades and had no significant trend difference (P=0.40). For AF, T1rho decreased linearly as the disc degenerated and had a slope of -3.02 and -4.56 for eight- and five-level gradings respectively while the slopes for T2 values were -1.43 and -1.84 respectively, being significantly flatter than those of T1rho (P<0.001). There was no significant difference in T1rho and T2 values for both NP and AF among discs of grade 5/8 to 8/8 degeneration. Conclusion T1rho is better suited for evaluating AF in degenerated disc than T2. In NP, T1rho and T2 decrease in a similar pattern following disc degeneration. Key Points aC/ MRI provides unique information about the lumbar disc nucleus pulposus aC/ Both T1rho and T2 relaxation times decrease similarly following disc degeneration aC/ AF T1rho relaxation times decrease progressively faster than T2 relaxation times aC/ T2 and T1rho relaxation times do not reduce further by disc-space narrowing Author Affiliation: (1) Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China (2) Department of Electrical and Electronics Engineering, University of Macau, Taipa, Macau SAR, China (3) Jockey Club Centre for Osteoporosis Care and Control, School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China Article History: Registration Date: 11/07/2012 Received Date: 21/04/2012 Accepted Date: 29/06/2012 Online Date: 04/08/2012 Article note: Electronic supplementary material The online version of this article (doi: 10.1007/s00330-012-2591-2) contains supplementary material, which is available to authorised users.
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