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Differential effects of a K + channel agonist and Ca 2+ antagonists on myosin light chain phosphorylation in relaxation of endothelin-1-contracted tracheal smooth muscle

 Smooth muscle contraction and relaxation are generally considered to be associated with phosphorylation and dephosphorylation of the 20-kDa regulatory myosin light chain (LC 20 ). Thus, contractions of lamb tracheal smooth muscle induced by Bay K 8644 and relaxed by calcium channel blockers (verapa... Full description

Journal Title: Pflügers Archiv 1997, Vol.433(4), pp.472-477
Main Author: Katoch, Surender S.
Other Authors: Rüegg, J. C. , Pfitzer, Gabriele
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0031-6768 ; E-ISSN: 1432-2013 ; DOI: 10.1007/s004240050302
Link: http://dx.doi.org/10.1007/s004240050302
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recordid: springer_jour10.1007/s004240050302
title: Differential effects of a K + channel agonist and Ca 2+ antagonists on myosin light chain phosphorylation in relaxation of endothelin-1-contracted tracheal smooth muscle
format: Article
creator:
  • Katoch, Surender S.
  • Rüegg, J. C.
  • Pfitzer, Gabriele
subjects:
  • Key words Smooth muscle
  • Myosin light chain phosphorylation
  • K channel agonists
  • Ca2+ channel blockers
  • Endothelin-1
ispartof: Pflügers Archiv, 1997, Vol.433(4), pp.472-477
description:  Smooth muscle contraction and relaxation are generally considered to be associated with phosphorylation and dephosphorylation of the 20-kDa regulatory myosin light chain (LC 20 ). Thus, contractions of lamb tracheal smooth muscle induced by Bay K 8644 and relaxed by calcium channel blockers (verapamil, D-600 and nitrendipine) are accompanied by an increase and decrease, respectively, of LC 20 phosphorylation. Similarly, endothelin-1 (ET-1) induces a sustained contraction, which is coupled with elevated LC 20 phosphorylation and reversed by LC 20 dephosphorylation after application of a potassium channel agonist (EMD 52692). In contrast, calcium channel blockers relax ET-1-induced contraction without any dephosphorylation of myosin light chains (MLC), suggesting that MLC phosphatase is inhibited in this case. Obviously, MLC dephosphorylation is not a prerequisite for smooth muscle relaxation. The variable relationship between MLC phosphorylation and force during relaxation suggests that there are mechanisms other than MLC phosphorylation that are important for regulation of contraction and relaxation in smooth muscle.
language: eng
source:
identifier: ISSN: 0031-6768 ; E-ISSN: 1432-2013 ; DOI: 10.1007/s004240050302
fulltext: fulltext
issn:
  • 1432-2013
  • 14322013
  • 0031-6768
  • 00316768
url: Link


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titleDifferential effects of a K + channel agonist and Ca 2+ antagonists on myosin light chain phosphorylation in relaxation of endothelin-1-contracted tracheal smooth muscle
creatorKatoch, Surender S. ; Rüegg, J. C. ; Pfitzer, Gabriele
ispartofPflügers Archiv, 1997, Vol.433(4), pp.472-477
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subjectKey words Smooth muscle ; Myosin light chain phosphorylation ; K channel agonists ; Ca2+ channel blockers ; Endothelin-1
description Smooth muscle contraction and relaxation are generally considered to be associated with phosphorylation and dephosphorylation of the 20-kDa regulatory myosin light chain (LC 20 ). Thus, contractions of lamb tracheal smooth muscle induced by Bay K 8644 and relaxed by calcium channel blockers (verapamil, D-600 and nitrendipine) are accompanied by an increase and decrease, respectively, of LC 20 phosphorylation. Similarly, endothelin-1 (ET-1) induces a sustained contraction, which is coupled with elevated LC 20 phosphorylation and reversed by LC 20 dephosphorylation after application of a potassium channel agonist (EMD 52692). In contrast, calcium channel blockers relax ET-1-induced contraction without any dephosphorylation of myosin light chains (MLC), suggesting that MLC phosphatase is inhibited in this case. Obviously, MLC dephosphorylation is not a prerequisite for smooth muscle relaxation. The variable relationship between MLC phosphorylation and force during relaxation suggests that there are mechanisms other than MLC phosphorylation that are important for regulation of contraction and relaxation in smooth muscle.
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titleDifferential effects of a K + channel agonist and Ca 2+ antagonists on myosin light chain phosphorylation in relaxation of endothelin-1-contracted tracheal smooth muscle
description Smooth muscle contraction and relaxation are generally considered to be associated with phosphorylation and dephosphorylation of the 20-kDa regulatory myosin light chain (LC 20 ). Thus, contractions of lamb tracheal smooth muscle induced by Bay K 8644 and relaxed by calcium channel blockers (verapamil, D-600 and nitrendipine) are accompanied by an increase and decrease, respectively, of LC 20 phosphorylation. Similarly, endothelin-1 (ET-1) induces a sustained contraction, which is coupled with elevated LC 20 phosphorylation and reversed by LC 20 dephosphorylation after application of a potassium channel agonist (EMD 52692). In contrast, calcium channel blockers relax ET-1-induced contraction without any dephosphorylation of myosin light chains (MLC), suggesting that MLC phosphatase is inhibited in this case. Obviously, MLC dephosphorylation is not a prerequisite for smooth muscle relaxation. The variable relationship between MLC phosphorylation and force during relaxation suggests that there are mechanisms other than MLC phosphorylation that are important for regulation of contraction and relaxation in smooth muscle.
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titleDifferential effects of a K + channel agonist and Ca 2+ antagonists on myosin light chain phosphorylation in relaxation of endothelin-1-contracted tracheal smooth muscle
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abstract Smooth muscle contraction and relaxation are generally considered to be associated with phosphorylation and dephosphorylation of the 20-kDa regulatory myosin light chain (LC 20 ). Thus, contractions of lamb tracheal smooth muscle induced by Bay K 8644 and relaxed by calcium channel blockers (verapamil, D-600 and nitrendipine) are accompanied by an increase and decrease, respectively, of LC 20 phosphorylation. Similarly, endothelin-1 (ET-1) induces a sustained contraction, which is coupled with elevated LC 20 phosphorylation and reversed by LC 20 dephosphorylation after application of a potassium channel agonist (EMD 52692). In contrast, calcium channel blockers relax ET-1-induced contraction without any dephosphorylation of myosin light chains (MLC), suggesting that MLC phosphatase is inhibited in this case. Obviously, MLC dephosphorylation is not a prerequisite for smooth muscle relaxation. The variable relationship between MLC phosphorylation and force during relaxation suggests that there are mechanisms other than MLC phosphorylation that are important for regulation of contraction and relaxation in smooth muscle.
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doi10.1007/s004240050302
pages472-477
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