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An MRI atlas of the mouse basal ganglia

The basal ganglia are a group of subpallial nuclei that play an important role in motor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and... Full description

Journal Title: Brain Structure and Function 2014, Vol.219(4), pp.1343-1353
Main Author: Ullmann, Jeremy
Other Authors: Watson, Charles , Janke, Andrew , Kurniawan, Nyoman , Paxinos, George , Reutens, David
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1863-2653 ; E-ISSN: 1863-2661 ; DOI: 10.1007/s00429-013-0572-0
Link: http://dx.doi.org/10.1007/s00429-013-0572-0
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recordid: springer_jour10.1007/s00429-013-0572-0
title: An MRI atlas of the mouse basal ganglia
format: Article
creator:
  • Ullmann, Jeremy
  • Watson, Charles
  • Janke, Andrew
  • Kurniawan, Nyoman
  • Paxinos, George
  • Reutens, David
subjects:
  • Basal ganglia
  • Pallidum
  • Striatum
  • Mouse brain
  • Atlas
  • Magnetic resonance imaging
ispartof: Brain Structure and Function, 2014, Vol.219(4), pp.1343-1353
description: The basal ganglia are a group of subpallial nuclei that play an important role in motor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and movement disorders. While high-resolution magnetic resonance imaging has been used to characterize changes in brain structure in mouse models of these disorders, no systematic method for segmentation of the C57BL/6 J mouse basal ganglia exists. In this study we have used high-resolution MR images of ex vivo C57BL/6 J mouse brain to create a detailed protocol for segmenting the basal ganglia. We created a three-dimensional minimum deformation atlas, which includes the segmentation of 35 striatal, pallidal, and basal ganglia-related structures. In addition, we provide mean volumes, mean T 2 contrast intensities and mean FA and ADC values for each structure. This MR atlas is available for download, and enables researchers to perform automated segmentation in genetic models of basal ganglia disorders.
language: eng
source:
identifier: ISSN: 1863-2653 ; E-ISSN: 1863-2661 ; DOI: 10.1007/s00429-013-0572-0
fulltext: fulltext
issn:
  • 1863-2661
  • 18632661
  • 1863-2653
  • 18632653
url: Link


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titleAn MRI atlas of the mouse basal ganglia
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subjectBasal ganglia ; Pallidum ; Striatum ; Mouse brain ; Atlas ; Magnetic resonance imaging
descriptionThe basal ganglia are a group of subpallial nuclei that play an important role in motor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and movement disorders. While high-resolution magnetic resonance imaging has been used to characterize changes in brain structure in mouse models of these disorders, no systematic method for segmentation of the C57BL/6 J mouse basal ganglia exists. In this study we have used high-resolution MR images of ex vivo C57BL/6 J mouse brain to create a detailed protocol for segmenting the basal ganglia. We created a three-dimensional minimum deformation atlas, which includes the segmentation of 35 striatal, pallidal, and basal ganglia-related structures. In addition, we provide mean volumes, mean T 2 contrast intensities and mean FA and ADC values for each structure. This MR atlas is available for download, and enables researchers to perform automated segmentation in genetic models of basal ganglia disorders.
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titleAn MRI atlas of the mouse basal ganglia
descriptionThe basal ganglia are a group of subpallial nuclei that play an important role in motor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and movement disorders. While high-resolution magnetic resonance imaging has been used to characterize changes in brain structure in mouse models of these disorders, no systematic method for segmentation of the C57BL/6 J mouse basal ganglia exists. In this study we have used high-resolution MR images of ex vivo C57BL/6 J mouse brain to create a detailed protocol for segmenting the basal ganglia. We created a three-dimensional minimum deformation atlas, which includes the segmentation of 35 striatal, pallidal, and basal ganglia-related structures. In addition, we provide mean volumes, mean T 2 contrast intensities and mean FA and ADC values for each structure. This MR atlas is available for download, and enables researchers to perform automated segmentation in genetic models of basal ganglia disorders.
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abstractThe basal ganglia are a group of subpallial nuclei that play an important role in motor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and movement disorders. While high-resolution magnetic resonance imaging has been used to characterize changes in brain structure in mouse models of these disorders, no systematic method for segmentation of the C57BL/6 J mouse basal ganglia exists. In this study we have used high-resolution MR images of ex vivo C57BL/6 J mouse brain to create a detailed protocol for segmenting the basal ganglia. We created a three-dimensional minimum deformation atlas, which includes the segmentation of 35 striatal, pallidal, and basal ganglia-related structures. In addition, we provide mean volumes, mean T 2 contrast intensities and mean FA and ADC values for each structure. This MR atlas is available for download, and enables researchers to perform automated segmentation in genetic models of basal ganglia disorders.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
doi10.1007/s00429-013-0572-0
pages1343-53
date2014-07