schliessen

Filtern

 

Bibliotheken

Serum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet

Byline: Veronica Escurriol (1,2), Montserrat Cofan (1,2), Merce Serra (1,2), Monica Bullo (2,3), Josep Basora (2,3), Jordi Salas-Salvado (2,3), Dolores Corella (2,4), Itziar Zazpe (5), Miguel A. Martinez-Gonzalez (5), Valentina Ruiz-Gutierrez (6), Ramon Estruch (2,7), Emilio Ros (1,2) Keywords: Phyt... Full description

Journal Title: European Journal of Nutrition 2009, Vol.48(6), pp.373-382
Main Author: Escurriol, Verónica
Other Authors: Cofán, Montserrat , Serra, Mercè , Bulló, Mónica , Basora, Josep , Salas-Salvadó, Jordi , Corella, Dolores , Zazpe, Itziar , Martínez-González, Miguel , Ruiz-Gutiérrez, Valentina , Estruch, Ramón , Ros, Emilio
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1436-6207 ; E-ISSN: 1436-6215 ; DOI: 10.1007/s00394-009-0024-z
Link: http://dx.doi.org/10.1007/s00394-009-0024-z
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: springer_jour10.1007/s00394-009-0024-z
title: Serum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet
format: Article
creator:
  • Escurriol, Verónica
  • Cofán, Montserrat
  • Serra, Mercè
  • Bulló, Mónica
  • Basora, Josep
  • Salas-Salvadó, Jordi
  • Corella, Dolores
  • Zazpe, Itziar
  • Martínez-González, Miguel
  • Ruiz-Gutiérrez, Valentina
  • Estruch, Ramón
  • Ros, Emilio
subjects:
  • Phytosterols
  • Mediterranean diet
  • Nuts
  • Olive oil
  • Cholesterol
ispartof: European Journal of Nutrition, 2009, Vol.48(6), pp.373-382
description: Byline: Veronica Escurriol (1,2), Montserrat Cofan (1,2), Merce Serra (1,2), Monica Bullo (2,3), Josep Basora (2,3), Jordi Salas-Salvado (2,3), Dolores Corella (2,4), Itziar Zazpe (5), Miguel A. Martinez-Gonzalez (5), Valentina Ruiz-Gutierrez (6), Ramon Estruch (2,7), Emilio Ros (1,2) Keywords: Phytosterols; Mediterranean diet; Nuts; Olive oil; Cholesterol Abstract: Background Phytosterols in natural foods are thought to inhibit cholesterol absorption. The Mediterranean diet is rich in phytosterol-containing plant foods. Aim of the study To assess whether increasing phytosterol intake from natural foods was associated with a cholesterol-lowering effect in a substudy of a randomized trial of nutritional intervention with Mediterranean diets for primary cardiovascular prevention (PREDIMED study). Methods One hundred and six high cardiovascular risk subjects assigned to two Mediterranean diets supplemented with virgin olive oil (VOO) or nuts, which are phytosterol-rich foods, or advice on a low-fat diet. Outcomes were 1-year changes in nutrient intake and serum levels of lipids and non-cholesterol sterols. Results Average phytosterol intake increased by 76, 158 and 15 mg/day in participants assigned VOO, nuts and low-fat diets, respectively. Compared to participants in the low-fat diet group, changes in outcome variables were observed only in those in the Mediterranean diet with nuts group, with increases in intake of fibre, polyunsaturated fatty acids and phytosterols (P < 0.020, all) and significant (P < 0.05) reductions of LDL-cholesterol (0.27 mmol/l or 8.3%) and the LDL/HDL-cholesterol ratio (0.29 mmol/l or 11.5%). Variations in saturated fat, cholesterol or fibre intake were unrelated to LDL-cholesterol changes. In the whole group, changes in serum sitosterol-to-cholesterol, which reflect those of dietary phytosterol intake and absorption, correlated inversely to LDL-cholesterol changes (r = -0.256 P = 0.008). In multivariate analyses, baseline LDL-cholesterol, increases in serum sitosterol ratios and statin use were independently associated with LDL-cholesterol reductions. Conclusions Small amounts of phytosterols in natural foods appear to be bioactive in cholesterol lowering. Author Affiliation: (1) Lipid Clinic, Endocrinology and Nutrition Service, Institut d'Investigacions Biomediques Ausgust Pi Sunyer (IDIBAPS), Hospital Clinic, C. Villarroel 170, 08036, Barcelona, Spain (2) Ciber Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de
language: eng
source:
identifier: ISSN: 1436-6207 ; E-ISSN: 1436-6215 ; DOI: 10.1007/s00394-009-0024-z
fulltext: fulltext
issn:
  • 1436-6215
  • 14366215
  • 1436-6207
  • 14366207
url: Link


@attributes
ID130524769
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1007/s00394-009-0024-z
sourceidspringer_jour
recordidTN_springer_jour10.1007/s00394-009-0024-z
sourcesystemOther
pqid734036978
galeid229619783
display
typearticle
titleSerum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet
creatorEscurriol, Verónica ; Cofán, Montserrat ; Serra, Mercè ; Bulló, Mónica ; Basora, Josep ; Salas-Salvadó, Jordi ; Corella, Dolores ; Zazpe, Itziar ; Martínez-González, Miguel ; Ruiz-Gutiérrez, Valentina ; Estruch, Ramón ; Ros, Emilio
ispartofEuropean Journal of Nutrition, 2009, Vol.48(6), pp.373-382
identifier
subjectPhytosterols ; Mediterranean diet ; Nuts ; Olive oil ; Cholesterol
languageeng
source
descriptionByline: Veronica Escurriol (1,2), Montserrat Cofan (1,2), Merce Serra (1,2), Monica Bullo (2,3), Josep Basora (2,3), Jordi Salas-Salvado (2,3), Dolores Corella (2,4), Itziar Zazpe (5), Miguel A. Martinez-Gonzalez (5), Valentina Ruiz-Gutierrez (6), Ramon Estruch (2,7), Emilio Ros (1,2) Keywords: Phytosterols; Mediterranean diet; Nuts; Olive oil; Cholesterol Abstract: Background Phytosterols in natural foods are thought to inhibit cholesterol absorption. The Mediterranean diet is rich in phytosterol-containing plant foods. Aim of the study To assess whether increasing phytosterol intake from natural foods was associated with a cholesterol-lowering effect in a substudy of a randomized trial of nutritional intervention with Mediterranean diets for primary cardiovascular prevention (PREDIMED study). Methods One hundred and six high cardiovascular risk subjects assigned to two Mediterranean diets supplemented with virgin olive oil (VOO) or nuts, which are phytosterol-rich foods, or advice on a low-fat diet. Outcomes were 1-year changes in nutrient intake and serum levels of lipids and non-cholesterol sterols. Results Average phytosterol intake increased by 76, 158 and 15 mg/day in participants assigned VOO, nuts and low-fat diets, respectively. Compared to participants in the low-fat diet group, changes in outcome variables were observed only in those in the Mediterranean diet with nuts group, with increases in intake of fibre, polyunsaturated fatty acids and phytosterols (P < 0.020, all) and significant (P < 0.05) reductions of LDL-cholesterol (0.27 mmol/l or 8.3%) and the LDL/HDL-cholesterol ratio (0.29 mmol/l or 11.5%). Variations in saturated fat, cholesterol or fibre intake were unrelated to LDL-cholesterol changes. In the whole group, changes in serum sitosterol-to-cholesterol, which reflect those of dietary phytosterol intake and absorption, correlated inversely to LDL-cholesterol changes (r = -0.256 P = 0.008). In multivariate analyses, baseline LDL-cholesterol, increases in serum sitosterol ratios and statin use were independently associated with LDL-cholesterol reductions. Conclusions Small amounts of phytosterols in natural foods appear to be bioactive in cholesterol lowering. Author Affiliation: (1) Lipid Clinic, Endocrinology and Nutrition Service, Institut d'Investigacions Biomediques Ausgust Pi Sunyer (IDIBAPS), Hospital Clinic, C. Villarroel 170, 08036, Barcelona, Spain (2) Ciber Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain (3) Human Nutrition Department, Hospital de Sant Joan, University Rovira i Virgili, Reus, Spain (4) Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain (5) Department of Preventive Medicine and Public Health, Clinica Universitaria, University of Navarra, Pamplona, Spain (6) Instituto de la Grasa, Centro Superior de Investigaciones Cientificas (CSIC), Seville, Spain (7) Department of Internal Medicine, IDIBAPS, Hospital Clinic, Barcelona, Spain Article History: Registration Date: 06/04/2009 Received Date: 27/01/2009 Accepted Date: 06/04/2009 Online Date: 03/05/2009
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://dx.doi.org/10.1007/s00394-009-0024-z$$EView_full_text_in_Springer_(Subscribers_only)
search
creatorcontrib
0Escurriol, Verónica, A.
1Cofán, Montserrat, A.
2Serra, Mercè, A.
3Bulló, Mónica, A.
4Basora, Josep, A.
5Salas-Salvadó, Jordi, A.
6Corella, Dolores, A.
7Zazpe, Itziar, A.
8Martínez-González, Miguel, A.
9Ruiz-Gutiérrez, Valentina, A.
10Estruch, Ramón, A.
11Ros, Emilio, A.
titleSerum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet
subject
0Phytosterols
1Mediterranean diet
2Nuts
3Olive oil
4Cholesterol
general
010.1007/s00394-009-0024-z
1English
2Springer Science & Business Media B.V.
3SpringerLink
sourceidspringer_jour
recordidspringer_jour10.1007/s00394-009-0024-z
issn
01436-6215
114366215
21436-6207
314366207
rsrctypearticle
creationdate2009
addtitle
0European Journal of Nutrition
1Eur J Nutr
searchscopespringer_journals_complete
scopespringer_journals_complete
lsr30VSR-Enriched:[pqid, pages, galeid, description]
sort
titleSerum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet
authorEscurriol, Verónica ; Cofán, Montserrat ; Serra, Mercè ; Bulló, Mónica ; Basora, Josep ; Salas-Salvadó, Jordi ; Corella, Dolores ; Zazpe, Itziar ; Martínez-González, Miguel ; Ruiz-Gutiérrez, Valentina ; Estruch, Ramón ; Ros, Emilio
creationdate20090900
facets
frbrgroupid8749418901778072252
frbrtype5
languageeng
creationdate2009
topic
0Phytosterols
1Mediterranean Diet
2Nuts
3Olive Oil
4Cholesterol
collectionSpringerLink
prefilterarticles
rsrctypearticles
creatorcontrib
0Escurriol, Verónica
1Cofán, Montserrat
2Serra, Mercè
3Bulló, Mónica
4Basora, Josep
5Salas-Salvadó, Jordi
6Corella, Dolores
7Zazpe, Itziar
8Martínez-González, Miguel
9Ruiz-Gutiérrez, Valentina
10Estruch, Ramón
11Ros, Emilio
jtitleEuropean Journal Of Nutrition
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Escurriol
1Cofán
2Serra
3Bulló
4Basora
5Salas-Salvadó
6Corella
7Zazpe
8Martínez-González
9Ruiz-Gutiérrez
10Estruch
11Ros
aufirst
0Verónica
1Montserrat
2Mercè
3Mónica
4Josep
5Jordi
6Dolores
7Itziar
8Miguel
9A.
10Valentina
11Ramón
12Emilio
au
0Escurriol, Verónica
1Cofán, Montserrat
2Serra, Mercè
3Bulló, Mónica
4Basora, Josep
5Salas-Salvadó, Jordi
6Corella, Dolores
7Zazpe, Itziar
8Martínez-González, Miguel
9Ruiz-Gutiérrez, Valentina
10Estruch, Ramón
11Ros, Emilio
atitleSerum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet
jtitleEuropean Journal of Nutrition
stitleEur J Nutr
risdate200909
volume48
issue6
spage373
epage382
issn1436-6207
eissn1436-6215
genrearticle
ristypeJOUR
copHeidelberg
pubD. Steinkopff-Verlag
doi10.1007/s00394-009-0024-z
pages373-37382
date2009-09