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Validation of glutathione quantitation from STEAM spectra against edited 1 H NMR spectroscopy at 4T: application to schizophrenia

Objective : Quantitation of glutathione (GSH) in the human brain in vivo using short echo time 1 H NMR spectroscopy is challenging because GSH resonances are not easily resolved. The main objective of this study was to validate such quantitation in a clinically relevant population using the resolved... Full description

Journal Title: Magnetic Resonance Materials in Physics Biology and Medicine, 2005, Vol.18(5), pp.276-282
Main Author: Terpstra, Melissa
Other Authors: Vaughan, T. , Ugurbil, Kamil , Lim, Kelvin , Schulz, S. , Gruetter, Rolf
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0968-5243 ; E-ISSN: 1352-8661 ; DOI: 10.1007/s10334-005-0012-0
Link: http://dx.doi.org/10.1007/s10334-005-0012-0
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recordid: springer_jour10.1007/s10334-005-0012-0
title: Validation of glutathione quantitation from STEAM spectra against edited 1 H NMR spectroscopy at 4T: application to schizophrenia
format: Article
creator:
  • Terpstra, Melissa
  • Vaughan, T.
  • Ugurbil, Kamil
  • Lim, Kelvin
  • Schulz, S.
  • Gruetter, Rolf
subjects:
  • Glutathione
  • Magnetic resonance spectroscopy
  • Schizophrenia
ispartof: Magnetic Resonance Materials in Physics, Biology and Medicine, 2005, Vol.18(5), pp.276-282
description: Objective : Quantitation of glutathione (GSH) in the human brain in vivo using short echo time 1 H NMR spectroscopy is challenging because GSH resonances are not easily resolved. The main objective of this study was to validate such quantitation in a clinically relevant population using the resolved GSH resonances provided by edited spectroscopy. A secondary objective was to compare several of the neurochemical concentrations quantified along with GSH using LCModel analysis of short echo time spectra in schizophrenia versus control. : GSH was quantified at 4T from short echo STEAM spectra and MEGA-PRESS edited spectra from identical volumes of interest (anterior cingulate) in ten volunteers. Neurochemical profiles were quantified in nine controls and 13 medicated schizophrenic patients. : GSH concentrations as quantified using STEAM, 1.6 ± 0.4 μmol/g (mean ± SD, =10), were within error of those quantified using edited spectra, 1.4 ± 0.4 μmol/g, and were not different (=0.4). None of the neurochemical measurements reached sufficient statistical power to detect differences smaller than 10% in schizophrenia versus control. As such, no differences were observed. : Human brain GSH concentrations can be quantified in a clinical setting using short-echo time STEAM spectra at 4T.
language: eng
source:
identifier: ISSN: 0968-5243 ; E-ISSN: 1352-8661 ; DOI: 10.1007/s10334-005-0012-0
fulltext: fulltext
issn:
  • 1352-8661
  • 13528661
  • 0968-5243
  • 09685243
url: Link


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titleValidation of glutathione quantitation from STEAM spectra against edited 1 H NMR spectroscopy at 4T: application to schizophrenia
creatorTerpstra, Melissa ; Vaughan, T. ; Ugurbil, Kamil ; Lim, Kelvin ; Schulz, S. ; Gruetter, Rolf
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subjectGlutathione ; Magnetic resonance spectroscopy ; Schizophrenia
descriptionObjective : Quantitation of glutathione (GSH) in the human brain in vivo using short echo time 1 H NMR spectroscopy is challenging because GSH resonances are not easily resolved. The main objective of this study was to validate such quantitation in a clinically relevant population using the resolved GSH resonances provided by edited spectroscopy. A secondary objective was to compare several of the neurochemical concentrations quantified along with GSH using LCModel analysis of short echo time spectra in schizophrenia versus control. : GSH was quantified at 4T from short echo STEAM spectra and MEGA-PRESS edited spectra from identical volumes of interest (anterior cingulate) in ten volunteers. Neurochemical profiles were quantified in nine controls and 13 medicated schizophrenic patients. : GSH concentrations as quantified using STEAM, 1.6 ± 0.4 μmol/g (mean ± SD, =10), were within error of those quantified using edited spectra, 1.4 ± 0.4 μmol/g, and were not different (=0.4). None of the neurochemical measurements reached sufficient statistical power to detect differences smaller than 10% in schizophrenia versus control. As such, no differences were observed. : Human brain GSH concentrations can be quantified in a clinical setting using short-echo time STEAM spectra at 4T.
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abstractObjective : Quantitation of glutathione (GSH) in the human brain in vivo using short echo time 1 H NMR spectroscopy is challenging because GSH resonances are not easily resolved. The main objective of this study was to validate such quantitation in a clinically relevant population using the resolved GSH resonances provided by edited spectroscopy. A secondary objective was to compare several of the neurochemical concentrations quantified along with GSH using LCModel analysis of short echo time spectra in schizophrenia versus control. : GSH was quantified at 4T from short echo STEAM spectra and MEGA-PRESS edited spectra from identical volumes of interest (anterior cingulate) in ten volunteers. Neurochemical profiles were quantified in nine controls and 13 medicated schizophrenic patients. : GSH concentrations as quantified using STEAM, 1.6 ± 0.4 μmol/g (mean ± SD, =10), were within error of those quantified using edited spectra, 1.4 ± 0.4 μmol/g, and were not different (=0.4). None of the neurochemical measurements reached sufficient statistical power to detect differences smaller than 10% in schizophrenia versus control. As such, no differences were observed. : Human brain GSH concentrations can be quantified in a clinical setting using short-echo time STEAM spectra at 4T.
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doi10.1007/s10334-005-0012-0
pages276-282
date2005-10