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Rapid capacitive detection of femtomolar levels of bisphenol A using an aptamer-modified disposable microelectrode array

A label-free and single-step method is reported for rapid and highly sensitive detection of bisphenol A (BPA) in aqueous samples. It utilizes an aptamer acting as a probe molecule immobilized on a commercially available array of interdigitated aluminum microelectrodes. BPA was quantified by measurin... Full description

Journal Title: Microchimica Acta 2015, Vol.182(13), pp.2361-2367
Main Author: Cui, Haochen
Other Authors: Wu, Jayne , Eda, Shigetoshi , Chen, Jiangang , Chen, Wei , Zheng, Lei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0026-3672 ; E-ISSN: 1436-5073 ; DOI: 10.1007/s00604-015-1556-y
Link: http://dx.doi.org/10.1007/s00604-015-1556-y
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recordid: springer_jour10.1007/s00604-015-1556-y
title: Rapid capacitive detection of femtomolar levels of bisphenol A using an aptamer-modified disposable microelectrode array
format: Article
creator:
  • Cui, Haochen
  • Wu, Jayne
  • Eda, Shigetoshi
  • Chen, Jiangang
  • Chen, Wei
  • Zheng, Lei
subjects:
  • Capacitive sensing
  • Aptasensor
  • Bisphenol A
  • AC electrokinetics
ispartof: Microchimica Acta, 2015, Vol.182(13), pp.2361-2367
description: A label-free and single-step method is reported for rapid and highly sensitive detection of bisphenol A (BPA) in aqueous samples. It utilizes an aptamer acting as a probe molecule immobilized on a commercially available array of interdigitated aluminum microelectrodes. BPA was quantified by measuring the interfacial capacitance change rate caused by the specific binding between bisphenol A and the immobilized aptamer. The AC signal also induces an AC electrokinetic effect to generate microfluidic motion for enhanced binding. The capacitive aptasensor achieves a limit of detection as low as 10 fM(2.8 fg ⋅  mL − 1 ) with a 20 s response time. The method is inexpensive, highly sensitive, rapid and therefore provides a promising technology for on-site detection of BPA in food and water samples. Graphical Abstract A. AC electrokinetics effect plays a vital role in BPA detection by introducing microfluidic movement to accelerate the molecular transport to the electrode surface. B. The ACEK capacitive aptasensor has a limit of detection as low as 10 fM (2.8 fg ⋅  mL − 1 ) with a 20-s response time.
language: eng
source:
identifier: ISSN: 0026-3672 ; E-ISSN: 1436-5073 ; DOI: 10.1007/s00604-015-1556-y
fulltext: fulltext
issn:
  • 1436-5073
  • 14365073
  • 0026-3672
  • 00263672
url: Link


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titleRapid capacitive detection of femtomolar levels of bisphenol A using an aptamer-modified disposable microelectrode array
creatorCui, Haochen ; Wu, Jayne ; Eda, Shigetoshi ; Chen, Jiangang ; Chen, Wei ; Zheng, Lei
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subjectCapacitive sensing ; Aptasensor ; Bisphenol A ; AC electrokinetics
descriptionA label-free and single-step method is reported for rapid and highly sensitive detection of bisphenol A (BPA) in aqueous samples. It utilizes an aptamer acting as a probe molecule immobilized on a commercially available array of interdigitated aluminum microelectrodes. BPA was quantified by measuring the interfacial capacitance change rate caused by the specific binding between bisphenol A and the immobilized aptamer. The AC signal also induces an AC electrokinetic effect to generate microfluidic motion for enhanced binding. The capacitive aptasensor achieves a limit of detection as low as 10 fM(2.8 fg ⋅  mL − 1 ) with a 20 s response time. The method is inexpensive, highly sensitive, rapid and therefore provides a promising technology for on-site detection of BPA in food and water samples. Graphical Abstract A. AC electrokinetics effect plays a vital role in BPA detection by introducing microfluidic movement to accelerate the molecular transport to the electrode surface. B. The ACEK capacitive aptasensor has a limit of detection as low as 10 fM (2.8 fg ⋅  mL − 1 ) with a 20-s response time.
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0A label-free and single-step method is reported for rapid and highly sensitive detection of bisphenol A (BPA) in aqueous samples. It utilizes an aptamer acting as a probe molecule immobilized on a commercially available array of interdigitated aluminum microelectrodes. BPA was quantified by measuring the interfacial capacitance change rate caused by the specific binding between bisphenol A and the immobilized aptamer. The AC signal also induces an AC electrokinetic effect to generate microfluidic motion for enhanced binding. The capacitive aptasensor achieves a limit of detection as low as 10 fM(2.8 fg ⋅  mL − 1 ) with a 20 s response time. The method is inexpensive, highly sensitive, rapid and therefore provides a promising technology for on-site detection of BPA in food and water samples.
1Graphical Abstract A. AC electrokinetics effect plays a vital role in BPA detection by introducing microfluidic movement to accelerate the molecular transport to the electrode surface.
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abstractA label-free and single-step method is reported for rapid and highly sensitive detection of bisphenol A (BPA) in aqueous samples. It utilizes an aptamer acting as a probe molecule immobilized on a commercially available array of interdigitated aluminum microelectrodes. BPA was quantified by measuring the interfacial capacitance change rate caused by the specific binding between bisphenol A and the immobilized aptamer. The AC signal also induces an AC electrokinetic effect to generate microfluidic motion for enhanced binding. The capacitive aptasensor achieves a limit of detection as low as 10 fM(2.8 fg ⋅  mL − 1 ) with a 20 s response time. The method is inexpensive, highly sensitive, rapid and therefore provides a promising technology for on-site detection of BPA in food and water samples. Graphical Abstract A. AC electrokinetics effect plays a vital role in BPA detection by introducing microfluidic movement to accelerate the molecular transport to the electrode surface. B. The ACEK capacitive aptasensor has a limit of detection as low as 10 fM (2.8 fg ⋅  mL − 1 ) with a 20-s response time.
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