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Evidence of the cross talk between Wnt and Notch signaling pathways in non-small-cell lung cancer (NSCLC): Notch3-siRNA weakens the effect of LiCl on the cell cycle of NSCLC cell lines

Byline: Chunyan Li (1), Ying Zhang (1), Yao Lu (1), Zeshi Cui (1), Miao Yu (1), Siyang Zhang (1), Xiaoxia Xue (1) Keywords: Wnt signaling; Notch signaling; Lung cancer; Cell cycle Abstract: Background Aberrant activations of Wnt and Notch signaling pathways are individually reported to be associated... Full description

Journal Title: Journal of Cancer Research and Clinical Oncology 2011, Vol.137(5), pp.771-778
Main Author: Li, Chunyan
Other Authors: Zhang, Ying , Lu, Yao , Cui, Zeshi , Yu, Miao , Zhang, Siyang , Xue, Xiaoxia
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0171-5216 ; E-ISSN: 1432-1335 ; DOI: 10.1007/s00432-010-0934-4
Link: http://dx.doi.org/10.1007/s00432-010-0934-4
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recordid: springer_jour10.1007/s00432-010-0934-4
title: Evidence of the cross talk between Wnt and Notch signaling pathways in non-small-cell lung cancer (NSCLC): Notch3-siRNA weakens the effect of LiCl on the cell cycle of NSCLC cell lines
format: Article
creator:
  • Li, Chunyan
  • Zhang, Ying
  • Lu, Yao
  • Cui, Zeshi
  • Yu, Miao
  • Zhang, Siyang
  • Xue, Xiaoxia
subjects:
  • Wnt signaling
  • Notch signaling
  • Lung cancer
  • Cell cycle
ispartof: Journal of Cancer Research and Clinical Oncology, 2011, Vol.137(5), pp.771-778
description: Byline: Chunyan Li (1), Ying Zhang (1), Yao Lu (1), Zeshi Cui (1), Miao Yu (1), Siyang Zhang (1), Xiaoxia Xue (1) Keywords: Wnt signaling; Notch signaling; Lung cancer; Cell cycle Abstract: Background Aberrant activations of Wnt and Notch signaling pathways are individually reported to be associated with the pathogenesis of non-small-cell lung cancer (NSCLC). However, the data about the cross talk between the two signaling pathways are still limited. To elucidate potential Wnt/Notch cross talk within NSCLC, we examined the impact of Notch3 activity on LiCl-induced cell cycle changes. Methods The lung cancer cell lines were treated with LiCl, a Wnt activator, in the absence or presence of Notch3-siRNA. Cell cycles and the expression of the regulators of cell cycle, c-MYC, p21 and Skp2 (S phase kinase-associated protein 2) were measured after treatment. Results The treatment with LiCl increased the percent of cells at S phase and G phase and the expression of c-MYC and Skp2 and decreased the expression of p21. Moreover, the expression of Notch3 and its down-stream genes, HES-1 and HEYL, was up-regulated by LiCl. Notch3-siRNA weakened the effect of LiCl on the cell cycle and resulted in attenuation of the LiCl-induced increment of c-MYC and Skp2 and the LiCl-induced decrement of p21. Conclusions These data suggest that Notch3 activation cooperatively takes part in the LiCl-induced cell cycle changes, at least partially, associated with c-MYC, Skp2 and p21. Author Affiliation: (1) Center of the Laboratory Technology and Experimental Medicine, China Medical University, 110001, Shenyang, People's Republic of China Article History: Registration Date: 21/06/2010 Received Date: 18/12/2009 Accepted Date: 21/06/2010 Online Date: 08/07/2010
language: eng
source:
identifier: ISSN: 0171-5216 ; E-ISSN: 1432-1335 ; DOI: 10.1007/s00432-010-0934-4
fulltext: fulltext
issn:
  • 1432-1335
  • 14321335
  • 0171-5216
  • 01715216
url: Link


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titleEvidence of the cross talk between Wnt and Notch signaling pathways in non-small-cell lung cancer (NSCLC): Notch3-siRNA weakens the effect of LiCl on the cell cycle of NSCLC cell lines
creatorLi, Chunyan ; Zhang, Ying ; Lu, Yao ; Cui, Zeshi ; Yu, Miao ; Zhang, Siyang ; Xue, Xiaoxia
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descriptionByline: Chunyan Li (1), Ying Zhang (1), Yao Lu (1), Zeshi Cui (1), Miao Yu (1), Siyang Zhang (1), Xiaoxia Xue (1) Keywords: Wnt signaling; Notch signaling; Lung cancer; Cell cycle Abstract: Background Aberrant activations of Wnt and Notch signaling pathways are individually reported to be associated with the pathogenesis of non-small-cell lung cancer (NSCLC). However, the data about the cross talk between the two signaling pathways are still limited. To elucidate potential Wnt/Notch cross talk within NSCLC, we examined the impact of Notch3 activity on LiCl-induced cell cycle changes. Methods The lung cancer cell lines were treated with LiCl, a Wnt activator, in the absence or presence of Notch3-siRNA. Cell cycles and the expression of the regulators of cell cycle, c-MYC, p21 and Skp2 (S phase kinase-associated protein 2) were measured after treatment. Results The treatment with LiCl increased the percent of cells at S phase and G phase and the expression of c-MYC and Skp2 and decreased the expression of p21. Moreover, the expression of Notch3 and its down-stream genes, HES-1 and HEYL, was up-regulated by LiCl. Notch3-siRNA weakened the effect of LiCl on the cell cycle and resulted in attenuation of the LiCl-induced increment of c-MYC and Skp2 and the LiCl-induced decrement of p21. Conclusions These data suggest that Notch3 activation cooperatively takes part in the LiCl-induced cell cycle changes, at least partially, associated with c-MYC, Skp2 and p21. Author Affiliation: (1) Center of the Laboratory Technology and Experimental Medicine, China Medical University, 110001, Shenyang, People's Republic of China Article History: Registration Date: 21/06/2010 Received Date: 18/12/2009 Accepted Date: 21/06/2010 Online Date: 08/07/2010
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