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Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?

Byline: Giselle A. P. Pignotti (1,2), Patricia S. Genaro (1,2), Marcelo M. Pinheiro (2), Vera L. Szejnfeld (2), Ligia A. Martini (1) Keywords: Dietary intakes; Serum 25-hydroxyvitamin D; Vitamin D supplement; Postmenopausal; Osteoporosis Abstract: Background Calcium and vitamin D are essential nutri... Full description

Journal Title: European Journal of Nutrition 2010, Vol.49(5), pp.277-283
Main Author: Pignotti, Giselle
Other Authors: Genaro, Patrícia , Pinheiro, Marcelo , Szejnfeld, Vera , Martini, Lígia
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1436-6207 ; E-ISSN: 1436-6215 ; DOI: 10.1007/s00394-009-0084-0
Link: http://dx.doi.org/10.1007/s00394-009-0084-0
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recordid: springer_jour10.1007/s00394-009-0084-0
title: Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?
format: Article
creator:
  • Pignotti, Giselle
  • Genaro, Patrícia
  • Pinheiro, Marcelo
  • Szejnfeld, Vera
  • Martini, Lígia
subjects:
  • Dietary intakes
  • Serum 25-hydroxyvitamin D
  • Vitamin D supplement
  • Postmenopausal
  • Osteoporosis
ispartof: European Journal of Nutrition, 2010, Vol.49(5), pp.277-283
description: Byline: Giselle A. P. Pignotti (1,2), Patricia S. Genaro (1,2), Marcelo M. Pinheiro (2), Vera L. Szejnfeld (2), Ligia A. Martini (1) Keywords: Dietary intakes; Serum 25-hydroxyvitamin D; Vitamin D supplement; Postmenopausal; Osteoporosis Abstract: Background Calcium and vitamin D are essential nutrients for bone metabolism Vitamin D can either be obtained from dietary sources or cutaneous synthesis. The study was conducted in subtropic weather therefore, some might believe that the levels of solar radiation would be sufficient in this area. Aim of the study To evaluate calcium and vitamin D supplementation in postmenopausal women with osteoporosis living in a sunny country. Methods A 3-month controlled clinical trial with 64 postmenopausal women with osteoporosis, mean age 62 +- 8 years. They were randomly assigned to either the supplement group, who received 1,200 mg of calcium carbonate and 400 IU (10 ug) of vitamin D.sub.3, or the control group. Dietary intake assessment was performed, bone mineral density and body composition were measured, and biochemical markers of bone metabolism were analyzed. Results Considering all participants at baseline, serum vitamin D was under 75 nmol/l in 91.4% of the participants. The concentration of serum 25(OH)D increased significantly (p = 0.023) after 3 months of supplementation from 46.67 +- 13.97 to 59.47 +- 17.50 nmol/l. However, the dose given was limited in effect, and 86.2% of the supplement group did not reach optimal levels of 25(OH)D. Parathyroid hormone was elevated in 22.4% of the study group. After the intervention period, mean parathyroid hormone tended to decrease in the supplement group (p = 0.063). Conclusion The dose given (400 IU/day) was not enough to achieve 25(OH)D concentration, considered optimal for bone health. Author Affiliation: (1) Nutrition Department, School of Public Health, University of Sao Paulo, Av Dr Arnaldo, 715, Sao Paulo, SP, CEP 01246-904, Brazil (2) Rheumatology Department, Medical School, Federal University of Sao Paulo, Sao Paulo, Brazil Article History: Registration Date: 10/11/2009 Received Date: 20/07/2009 Accepted Date: 10/11/2009 Online Date: 28/11/2009
language: eng
source:
identifier: ISSN: 1436-6207 ; E-ISSN: 1436-6215 ; DOI: 10.1007/s00394-009-0084-0
fulltext: fulltext
issn:
  • 1436-6215
  • 14366215
  • 1436-6207
  • 14366207
url: Link


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titleIs a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?
creatorPignotti, Giselle ; Genaro, Patrícia ; Pinheiro, Marcelo ; Szejnfeld, Vera ; Martini, Lígia
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descriptionByline: Giselle A. P. Pignotti (1,2), Patricia S. Genaro (1,2), Marcelo M. Pinheiro (2), Vera L. Szejnfeld (2), Ligia A. Martini (1) Keywords: Dietary intakes; Serum 25-hydroxyvitamin D; Vitamin D supplement; Postmenopausal; Osteoporosis Abstract: Background Calcium and vitamin D are essential nutrients for bone metabolism Vitamin D can either be obtained from dietary sources or cutaneous synthesis. The study was conducted in subtropic weather therefore, some might believe that the levels of solar radiation would be sufficient in this area. Aim of the study To evaluate calcium and vitamin D supplementation in postmenopausal women with osteoporosis living in a sunny country. Methods A 3-month controlled clinical trial with 64 postmenopausal women with osteoporosis, mean age 62 +- 8 years. They were randomly assigned to either the supplement group, who received 1,200 mg of calcium carbonate and 400 IU (10 ug) of vitamin D.sub.3, or the control group. Dietary intake assessment was performed, bone mineral density and body composition were measured, and biochemical markers of bone metabolism were analyzed. Results Considering all participants at baseline, serum vitamin D was under 75 nmol/l in 91.4% of the participants. The concentration of serum 25(OH)D increased significantly (p = 0.023) after 3 months of supplementation from 46.67 +- 13.97 to 59.47 +- 17.50 nmol/l. However, the dose given was limited in effect, and 86.2% of the supplement group did not reach optimal levels of 25(OH)D. Parathyroid hormone was elevated in 22.4% of the study group. After the intervention period, mean parathyroid hormone tended to decrease in the supplement group (p = 0.063). Conclusion The dose given (400 IU/day) was not enough to achieve 25(OH)D concentration, considered optimal for bone health. Author Affiliation: (1) Nutrition Department, School of Public Health, University of Sao Paulo, Av Dr Arnaldo, 715, Sao Paulo, SP, CEP 01246-904, Brazil (2) Rheumatology Department, Medical School, Federal University of Sao Paulo, Sao Paulo, Brazil Article History: Registration Date: 10/11/2009 Received Date: 20/07/2009 Accepted Date: 10/11/2009 Online Date: 28/11/2009
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