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Preliminary study of diffusion kurtosis imaging in thyroid nodules and its histopathologic correlation

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00330-017-4874-0 Byline: Ruo-yang Shi (1), Qiu-ying Yao (1), Qin-yi Zhou (2), Qing Lu (1), Shi-teng Suo (1), Jun Chen (2), Wen-jie Zheng (2), Yong-ming Dai (3), Lian-m... Full description

Journal Title: European Radiology 2017, Vol.27(11), pp.4710-4720
Main Author: Shi, Ruo-yang
Other Authors: Yao, Qiu-ying , Zhou, Qin-yi , Lu, Qing , Suo, Shi-teng , Chen, Jun , Zheng, Wen-jie , Dai, Yong-ming , Wu, Lian-ming , Xu, Jian-rong
Format: Electronic Article Electronic Article
Language: English
Subjects:
DWI
DKI
ID: ISSN: 0938-7994 ; E-ISSN: 1432-1084 ; DOI: 10.1007/s00330-017-4874-0
Link: http://dx.doi.org/10.1007/s00330-017-4874-0
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recordid: springer_jour10.1007/s00330-017-4874-0
title: Preliminary study of diffusion kurtosis imaging in thyroid nodules and its histopathologic correlation
format: Article
creator:
  • Shi, Ruo-yang
  • Yao, Qiu-ying
  • Zhou, Qin-yi
  • Lu, Qing
  • Suo, Shi-teng
  • Chen, Jun
  • Zheng, Wen-jie
  • Dai, Yong-ming
  • Wu, Lian-ming
  • Xu, Jian-rong
subjects:
  • Thyroid nodule
  • Thyroid
  • DWI
  • DKI
  • VEGF
ispartof: European Radiology, 2017, Vol.27(11), pp.4710-4720
description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00330-017-4874-0 Byline: Ruo-yang Shi (1), Qiu-ying Yao (1), Qin-yi Zhou (2), Qing Lu (1), Shi-teng Suo (1), Jun Chen (2), Wen-jie Zheng (2), Yong-ming Dai (3), Lian-ming Wu (1), Jian-rong Xu (1) Keywords: Thyroid nodule; Thyroid; DWI; DKI; VEGF Abstract: Objectives To evaluate the utility of diffusion kurtosis imaging (DKI) of patients with thyroid nodules and to assess the probable correlation with histopathological factors. Methods The study included 58 consecutive patients with thyroid nodules who underwent magnetic resonance imaging (MRI) examination, including DKI and diffusion-weighted imaging (DWI). Histopathological analysis of paraffin sections included cell density and immunohistochemical analysis of Ki-67 and vascular endothelial growth factor (VEGF). Statistical analyses were performed using Student's t-test, receiver operating characteristic (ROC) curves and Spearman's correlation. Results The diffusion parameters, cell density and immunohistochemistry analysis between malignant and benign lesions showed significant differences. The largest area under the ROC curve was acquired for the D value (AUC=0.797). The highest sensitivity was shown with the use of K (threshold=0.832, sensitivity=0.917). The Ki-67 expression generally stayed low. A moderate correlation was found between ADC, D and cell density (r=-0.536, P=0.000 r=-0.570, P=0.000) and ADC, D and VEGF expression (r=-0.451, P=0.000 r=-0.522, P=0.000). Conclusion The DKI-derived parameters D and K demonstrated an advantage compared to conventional DWI for thyroid lesion diagnosis. While the histopathological study indicated that the D value correlated better with extracellular change than the ADC value, the K value probably changed relative to the intracellular structure. Key Points acents DWI and DKI parameters can identify PTC from benign thyroid nodules. acents Correlations were found between diffusion parameters and histopathological analysis. acents DKI obtains better diagnostic accuracy than conventional DWI. Author Affiliation: (1) Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Road, Shanghai, 200127, China (2) Department of Head and Neck Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (3) Magnetic Resonance Imaging Institute for Biomedical Resea
language: eng
source:
identifier: ISSN: 0938-7994 ; E-ISSN: 1432-1084 ; DOI: 10.1007/s00330-017-4874-0
fulltext: fulltext
issn:
  • 1432-1084
  • 14321084
  • 0938-7994
  • 09387994
url: Link


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titlePreliminary study of diffusion kurtosis imaging in thyroid nodules and its histopathologic correlation
creatorShi, Ruo-yang ; Yao, Qiu-ying ; Zhou, Qin-yi ; Lu, Qing ; Suo, Shi-teng ; Chen, Jun ; Zheng, Wen-jie ; Dai, Yong-ming ; Wu, Lian-ming ; Xu, Jian-rong
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descriptionTo access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00330-017-4874-0 Byline: Ruo-yang Shi (1), Qiu-ying Yao (1), Qin-yi Zhou (2), Qing Lu (1), Shi-teng Suo (1), Jun Chen (2), Wen-jie Zheng (2), Yong-ming Dai (3), Lian-ming Wu (1), Jian-rong Xu (1) Keywords: Thyroid nodule; Thyroid; DWI; DKI; VEGF Abstract: Objectives To evaluate the utility of diffusion kurtosis imaging (DKI) of patients with thyroid nodules and to assess the probable correlation with histopathological factors. Methods The study included 58 consecutive patients with thyroid nodules who underwent magnetic resonance imaging (MRI) examination, including DKI and diffusion-weighted imaging (DWI). Histopathological analysis of paraffin sections included cell density and immunohistochemical analysis of Ki-67 and vascular endothelial growth factor (VEGF). Statistical analyses were performed using Student's t-test, receiver operating characteristic (ROC) curves and Spearman's correlation. Results The diffusion parameters, cell density and immunohistochemistry analysis between malignant and benign lesions showed significant differences. The largest area under the ROC curve was acquired for the D value (AUC=0.797). The highest sensitivity was shown with the use of K (threshold=0.832, sensitivity=0.917). The Ki-67 expression generally stayed low. A moderate correlation was found between ADC, D and cell density (r=-0.536, P=0.000 r=-0.570, P=0.000) and ADC, D and VEGF expression (r=-0.451, P=0.000 r=-0.522, P=0.000). Conclusion The DKI-derived parameters D and K demonstrated an advantage compared to conventional DWI for thyroid lesion diagnosis. While the histopathological study indicated that the D value correlated better with extracellular change than the ADC value, the K value probably changed relative to the intracellular structure. Key Points acents DWI and DKI parameters can identify PTC from benign thyroid nodules. acents Correlations were found between diffusion parameters and histopathological analysis. acents DKI obtains better diagnostic accuracy than conventional DWI. Author Affiliation: (1) Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Road, Shanghai, 200127, China (2) Department of Head and Neck Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (3) Magnetic Resonance Imaging Institute for Biomedical Research, Wayne State University, Detroit, MI, USA Article History: Registration Date: 02/05/2017 Received Date: 28/11/2016 Accepted Date: 02/05/2017 Online Date: 14/06/2017 Article note: Ruo-yang Shi and Qiu-ying Yao contributed equally to this work.
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