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Impact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and plaque regression by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography (MILLION) study

The aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This s... Full description

Journal Title: Heart and Vessels 2017, Vol.32(5), pp.539-548
Main Author: Kawashiri, Masa-aki
Other Authors: Sakata, Kenji , Hayashi, Kenshi , Gamou, Tadatsugu , Kanaya, Honin , Miwa, Kenji , Ueda, Kosei , Higashikata, Toshinori , Mizuno, Sumio , Michishita, Ichiro , Namura, Masanobu , Nitta, Yutaka , Katsuda, Shoji , Okeie, Kazuyasu , Hirase, Hiroaki , Tada, Hayato , Uchiyama, Katsuharu , Konno, Tetsuo , Ino, Hidekazu , Nagase, Keisuke , Yamagishi, Masakazu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0910-8327 ; E-ISSN: 1615-2573 ; DOI: 10.1007/s00380-016-0910-2
Link: http://dx.doi.org/10.1007/s00380-016-0910-2
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recordid: springer_jour10.1007/s00380-016-0910-2
title: Impact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and plaque regression by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography (MILLION) study
format: Article
creator:
  • Kawashiri, Masa-aki
  • Sakata, Kenji
  • Hayashi, Kenshi
  • Gamou, Tadatsugu
  • Kanaya, Honin
  • Miwa, Kenji
  • Ueda, Kosei
  • Higashikata, Toshinori
  • Mizuno, Sumio
  • Michishita, Ichiro
  • Namura, Masanobu
  • Nitta, Yutaka
  • Katsuda, Shoji
  • Okeie, Kazuyasu
  • Hirase, Hiroaki
  • Tada, Hayato
  • Uchiyama, Katsuharu
  • Konno, Tetsuo
  • Ino, Hidekazu
  • Nagase, Keisuke
  • Yamagishi, Masakazu
subjects:
  • Coronary plaque volume
  • Amlodipine
  • Atorvastatin
  • Intravascular ultrasound
ispartof: Heart and Vessels, 2017, Vol.32(5), pp.539-548
description: The aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0 ± 9.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18–24 months follow-up. Patients were randomly assigned to standard or aggressive strategies targeting LDL-C and a BP of 100 mg/dL and 140/90 mmHg vs. 70 mg/dL and 120/70 mmHg, respectively. The primary endpoint was the percent change in coronary plaque volume. Both standard and aggressive strategies succeeded to achieve target levels of LDL-C and BP; 74.9 ± 14.7 vs. 63.7 ± 11.9 mg/dL (NS) and 124.1 ± 9.4/75.8 ± 7.7 vs. 113.6 ± 9.6/65.8 ± 9.4 mmHg (systolic BP; NS, diastolic BP; p  
language: eng
source:
identifier: ISSN: 0910-8327 ; E-ISSN: 1615-2573 ; DOI: 10.1007/s00380-016-0910-2
fulltext: fulltext
issn:
  • 1615-2573
  • 16152573
  • 0910-8327
  • 09108327
url: Link


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titleImpact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and plaque regression by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography (MILLION) study
creatorKawashiri, Masa-aki ; Sakata, Kenji ; Hayashi, Kenshi ; Gamou, Tadatsugu ; Kanaya, Honin ; Miwa, Kenji ; Ueda, Kosei ; Higashikata, Toshinori ; Mizuno, Sumio ; Michishita, Ichiro ; Namura, Masanobu ; Nitta, Yutaka ; Katsuda, Shoji ; Okeie, Kazuyasu ; Hirase, Hiroaki ; Tada, Hayato ; Uchiyama, Katsuharu ; Konno, Tetsuo ; Ino, Hidekazu ; Nagase, Keisuke ; Yamagishi, Masakazu
ispartofHeart and Vessels, 2017, Vol.32(5), pp.539-548
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subjectCoronary plaque volume ; Amlodipine ; Atorvastatin ; Intravascular ultrasound
descriptionThe aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0 ± 9.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18–24 months follow-up. Patients were randomly assigned to standard or aggressive strategies targeting LDL-C and a BP of 100 mg/dL and 140/90 mmHg vs. 70 mg/dL and 120/70 mmHg, respectively. The primary endpoint was the percent change in coronary plaque volume. Both standard and aggressive strategies succeeded to achieve target levels of LDL-C and BP; 74.9 ± 14.7 vs. 63.7 ± 11.9 mg/dL (NS) and 124.1 ± 9.4/75.8 ± 7.7 vs. 113.6 ± 9.6/65.8 ± 9.4 mmHg (systolic BP; NS, diastolic BP; p  < 0.05), respectively. Both groups showed a significant reduction in the coronary plaque volume of −9.4 ± 10.7% and −8.7 ± 8.6% (NS) in standard and aggressive therapies, respectively. Both standard and aggressive intervention significantly regressed coronary plaque volume by the same degree, suggesting the importance of simultaneous reductions of LDL-C and BP for prevention of CAD.
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titleImpact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and plaque regression by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography (MILLION) study
descriptionThe aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0 ± 9.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18–24 months follow-up. Patients were randomly assigned to standard or aggressive strategies targeting LDL-C and a BP of 100 mg/dL and 140/90 mmHg vs. 70 mg/dL and 120/70 mmHg, respectively. The primary endpoint was the percent change in coronary plaque volume. Both standard and aggressive strategies succeeded to achieve target levels of LDL-C and BP; 74.9 ± 14.7 vs. 63.7 ± 11.9 mg/dL (NS) and 124.1 ± 9.4/75.8 ± 7.7 vs. 113.6 ± 9.6/65.8 ± 9.4 mmHg (systolic BP; NS, diastolic BP; p  < 0.05), respectively. Both groups showed a significant reduction in the coronary plaque volume of −9.4 ± 10.7% and −8.7 ± 8.6% (NS) in standard and aggressive therapies, respectively. Both standard and aggressive intervention significantly regressed coronary plaque volume by the same degree, suggesting the importance of simultaneous reductions of LDL-C and BP for prevention of CAD.
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titleImpact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and plaque regression by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography (MILLION) study
authorKawashiri, Masa-aki ; Sakata, Kenji ; Hayashi, Kenshi ; Gamou, Tadatsugu ; Kanaya, Honin ; Miwa, Kenji ; Ueda, Kosei ; Higashikata, Toshinori ; Mizuno, Sumio ; Michishita, Ichiro ; Namura, Masanobu ; Nitta, Yutaka ; Katsuda, Shoji ; Okeie, Kazuyasu ; Hirase, Hiroaki ; Tada, Hayato ; Uchiyama, Katsuharu ; Konno, Tetsuo ; Ino, Hidekazu ; Nagase, Keisuke ; Yamagishi, Masakazu
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atitleImpact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and plaque regression by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography (MILLION) study
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abstractThe aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0 ± 9.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18–24 months follow-up. Patients were randomly assigned to standard or aggressive strategies targeting LDL-C and a BP of 100 mg/dL and 140/90 mmHg vs. 70 mg/dL and 120/70 mmHg, respectively. The primary endpoint was the percent change in coronary plaque volume. Both standard and aggressive strategies succeeded to achieve target levels of LDL-C and BP; 74.9 ± 14.7 vs. 63.7 ± 11.9 mg/dL (NS) and 124.1 ± 9.4/75.8 ± 7.7 vs. 113.6 ± 9.6/65.8 ± 9.4 mmHg (systolic BP; NS, diastolic BP; p  < 0.05), respectively. Both groups showed a significant reduction in the coronary plaque volume of −9.4 ± 10.7% and −8.7 ± 8.6% (NS) in standard and aggressive therapies, respectively. Both standard and aggressive intervention significantly regressed coronary plaque volume by the same degree, suggesting the importance of simultaneous reductions of LDL-C and BP for prevention of CAD.
copTokyo
pubSpringer Japan
doi10.1007/s00380-016-0910-2
pages539-548
date2017-05-01