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Etanercept in the treatment of rheumatoid arthritis: clinical follow-up over one year by ultrasonography

We evaluated clinically and sonographically the effects of etanercept therapy in patients with rheumatoid arthritis (RA) over 12 months of treatment. Eighteen patients affected by RA who were non-responders or partial responders to disease modifying therapy were commenced on Etanercept treatment. Be... Full description

Journal Title: Clinical Rheumatology 2008, Vol.27(4), pp.491-496
Main Author: Iagnocco, Annamaria
Other Authors: Perella, Chiara , Naredo, Esperanza , Meenagh, Gary , Ceccarelli, Fulvia , Tripodo, Emanuela , Basili, Stefania , Valesini, Guido
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0770-3198 ; E-ISSN: 1434-9949 ; DOI: 10.1007/s10067-007-0738-3
Link: http://dx.doi.org/10.1007/s10067-007-0738-3
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recordid: springer_jour10.1007/s10067-007-0738-3
title: Etanercept in the treatment of rheumatoid arthritis: clinical follow-up over one year by ultrasonography
format: Article
creator:
  • Iagnocco, Annamaria
  • Perella, Chiara
  • Naredo, Esperanza
  • Meenagh, Gary
  • Ceccarelli, Fulvia
  • Tripodo, Emanuela
  • Basili, Stefania
  • Valesini, Guido
subjects:
  • Etanercept
  • Follow-up
  • Rheumatoid arthritis
  • Ultrasonography
ispartof: Clinical Rheumatology, 2008, Vol.27(4), pp.491-496
description: We evaluated clinically and sonographically the effects of etanercept therapy in patients with rheumatoid arthritis (RA) over 12 months of treatment. Eighteen patients affected by RA who were non-responders or partial responders to disease modifying therapy were commenced on Etanercept treatment. Before starting therapy (T0) and at 12 months (T1), the following parameters were evaluated: erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), visual analogue scale (VAS) for pain, number of painful and swollen joints, health assessment questionnaire (HAQ) and disease activity score in 28 joints (DAS 28). Musculoskeletal ultrasound (US) was performed in the following joints: second and fifth metacarpophalangeal, third interphalangeal, wrist and knee joints and a semiquantitative score (0–3) calculated and used to indicate the presence of a localised inflammatory process (synovitis, tenosynovitis, bursitis) and/or structural damage (bone erosion and cartilaginous change). An overall score was calculated based on the sum of the single scores to obtain a comprehensive score indicative of the global pathological change. The US global scores significantly reduced between T0 and T1 ( p  
language: eng
source:
identifier: ISSN: 0770-3198 ; E-ISSN: 1434-9949 ; DOI: 10.1007/s10067-007-0738-3
fulltext: fulltext
issn:
  • 1434-9949
  • 14349949
  • 0770-3198
  • 07703198
url: Link


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