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Combined gadoxetic acid and gadofosveset enhanced liver MRI for detection and characterization of liver metastases

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00330-016-4375-6 Byline: Peter Bannas (1,2), Candice A. Bookwalter (1), Tim Ziemlewicz (1), Utaroh Motosugi (1,3), Alejandro Munoz del Rio (1), Theodora A. Potretzke (... Full description

Journal Title: European Radiology 2017, Vol.27(1), pp.32-40
Main Author: Bannas, Peter
Other Authors: Bookwalter, Candice , Ziemlewicz, Tim , Motosugi, Utaroh , Munoz del Rio, Alejandro , Potretzke, Theodora , Nagle, Scott , Reeder, Scott
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0938-7994 ; E-ISSN: 1432-1084 ; DOI: 10.1007/s00330-016-4375-6
Link: http://dx.doi.org/10.1007/s00330-016-4375-6
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recordid: springer_jour10.1007/s00330-016-4375-6
title: Combined gadoxetic acid and gadofosveset enhanced liver MRI for detection and characterization of liver metastases
format: Article
creator:
  • Bannas, Peter
  • Bookwalter, Candice
  • Ziemlewicz, Tim
  • Motosugi, Utaroh
  • Munoz del Rio, Alejandro
  • Potretzke, Theodora
  • Nagle, Scott
  • Reeder, Scott
subjects:
  • Magnetic resonance imaging
  • Liver
  • Metastases
  • Gadoxetic acid
  • Gadofosveset trisodium
ispartof: European Radiology, 2017, Vol.27(1), pp.32-40
description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00330-016-4375-6 Byline: Peter Bannas (1,2), Candice A. Bookwalter (1), Tim Ziemlewicz (1), Utaroh Motosugi (1,3), Alejandro Munoz del Rio (1), Theodora A. Potretzke (1), Scott K. Nagle (1,4,5), Scott B. Reeder (1,4,6,7,8) Keywords: Magnetic resonance imaging; Liver; Metastases; Gadoxetic acid; Gadofosveset trisodium Abstract: Purpose To compare gadoxetic acid alone and combined gadoxetic acid/gadofosveset trisodium-enhanced liver MRI for detection of metastases and differentiation of metastases from haemangiomas. Methods Ninety-one patients underwent gadoxetic acid-enhanced liver MRI before and after additional injection of gadofosveset. First, two readers retrospectively identified metastases on gadoxetic acid alone enhanced delayed hepatobiliary phase T1-weighted images together with all other MR images (dynamic images, T2-weighted images, diffusion-weighted images). Second, readers assessed additional T1-weighted images obtained after administration of gadofosveset trisodium. For both interpretations, readers rated lesion conspicuity and confidence in differentiating metastases from haemangiomas. Results were compared using alternative free-response receiver-operating characteristic (AFROC) and conventional ROC methods. Histology and follow-up served as reference standard. Results There were 145 metastases and 16 haemangiomas. Both readers detected more metastases using combined gadoxetic acid/gadofosveset (reader 1=130 reader 2=124) compared to gadoxetic acid alone (reader 1=104 reader 2=103). Sensitivity of combined gadoxetic acid/gadofosveset (reader 1=90 % reader 2=86 %) was higher than that of gadoxetic acid alone (reader 1=72 % reader 2=71 %, both P
language: eng
source:
identifier: ISSN: 0938-7994 ; E-ISSN: 1432-1084 ; DOI: 10.1007/s00330-016-4375-6
fulltext: fulltext
issn:
  • 1432-1084
  • 14321084
  • 0938-7994
  • 09387994
url: Link


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titleCombined gadoxetic acid and gadofosveset enhanced liver MRI for detection and characterization of liver metastases
creatorBannas, Peter ; Bookwalter, Candice ; Ziemlewicz, Tim ; Motosugi, Utaroh ; Munoz del Rio, Alejandro ; Potretzke, Theodora ; Nagle, Scott ; Reeder, Scott
ispartofEuropean Radiology, 2017, Vol.27(1), pp.32-40
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subjectMagnetic resonance imaging ; Liver ; Metastases ; Gadoxetic acid ; Gadofosveset trisodium
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descriptionTo access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00330-016-4375-6 Byline: Peter Bannas (1,2), Candice A. Bookwalter (1), Tim Ziemlewicz (1), Utaroh Motosugi (1,3), Alejandro Munoz del Rio (1), Theodora A. Potretzke (1), Scott K. Nagle (1,4,5), Scott B. Reeder (1,4,6,7,8) Keywords: Magnetic resonance imaging; Liver; Metastases; Gadoxetic acid; Gadofosveset trisodium Abstract: Purpose To compare gadoxetic acid alone and combined gadoxetic acid/gadofosveset trisodium-enhanced liver MRI for detection of metastases and differentiation of metastases from haemangiomas. Methods Ninety-one patients underwent gadoxetic acid-enhanced liver MRI before and after additional injection of gadofosveset. First, two readers retrospectively identified metastases on gadoxetic acid alone enhanced delayed hepatobiliary phase T1-weighted images together with all other MR images (dynamic images, T2-weighted images, diffusion-weighted images). Second, readers assessed additional T1-weighted images obtained after administration of gadofosveset trisodium. For both interpretations, readers rated lesion conspicuity and confidence in differentiating metastases from haemangiomas. Results were compared using alternative free-response receiver-operating characteristic (AFROC) and conventional ROC methods. Histology and follow-up served as reference standard. Results There were 145 metastases and 16 haemangiomas. Both readers detected more metastases using combined gadoxetic acid/gadofosveset (reader 1=130 reader 2=124) compared to gadoxetic acid alone (reader 1=104 reader 2=103). Sensitivity of combined gadoxetic acid/gadofosveset (reader 1=90 % reader 2=86 %) was higher than that of gadoxetic acid alone (reader 1=72 % reader 2=71 %, both P<0.01). AFROC-AUC was higher for the combined technique (0.92 vs. 0.86, P<0.001). Sensitivity for correct differentiation of metastases from haemangiomas was higher for the combined technique (reader 1=98 % reader 2=99 % vs. reader 1=86 % reader 2=91 %, both P<0.01). ROC-AUC was significantly higher for the combined technique (reader 1=1.00 reader 2=1.00 vs. reader 1=0.87 reader 2=0.92, both P<0.01). Conclusion Combined gadoxetic acid/gadofosveset-enhanced MRI improves detection and characterization of liver metastases compared to gadoxetic acid alone. Key Points acents Combined gadoxetic acid and gadofosveset-enhanced liver MRI significantly improves detection of metastases. acents The combined enhancement technique improves the accuracy to differentiate metastases from haemangiomas. acents Prospective studies need to determine the clinical impact of the combined technique Author Affiliation: (1) Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA (2) Department of Radiology, University Hospital, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany (3) Department of Radiology, University of Yamanashi, Yamanashi, Japan (4) Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA (5) Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA (6) Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA (7) Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA (8) Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, USA Article History: Registration Date: 18/04/2016 Received Date: 13/12/2015 Accepted Date: 18/04/2016 Online Date: 30/04/2016 Article note: Electronic supplementary material The online version of this article (doi: 10.1007/s00330-016-4375-6) contains supplementary material, which is available to authorized users.
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