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Can Molecular Imaging Enable Personalized Diagnostics? An Example Using Magnetomotive Photoacoustic Imaging

The advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in... Full description

Journal Title: Annals of Biomedical Engineering 2013, Vol.41(11), pp.2237-2247
Main Author: O’Donnell, Matthew
Other Authors: Wei, Chen-wei , Xia, Jinjun , Pelivanov, Ivan , Jia, Congxian , Huang, Sheng-Wen , Hu, Xiaoge , Gao, Xiaohu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0090-6964 ; E-ISSN: 1573-9686 ; DOI: 10.1007/s10439-013-0901-8
Link: http://dx.doi.org/10.1007/s10439-013-0901-8
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recordid: springer_jour10.1007/s10439-013-0901-8
title: Can Molecular Imaging Enable Personalized Diagnostics? An Example Using Magnetomotive Photoacoustic Imaging
format: Article
creator:
  • O’Donnell, Matthew
  • Wei, Chen-wei
  • Xia, Jinjun
  • Pelivanov, Ivan
  • Jia, Congxian
  • Huang, Sheng-Wen
  • Hu, Xiaoge
  • Gao, Xiaohu
subjects:
  • Personalized healthcare
  • Targeted molecular diagnosis and therapy
  • Composite contrast agent
  • Multifunctional nanoparticle
  • Background suppression
  • Circulating tumor cells
ispartof: Annals of Biomedical Engineering, 2013, Vol.41(11), pp.2237-2247
description: The advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous background with strong optical scattering and absorption remains a big challenge. For example, differentiating circulating tumor cells in vivo (typically fewer than 10 cells/mL for an active tumor) among billions of erythrocytes in the blood is nearly impossible. In this paper, a newly developed technique, magnetomotive photoacoustic (mmPA) imaging, which can greatly increase the sensitivity and specificity of sensing targeted cells or molecular interactions, is reviewed. Its primary advantage is suppression of background signals through magnetic enrichment/manipulation with simultaneous PA detection of magnetic contrast agent targeted objects. Results from phantom and in vitro studies demonstrate the capability of mmPA imaging to differentiate regions targeted with magnetic nanoparticles from the background, and to trap and sensitively detect targeted cells at a concentration of a single cell per milliliter in a flow system mimicking a human peripheral artery. This technique provides an example of the ways in which molecular imaging can potentially enable robust molecular diagnosis and treatment, and accelerate the translation of molecular medicine into the clinic.
language: eng
source:
identifier: ISSN: 0090-6964 ; E-ISSN: 1573-9686 ; DOI: 10.1007/s10439-013-0901-8
fulltext: fulltext
issn:
  • 1573-9686
  • 15739686
  • 0090-6964
  • 00906964
url: Link


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titleCan Molecular Imaging Enable Personalized Diagnostics? An Example Using Magnetomotive Photoacoustic Imaging
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subjectPersonalized healthcare ; Targeted molecular diagnosis and therapy ; Composite contrast agent ; Multifunctional nanoparticle ; Background suppression ; Circulating tumor cells
descriptionThe advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous background with strong optical scattering and absorption remains a big challenge. For example, differentiating circulating tumor cells in vivo (typically fewer than 10 cells/mL for an active tumor) among billions of erythrocytes in the blood is nearly impossible. In this paper, a newly developed technique, magnetomotive photoacoustic (mmPA) imaging, which can greatly increase the sensitivity and specificity of sensing targeted cells or molecular interactions, is reviewed. Its primary advantage is suppression of background signals through magnetic enrichment/manipulation with simultaneous PA detection of magnetic contrast agent targeted objects. Results from phantom and in vitro studies demonstrate the capability of mmPA imaging to differentiate regions targeted with magnetic nanoparticles from the background, and to trap and sensitively detect targeted cells at a concentration of a single cell per milliliter in a flow system mimicking a human peripheral artery. This technique provides an example of the ways in which molecular imaging can potentially enable robust molecular diagnosis and treatment, and accelerate the translation of molecular medicine into the clinic.
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titleCan Molecular Imaging Enable Personalized Diagnostics? An Example Using Magnetomotive Photoacoustic Imaging
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abstractThe advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous background with strong optical scattering and absorption remains a big challenge. For example, differentiating circulating tumor cells in vivo (typically fewer than 10 cells/mL for an active tumor) among billions of erythrocytes in the blood is nearly impossible. In this paper, a newly developed technique, magnetomotive photoacoustic (mmPA) imaging, which can greatly increase the sensitivity and specificity of sensing targeted cells or molecular interactions, is reviewed. Its primary advantage is suppression of background signals through magnetic enrichment/manipulation with simultaneous PA detection of magnetic contrast agent targeted objects. Results from phantom and in vitro studies demonstrate the capability of mmPA imaging to differentiate regions targeted with magnetic nanoparticles from the background, and to trap and sensitively detect targeted cells at a concentration of a single cell per milliliter in a flow system mimicking a human peripheral artery. This technique provides an example of the ways in which molecular imaging can potentially enable robust molecular diagnosis and treatment, and accelerate the translation of molecular medicine into the clinic.
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pubSpringer US
doi10.1007/s10439-013-0901-8
pages2237-2247
date2013-11