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Comparison of clinicopathological characteristics and prognoses between bilateral and unilateral breast cancer

Byline: Yan-Xia Shi (1,2), Qing Xia (1,2), Rou-Jun Peng (1,2), Zhong-Yu Yuan (1,2), Shu-Sen Wang (1,2), Xin An (1,2), Ye Cao (1,2), Yu-Ting Tan (1,2), Ying Jin (1,2), Xiu-Yu Cai (1,2), Yue-Li Sun (1,2), Xiao-Yu Teng (1,2), Dong-Geng Liu (1,2), Wen-Qi Jiang (1,2) Keywords: Breast cancer; Bilateral br... Full description

Journal Title: Journal of Cancer Research and Clinical Oncology 2012, Vol.138(4), pp.705-714
Main Author: Shi, Yan-Xia
Other Authors: Xia, Qing , Peng, Rou-Jun , Yuan, Zhong-Yu , Wang, Shu-Sen , An, Xin , Cao, Ye , Tan, Yu-Ting , Jin, Ying , Cai, Xiu-Yu , Sun, Yue-Li , Teng, Xiao-Yu , Liu, Dong-Geng , Jiang, Wen-Qi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0171-5216 ; E-ISSN: 1432-1335 ; DOI: 10.1007/s00432-011-1141-7
Link: http://dx.doi.org/10.1007/s00432-011-1141-7
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recordid: springer_jour10.1007/s00432-011-1141-7
title: Comparison of clinicopathological characteristics and prognoses between bilateral and unilateral breast cancer
format: Article
creator:
  • Shi, Yan-Xia
  • Xia, Qing
  • Peng, Rou-Jun
  • Yuan, Zhong-Yu
  • Wang, Shu-Sen
  • An, Xin
  • Cao, Ye
  • Tan, Yu-Ting
  • Jin, Ying
  • Cai, Xiu-Yu
  • Sun, Yue-Li
  • Teng, Xiao-Yu
  • Liu, Dong-Geng
  • Jiang, Wen-Qi
subjects:
  • Breast cancer
  • Bilateral breast cancer
  • Unilateral breast cancer
  • Prognosis
ispartof: Journal of Cancer Research and Clinical Oncology, 2012, Vol.138(4), pp.705-714
description: Byline: Yan-Xia Shi (1,2), Qing Xia (1,2), Rou-Jun Peng (1,2), Zhong-Yu Yuan (1,2), Shu-Sen Wang (1,2), Xin An (1,2), Ye Cao (1,2), Yu-Ting Tan (1,2), Ying Jin (1,2), Xiu-Yu Cai (1,2), Yue-Li Sun (1,2), Xiao-Yu Teng (1,2), Dong-Geng Liu (1,2), Wen-Qi Jiang (1,2) Keywords: Breast cancer; Bilateral breast cancer; Unilateral breast cancer; Prognosis Abstract: Purpose The clinical significance of bilateral breast cancer is unclear and its influence on prognosis is controversial. We compared the characteristics and prognosis of bilateral breast cancer and unilateral breast cancer. Methods Our study included 4,183 patients with breast cancer who were treated at Sun Yat-sen University Cancer Center between January 1, 2000, and December 31, 2007. Bilateral breast cancer was categorized as synchronous (within 3 months) or metachronous (diagnosed after 3 months of first cancer). SPSS was used for data analysis. Results 106 (2.5%) and 31 (0.7%) patients were diagnosed with metachronous and synchronous bilateral cancer. Women with bilateral cancer had more frequent postmenopause, HER-2 negativity, and advanced disease than in patients with unilateral cancer. Young age at diagnosis, invasive lobular carcinoma, ER/PR negativity, HER-2 positivity, radiation, large tumor size (T > 5 cm), and stage III disease of the first cancer were risk factors for contralateral cancer. The 5-year disease-free survival and overall survival rates were 76 and 83% for unilateral cancer, while 32 and 72% for bilateral cancer (P = 0.000 for both). Conclusions Bilateral cancer was associated with shorter disease-free survival and overall survival than unilateral cancer. The prognosis of metachronous bilateral cancer, especially those diagnosed within 2 years after the first cancer was significantly worse than synchronous bilateral cancer. Author Affiliation: (1) Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road, East, Guangzhou, 510060, People's Republic of China (2) State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road, East, Guangzhou, 510060, People's Republic of China Article History: Registration Date: 22/12/2011 Received Date: 18/12/2011 Accepted Date: 22/12/2011 Online Date: 12/01/2012 Article note: Yan-Xia Shi and Qing Xia contributed equally to this work.
language: eng
source:
identifier: ISSN: 0171-5216 ; E-ISSN: 1432-1335 ; DOI: 10.1007/s00432-011-1141-7
fulltext: fulltext
issn:
  • 1432-1335
  • 14321335
  • 0171-5216
  • 01715216
url: Link


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titleComparison of clinicopathological characteristics and prognoses between bilateral and unilateral breast cancer
creatorShi, Yan-Xia ; Xia, Qing ; Peng, Rou-Jun ; Yuan, Zhong-Yu ; Wang, Shu-Sen ; An, Xin ; Cao, Ye ; Tan, Yu-Ting ; Jin, Ying ; Cai, Xiu-Yu ; Sun, Yue-Li ; Teng, Xiao-Yu ; Liu, Dong-Geng ; Jiang, Wen-Qi
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descriptionByline: Yan-Xia Shi (1,2), Qing Xia (1,2), Rou-Jun Peng (1,2), Zhong-Yu Yuan (1,2), Shu-Sen Wang (1,2), Xin An (1,2), Ye Cao (1,2), Yu-Ting Tan (1,2), Ying Jin (1,2), Xiu-Yu Cai (1,2), Yue-Li Sun (1,2), Xiao-Yu Teng (1,2), Dong-Geng Liu (1,2), Wen-Qi Jiang (1,2) Keywords: Breast cancer; Bilateral breast cancer; Unilateral breast cancer; Prognosis Abstract: Purpose The clinical significance of bilateral breast cancer is unclear and its influence on prognosis is controversial. We compared the characteristics and prognosis of bilateral breast cancer and unilateral breast cancer. Methods Our study included 4,183 patients with breast cancer who were treated at Sun Yat-sen University Cancer Center between January 1, 2000, and December 31, 2007. Bilateral breast cancer was categorized as synchronous (within 3 months) or metachronous (diagnosed after 3 months of first cancer). SPSS was used for data analysis. Results 106 (2.5%) and 31 (0.7%) patients were diagnosed with metachronous and synchronous bilateral cancer. Women with bilateral cancer had more frequent postmenopause, HER-2 negativity, and advanced disease than in patients with unilateral cancer. Young age at diagnosis, invasive lobular carcinoma, ER/PR negativity, HER-2 positivity, radiation, large tumor size (T > 5 cm), and stage III disease of the first cancer were risk factors for contralateral cancer. The 5-year disease-free survival and overall survival rates were 76 and 83% for unilateral cancer, while 32 and 72% for bilateral cancer (P = 0.000 for both). Conclusions Bilateral cancer was associated with shorter disease-free survival and overall survival than unilateral cancer. The prognosis of metachronous bilateral cancer, especially those diagnosed within 2 years after the first cancer was significantly worse than synchronous bilateral cancer. Author Affiliation: (1) Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road, East, Guangzhou, 510060, People's Republic of China (2) State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road, East, Guangzhou, 510060, People's Republic of China Article History: Registration Date: 22/12/2011 Received Date: 18/12/2011 Accepted Date: 22/12/2011 Online Date: 12/01/2012 Article note: Yan-Xia Shi and Qing Xia contributed equally to this work.
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