schliessen

Filtern

 

Bibliotheken

Molecularly imprinted polymers for histamine recognition in aqueous environment

Molecularly imprinted polymers (MIP) for histamine using methacrylic acid were developed and recognition mechanisms were thoroughly characterized for the first time in this study. The binding affinity of imprinted polymer with structurally related compounds was studied in organic and aqueous media,... Full description

Journal Title: Amino Acids 2012, Vol.43(5), pp.2113-2124
Main Author: Trikka, Foteini
Other Authors: Yoshimatsu, Keiichi , Ye, Lei , Kyriakidis, Dimitrios
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0939-4451 ; E-ISSN: 1438-2199 ; DOI: 10.1007/s00726-012-1297-8
Link: http://dx.doi.org/10.1007/s00726-012-1297-8
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: springer_jour10.1007/s00726-012-1297-8
title: Molecularly imprinted polymers for histamine recognition in aqueous environment
format: Article
creator:
  • Trikka, Foteini
  • Yoshimatsu, Keiichi
  • Ye, Lei
  • Kyriakidis, Dimitrios
subjects:
  • Aqueous assay
  • Histamine
  • Molecular imprinting
  • Molecular recognition
ispartof: Amino Acids, 2012, Vol.43(5), pp.2113-2124
description: Molecularly imprinted polymers (MIP) for histamine using methacrylic acid were developed and recognition mechanisms were thoroughly characterized for the first time in this study. The binding affinity of imprinted polymer with structurally related compounds was studied in organic and aqueous media, at various conditions. In organic media, MIP was found to bind histamine two and six times more than ranitidine and fluoxetine, respectively, whereas higher selectivity was observed in the case of dimentidene or disodium cromoglycate. The specific binding sites of MIP recognized histamine over l -histidine in aqueous conditions, while higher affinity for histamine compared to ranitidine, disodium cromoglycate, putrescine and to a putrescine analogue was observed. A combination of NMR and UV spectroscopy analyses for investigation of imprinting and recognition properties revealed that strong specific interactions between the functional monomer and histamine in the prepolymerization and in the aqueous solutions were probably responsible for histamine recognition. The preparation of histamine MIPs and elucidation of imprinting and recognition mechanism may serve as useful insight for future application of MIPs.
language: eng
source:
identifier: ISSN: 0939-4451 ; E-ISSN: 1438-2199 ; DOI: 10.1007/s00726-012-1297-8
fulltext: fulltext
issn:
  • 1438-2199
  • 14382199
  • 0939-4451
  • 09394451
url: Link


@attributes
ID1085295644
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1007/s00726-012-1297-8
sourceidspringer_jour
recordidTN_springer_jour10.1007/s00726-012-1297-8
sourcesystemPC
pqid1112680012
display
typearticle
titleMolecularly imprinted polymers for histamine recognition in aqueous environment
creatorTrikka, Foteini ; Yoshimatsu, Keiichi ; Ye, Lei ; Kyriakidis, Dimitrios
ispartofAmino Acids, 2012, Vol.43(5), pp.2113-2124
identifier
subjectAqueous assay ; Histamine ; Molecular imprinting ; Molecular recognition
descriptionMolecularly imprinted polymers (MIP) for histamine using methacrylic acid were developed and recognition mechanisms were thoroughly characterized for the first time in this study. The binding affinity of imprinted polymer with structurally related compounds was studied in organic and aqueous media, at various conditions. In organic media, MIP was found to bind histamine two and six times more than ranitidine and fluoxetine, respectively, whereas higher selectivity was observed in the case of dimentidene or disodium cromoglycate. The specific binding sites of MIP recognized histamine over l -histidine in aqueous conditions, while higher affinity for histamine compared to ranitidine, disodium cromoglycate, putrescine and to a putrescine analogue was observed. A combination of NMR and UV spectroscopy analyses for investigation of imprinting and recognition properties revealed that strong specific interactions between the functional monomer and histamine in the prepolymerization and in the aqueous solutions were probably responsible for histamine recognition. The preparation of histamine MIPs and elucidation of imprinting and recognition mechanism may serve as useful insight for future application of MIPs.
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://dx.doi.org/10.1007/s00726-012-1297-8$$EView_full_text_in_Springer_(Subscribers_only)
search
creatorcontrib
0Trikka, Foteini, A.
1Yoshimatsu, Keiichi, A.
2Ye, Lei, A.
3Kyriakidis, Dimitrios, A.
titleMolecularly imprinted polymers for histamine recognition in aqueous environment
descriptionMolecularly imprinted polymers (MIP) for histamine using methacrylic acid were developed and recognition mechanisms were thoroughly characterized for the first time in this study. The binding affinity of imprinted polymer with structurally related compounds was studied in organic and aqueous media, at various conditions. In organic media, MIP was found to bind histamine two and six times more than ranitidine and fluoxetine, respectively, whereas higher selectivity was observed in the case of dimentidene or disodium cromoglycate. The specific binding sites of MIP recognized histamine over l -histidine in aqueous conditions, while higher affinity for histamine compared to ranitidine, disodium cromoglycate, putrescine and to a putrescine analogue was observed. A combination of NMR and UV spectroscopy analyses for investigation of imprinting and recognition properties revealed that strong specific interactions between the functional monomer and histamine in the prepolymerization and in the aqueous solutions were probably responsible for histamine recognition. The preparation of histamine MIPs and elucidation of imprinting and recognition mechanism may serve as useful insight for future application of MIPs.
subject
0Aqueous assay
1Histamine
2Molecular imprinting
3Molecular recognition
general
010.1007/s00726-012-1297-8
1English
2Springer Science & Business Media B.V.
3SpringerLink
sourceidspringer_jour
recordidspringer_jour10.1007/s00726-012-1297-8
issn
01438-2199
114382199
20939-4451
309394451
rsrctypearticle
creationdate2012
addtitle
0Amino Acids
1The Forum for Amino Acid, Peptide and Protein Research
searchscopespringer_journals_complete
scopespringer_journals_complete
lsr30VSR-Enriched:[pqid, pages]
sort
titleMolecularly imprinted polymers for histamine recognition in aqueous environment
authorTrikka, Foteini ; Yoshimatsu, Keiichi ; Ye, Lei ; Kyriakidis, Dimitrios
creationdate20121100
facets
frbrgroupid3741594895177382246
frbrtype5
languageeng
creationdate2012
topic
0Aqueous Assay
1Histamine
2Molecular Imprinting
3Molecular Recognition
collectionSpringerLink
prefilterarticles
rsrctypearticles
creatorcontrib
0Trikka, Foteini
1Yoshimatsu, Keiichi
2Ye, Lei
3Kyriakidis, Dimitrios
jtitleAmino Acids
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Trikka
1Yoshimatsu
2Ye
3Kyriakidis
aufirst
0Foteini
1A.
2Keiichi
3Lei
4Dimitrios
au
0Trikka, Foteini
1Yoshimatsu, Keiichi
2Ye, Lei
3Kyriakidis, Dimitrios
atitleMolecularly imprinted polymers for histamine recognition in aqueous environment
jtitleAmino Acids
stitleAmino Acids
addtitleThe Forum for Amino Acid, Peptide and Protein Research
risdate201211
volume43
issue5
spage2113
epage2124
issn0939-4451
eissn1438-2199
genrearticle
ristypeJOUR
abstractMolecularly imprinted polymers (MIP) for histamine using methacrylic acid were developed and recognition mechanisms were thoroughly characterized for the first time in this study. The binding affinity of imprinted polymer with structurally related compounds was studied in organic and aqueous media, at various conditions. In organic media, MIP was found to bind histamine two and six times more than ranitidine and fluoxetine, respectively, whereas higher selectivity was observed in the case of dimentidene or disodium cromoglycate. The specific binding sites of MIP recognized histamine over l -histidine in aqueous conditions, while higher affinity for histamine compared to ranitidine, disodium cromoglycate, putrescine and to a putrescine analogue was observed. A combination of NMR and UV spectroscopy analyses for investigation of imprinting and recognition properties revealed that strong specific interactions between the functional monomer and histamine in the prepolymerization and in the aqueous solutions were probably responsible for histamine recognition. The preparation of histamine MIPs and elucidation of imprinting and recognition mechanism may serve as useful insight for future application of MIPs.
copVienna
pubSpringer Vienna
doi10.1007/s00726-012-1297-8
pages2113-2124
date2012-11