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Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues

N-myc downstream-regulated gene 2 (NDRG2) is believed to be involved in cell growth events. However, its exact function is still unknown. To elucidate the role of this gene, we used an anti-Ndrg2 monoclonal antibody in immunohistochemistry and immunofluorescence assays to analyze the expression patt... Full description

Journal Title: Cell and Tissue Research 2006, Vol.325(1), pp.67-76
Main Author: Hu, Xiao-Lan
Other Authors: Liu, Xin-Ping , Deng, Yan-Chun , Lin, Shu-Xin , Wu, Lin , Zhang, Jian , Wang, Li-Feng , Wang, Xiao-Bin , Li, Xia , Shen, Lan , Zhang, Yuan-Qiang , Yao, Li-Bo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0302-766X ; E-ISSN: 1432-0878 ; DOI: 10.1007/s00441-005-0137-5
Link: http://dx.doi.org/10.1007/s00441-005-0137-5
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recordid: springer_jour10.1007/s00441-005-0137-5
title: Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues
format: Article
creator:
  • Hu, Xiao-Lan
  • Liu, Xin-Ping
  • Deng, Yan-Chun
  • Lin, Shu-Xin
  • Wu, Lin
  • Zhang, Jian
  • Wang, Li-Feng
  • Wang, Xiao-Bin
  • Li, Xia
  • Shen, Lan
  • Zhang, Yuan-Qiang
  • Yao, Li-Bo
subjects:
  • Ndrg2
  • Tissue distribution
  • Embryos
  • Mouse (BALB/c)
ispartof: Cell and Tissue Research, 2006, Vol.325(1), pp.67-76
description: N-myc downstream-regulated gene 2 (NDRG2) is believed to be involved in cell growth events. However, its exact function is still unknown. To elucidate the role of this gene, we used an anti-Ndrg2 monoclonal antibody in immunohistochemistry and immunofluorescence assays to analyze the expression pattern of Ndrg2 protein in mouse embryos at various gestational ages and in a variety of adult mouse tissues. Ndrg2 immunoreactivity was generally localized to the cytoplasm. During mouse development, Ndrg2 expression was observed in many developing tissues and organs including the heart, brain, lung, gut, liver, kidney, skeletal muscle, cartilage, chorion, epidermis, and whisker follicles. Ndrg2 expression was developmentally dynamic, being generally lower in the early stages of development and markedly increasing during later stages. Ndrg2 expression was also observed in a variety of adult mouse tissues, particularly in the heart and brain. This is the first demonstration of Ndrg2 protein expression in both embryonic and adult mouse tissues. Our results suggest that NDRG2 plays important roles in histogenesis and organogenesis.
language: eng
source:
identifier: ISSN: 0302-766X ; E-ISSN: 1432-0878 ; DOI: 10.1007/s00441-005-0137-5
fulltext: fulltext
issn:
  • 1432-0878
  • 14320878
  • 0302-766X
  • 0302766X
url: Link


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titleExpression analysis of the NDRG2 gene in mouse embryonic and adult tissues
creatorHu, Xiao-Lan ; Liu, Xin-Ping ; Deng, Yan-Chun ; Lin, Shu-Xin ; Wu, Lin ; Zhang, Jian ; Wang, Li-Feng ; Wang, Xiao-Bin ; Li, Xia ; Shen, Lan ; Zhang, Yuan-Qiang ; Yao, Li-Bo
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descriptionN-myc downstream-regulated gene 2 (NDRG2) is believed to be involved in cell growth events. However, its exact function is still unknown. To elucidate the role of this gene, we used an anti-Ndrg2 monoclonal antibody in immunohistochemistry and immunofluorescence assays to analyze the expression pattern of Ndrg2 protein in mouse embryos at various gestational ages and in a variety of adult mouse tissues. Ndrg2 immunoreactivity was generally localized to the cytoplasm. During mouse development, Ndrg2 expression was observed in many developing tissues and organs including the heart, brain, lung, gut, liver, kidney, skeletal muscle, cartilage, chorion, epidermis, and whisker follicles. Ndrg2 expression was developmentally dynamic, being generally lower in the early stages of development and markedly increasing during later stages. Ndrg2 expression was also observed in a variety of adult mouse tissues, particularly in the heart and brain. This is the first demonstration of Ndrg2 protein expression in both embryonic and adult mouse tissues. Our results suggest that NDRG2 plays important roles in histogenesis and organogenesis.
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titleExpression analysis of the NDRG2 gene in mouse embryonic and adult tissues
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abstractN-myc downstream-regulated gene 2 (NDRG2) is believed to be involved in cell growth events. However, its exact function is still unknown. To elucidate the role of this gene, we used an anti-Ndrg2 monoclonal antibody in immunohistochemistry and immunofluorescence assays to analyze the expression pattern of Ndrg2 protein in mouse embryos at various gestational ages and in a variety of adult mouse tissues. Ndrg2 immunoreactivity was generally localized to the cytoplasm. During mouse development, Ndrg2 expression was observed in many developing tissues and organs including the heart, brain, lung, gut, liver, kidney, skeletal muscle, cartilage, chorion, epidermis, and whisker follicles. Ndrg2 expression was developmentally dynamic, being generally lower in the early stages of development and markedly increasing during later stages. Ndrg2 expression was also observed in a variety of adult mouse tissues, particularly in the heart and brain. This is the first demonstration of Ndrg2 protein expression in both embryonic and adult mouse tissues. Our results suggest that NDRG2 plays important roles in histogenesis and organogenesis.
copBerlin/Heidelberg
pubSpringer-Verlag
doi10.1007/s00441-005-0137-5
pages67-76
date2006-07