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Biocompatible iron(II)-doped carbon dots as T 1 -weighted magnetic resonance contrast agents and fluorescence imaging probes

The one-pot synthesis of iron-doped carbon quantum dots (Fe-CQDs) for use as both magnetic resonance (MR) and fluorescent (dual-mode) imaging nanoprobes is described. Comprehensive characterizations of the material confirmed the successful doping of the CQDs with Fe(II) ions. The imaging probe has a... Full description

Journal Title: Microchimica Acta 2019, Vol.186(8), pp.1-10
Main Author: Huang, Qing
Other Authors: Liu, Yue , Zheng, Linling , Wu, Liping , Zhou, Zhengyu , Chen, Jiafei , Chen, Wei , Zhao, Huawen
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0026-3672 ; E-ISSN: 1436-5073 ; DOI: 10.1007/s00604-019-3593-4
Link: http://dx.doi.org/10.1007/s00604-019-3593-4
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recordid: springer_jour10.1007/s00604-019-3593-4
title: Biocompatible iron(II)-doped carbon dots as T 1 -weighted magnetic resonance contrast agents and fluorescence imaging probes
format: Article
creator:
  • Huang, Qing
  • Liu, Yue
  • Zheng, Linling
  • Wu, Liping
  • Zhou, Zhengyu
  • Chen, Jiafei
  • Chen, Wei
  • Zhao, Huawen
subjects:
  • -weighted magnetic resonance imaging
  • Fluorescence imaging
  • Dual-modal bioimaging
  • Magnetofluorescent
  • In vivo MRI
  • Biocompatibility
  • Glutathione
  • High longitudinal relaxivity
ispartof: Microchimica Acta, 2019, Vol.186(8), pp.1-10
description: The one-pot synthesis of iron-doped carbon quantum dots (Fe-CQDs) for use as both magnetic resonance (MR) and fluorescent (dual-mode) imaging nanoprobes is described. Comprehensive characterizations of the material confirmed the successful doping of the CQDs with Fe(II) ions. The imaging probe has a longitudinal relaxivity of 3.92 mM −1 ∙s −1 and a low r 2 / r 1 ratio of 1.27, both of which are critical for T 1 -weighted contrast agents. The maximum emission of Fe-CQDs locates at 450 nm under 375 nm excitation, which also can be applied to fluorescence imaging. Biotoxicity assessment showed good biocompatibility of the Fe-CQDs. The in-vitro experiments with A549 cells indicated that the Fe-CQDs are viable candidates as dual-mode (MR/fluorescence) imaging nanoprobes. For in-vivo experiments, they exhibit high contrast efficiency, thereby improving the positive contrast in T 1 -weighted MR images. In-vivo time-dependent MRI of major organs showed that the Fe-CQDs undergo fast glomerular filtration and can evade immuno-absorption due to their ultra-small size and excellent biocompatibility. Graphical abstract Schematic presentation of the synthesis of Fe-CQDs and applications to magnetic resonance and fluorescent dual-mode imaging.
language: eng
source:
identifier: ISSN: 0026-3672 ; E-ISSN: 1436-5073 ; DOI: 10.1007/s00604-019-3593-4
fulltext: fulltext
issn:
  • 1436-5073
  • 14365073
  • 0026-3672
  • 00263672
url: Link


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titleBiocompatible iron(II)-doped carbon dots as T 1 -weighted magnetic resonance contrast agents and fluorescence imaging probes
creatorHuang, Qing ; Liu, Yue ; Zheng, Linling ; Wu, Liping ; Zhou, Zhengyu ; Chen, Jiafei ; Chen, Wei ; Zhao, Huawen
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descriptionThe one-pot synthesis of iron-doped carbon quantum dots (Fe-CQDs) for use as both magnetic resonance (MR) and fluorescent (dual-mode) imaging nanoprobes is described. Comprehensive characterizations of the material confirmed the successful doping of the CQDs with Fe(II) ions. The imaging probe has a longitudinal relaxivity of 3.92 mM −1 ∙s −1 and a low r 2 / r 1 ratio of 1.27, both of which are critical for T 1 -weighted contrast agents. The maximum emission of Fe-CQDs locates at 450 nm under 375 nm excitation, which also can be applied to fluorescence imaging. Biotoxicity assessment showed good biocompatibility of the Fe-CQDs. The in-vitro experiments with A549 cells indicated that the Fe-CQDs are viable candidates as dual-mode (MR/fluorescence) imaging nanoprobes. For in-vivo experiments, they exhibit high contrast efficiency, thereby improving the positive contrast in T 1 -weighted MR images. In-vivo time-dependent MRI of major organs showed that the Fe-CQDs undergo fast glomerular filtration and can evade immuno-absorption due to their ultra-small size and excellent biocompatibility. Graphical abstract Schematic presentation of the synthesis of Fe-CQDs and applications to magnetic resonance and fluorescent dual-mode imaging.
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abstractThe one-pot synthesis of iron-doped carbon quantum dots (Fe-CQDs) for use as both magnetic resonance (MR) and fluorescent (dual-mode) imaging nanoprobes is described. Comprehensive characterizations of the material confirmed the successful doping of the CQDs with Fe(II) ions. The imaging probe has a longitudinal relaxivity of 3.92 mM −1 ∙s −1 and a low r 2 / r 1 ratio of 1.27, both of which are critical for T 1 -weighted contrast agents. The maximum emission of Fe-CQDs locates at 450 nm under 375 nm excitation, which also can be applied to fluorescence imaging. Biotoxicity assessment showed good biocompatibility of the Fe-CQDs. The in-vitro experiments with A549 cells indicated that the Fe-CQDs are viable candidates as dual-mode (MR/fluorescence) imaging nanoprobes. For in-vivo experiments, they exhibit high contrast efficiency, thereby improving the positive contrast in T 1 -weighted MR images. In-vivo time-dependent MRI of major organs showed that the Fe-CQDs undergo fast glomerular filtration and can evade immuno-absorption due to their ultra-small size and excellent biocompatibility. Graphical abstract Schematic presentation of the synthesis of Fe-CQDs and applications to magnetic resonance and fluorescent dual-mode imaging.
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doi10.1007/s00604-019-3593-4
pages1-10
date2019-08