schliessen

Filtern

 

Bibliotheken

Polycyclic aromatic hydrocarbon (PAH)–DNA adducts and breast cancer: modification by gene promoter methylation in a population-based study

Byline: Alexandra J. White (1), Jia Chen (2,3,4), Lauren E. McCullough (1), Xinran Xu (5), Yoon Hee Cho (6), Susan L. Teitelbaum (2), Alfred I. Neugut (7,8), Mary Beth Terry (7), Hanina Hibshoosh (9), Regina M. Santella (6), Marilie D. Gammon (1) Keywords: Polycyclic aromatic hydrocarbons; Breast ca... Full description

Journal Title: Cancer Causes & Control 2015, Vol.26(12), pp.1791-1802
Main Author: White, Alexandra
Other Authors: Chen, Jia , McCullough, Lauren , Xu, Xinran , Cho, Yoon , Teitelbaum, Susan , Neugut, Alfred , Terry, Mary , Hibshoosh, Hanina , Santella, Regina , Gammon, Marilie
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0957-5243 ; E-ISSN: 1573-7225 ; DOI: 10.1007/s10552-015-0672-7
Link: http://dx.doi.org/10.1007/s10552-015-0672-7
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: springer_jour10.1007/s10552-015-0672-7
title: Polycyclic aromatic hydrocarbon (PAH)–DNA adducts and breast cancer: modification by gene promoter methylation in a population-based study
format: Article
creator:
  • White, Alexandra
  • Chen, Jia
  • McCullough, Lauren
  • Xu, Xinran
  • Cho, Yoon
  • Teitelbaum, Susan
  • Neugut, Alfred
  • Terry, Mary
  • Hibshoosh, Hanina
  • Santella, Regina
  • Gammon, Marilie
subjects:
  • Polycyclic aromatic hydrocarbons
  • Breast cancer
  • DNA methylation
ispartof: Cancer Causes & Control, 2015, Vol.26(12), pp.1791-1802
description: Byline: Alexandra J. White (1), Jia Chen (2,3,4), Lauren E. McCullough (1), Xinran Xu (5), Yoon Hee Cho (6), Susan L. Teitelbaum (2), Alfred I. Neugut (7,8), Mary Beth Terry (7), Hanina Hibshoosh (9), Regina M. Santella (6), Marilie D. Gammon (1) Keywords: Polycyclic aromatic hydrocarbons; Breast cancer; DNA methylation Abstract: Purpose Polycyclic aromatic hydrocarbon (PAH)--DNA adducts have been associated with breast cancer incidence. Aberrant changes in DNA methylation may be an early event in carcinogenesis. However, possible relations between PAH--DNA adducts, methylation, and breast cancer are unknown. The objectives of this study were to (1) assess associations between PAH--DNA adducts, and breast cancer, stratified by DNA methylation markers and (2) examine interactions between adducts and DNA methylation in association with breast cancer and tumor subtype. Methods In a population-based case--control study, promoter methylation of 13 breast cancer-related genes was measured in tumor tissue (n = 765--851 cases). Blood DNA from breast cancer cases (n = 873) and controls (n = 941) was used to assess PAH--DNA adducts and global methylation. Logistic regression was used to estimate adjusted odds ratios (ORs) and 95 % confidence intervals (CI) and the ratio of the OR (ROR) was used to assess heterogeneity. Results Women with detectable PAH--DNA adducts and methylated RAR[beta] (ROR 2.69, 95 % CI 1.02--7.12 p for interaction = 0.03) or APC (ROR 1.76, 95 % CI 0.87--3.58 p for interaction = 0.09) genes were more likely to have hormone receptor-positive tumors than other subtypes. Interactions with other methylation markers were not apparent (p a[yen] 0.10). The association between adducts and breast cancer did not vary by methylation status of the tumor nor did adducts associate with global methylation in the controls. Conclusions Gene-specific methylation of RAR[beta], and perhaps APC, may interact with PAH--DNA adducts to increase risk of hormone receptor-positive breast cancer. There was little evidence that adducts were associated with or interacted with other methylation markers of interest. Author Affiliation: (1) Department of Epidemiology, University of North Carolina, CB 7435, McGavran-Greenberg Hall, Chapel Hill, NC, 27599-7435, USA (2) Departments of Preventive Medicine, Ichan School of Medicine at Mt. Sinai, New York, NY, USA (3) Departments of Oncological Science, Ichan School of Medicine at Mt. Sinai, New York, NY, USA (4) Departments of Pedi
language: eng
source:
identifier: ISSN: 0957-5243 ; E-ISSN: 1573-7225 ; DOI: 10.1007/s10552-015-0672-7
fulltext: fulltext
issn:
  • 1573-7225
  • 15737225
  • 0957-5243
  • 09575243
url: Link


@attributes
ID690657656
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1007/s10552-015-0672-7
sourceidspringer_jour
recordidTN_springer_jour10.1007/s10552-015-0672-7
sourcesystemPC
pqid1746892780
galeid433123713
display
typearticle
titlePolycyclic aromatic hydrocarbon (PAH)–DNA adducts and breast cancer: modification by gene promoter methylation in a population-based study
creatorWhite, Alexandra ; Chen, Jia ; McCullough, Lauren ; Xu, Xinran ; Cho, Yoon ; Teitelbaum, Susan ; Neugut, Alfred ; Terry, Mary ; Hibshoosh, Hanina ; Santella, Regina ; Gammon, Marilie
ispartofCancer Causes & Control, 2015, Vol.26(12), pp.1791-1802
identifier
subjectPolycyclic aromatic hydrocarbons ; Breast cancer ; DNA methylation
languageeng
source
descriptionByline: Alexandra J. White (1), Jia Chen (2,3,4), Lauren E. McCullough (1), Xinran Xu (5), Yoon Hee Cho (6), Susan L. Teitelbaum (2), Alfred I. Neugut (7,8), Mary Beth Terry (7), Hanina Hibshoosh (9), Regina M. Santella (6), Marilie D. Gammon (1) Keywords: Polycyclic aromatic hydrocarbons; Breast cancer; DNA methylation Abstract: Purpose Polycyclic aromatic hydrocarbon (PAH)--DNA adducts have been associated with breast cancer incidence. Aberrant changes in DNA methylation may be an early event in carcinogenesis. However, possible relations between PAH--DNA adducts, methylation, and breast cancer are unknown. The objectives of this study were to (1) assess associations between PAH--DNA adducts, and breast cancer, stratified by DNA methylation markers and (2) examine interactions between adducts and DNA methylation in association with breast cancer and tumor subtype. Methods In a population-based case--control study, promoter methylation of 13 breast cancer-related genes was measured in tumor tissue (n = 765--851 cases). Blood DNA from breast cancer cases (n = 873) and controls (n = 941) was used to assess PAH--DNA adducts and global methylation. Logistic regression was used to estimate adjusted odds ratios (ORs) and 95 % confidence intervals (CI) and the ratio of the OR (ROR) was used to assess heterogeneity. Results Women with detectable PAH--DNA adducts and methylated RAR[beta] (ROR 2.69, 95 % CI 1.02--7.12 p for interaction = 0.03) or APC (ROR 1.76, 95 % CI 0.87--3.58 p for interaction = 0.09) genes were more likely to have hormone receptor-positive tumors than other subtypes. Interactions with other methylation markers were not apparent (p a[yen] 0.10). The association between adducts and breast cancer did not vary by methylation status of the tumor nor did adducts associate with global methylation in the controls. Conclusions Gene-specific methylation of RAR[beta], and perhaps APC, may interact with PAH--DNA adducts to increase risk of hormone receptor-positive breast cancer. There was little evidence that adducts were associated with or interacted with other methylation markers of interest. Author Affiliation: (1) Department of Epidemiology, University of North Carolina, CB 7435, McGavran-Greenberg Hall, Chapel Hill, NC, 27599-7435, USA (2) Departments of Preventive Medicine, Ichan School of Medicine at Mt. Sinai, New York, NY, USA (3) Departments of Oncological Science, Ichan School of Medicine at Mt. Sinai, New York, NY, USA (4) Departments of Pediatrics, Ichan School of Medicine at Mt. Sinai, New York, NY, USA (5) Research Center for Translational Medicine, Shanghai East Hospital of Tongji University School of Medicine, Shanghai, China (6) Department of Environmental Health Sciences, Columbia University, New York, NY, USA (7) Department of Epidemiology, Columbia University, New York, NY, USA (8) Department of Medicine, Columbia University, New York, NY, USA (9) Department of Pathology, Columbia University, New York, NY, USA Article History: Registration Date: 16/09/2015 Received Date: 16/04/2015 Accepted Date: 16/09/2015 Online Date: 25/09/2015 Article note: Electronic supplementary material The online version of this article (doi: 10.1007/s10552-015-0672-7) contains supplementary material, which is available to authorized users.
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://dx.doi.org/10.1007/s10552-015-0672-7$$EView_full_text_in_Springer_(Subscribers_only)
search
creatorcontrib
0White, Alexandra, J.
1Chen, Jia, E.
2McCullough, Lauren, Hee
3Xu, Xinran, L.
4Cho, Yoon, I.
5Teitelbaum, Susan, Beth
6Neugut, Alfred, M.
7Terry, Mary, D.
8Hibshoosh, Hanina, D.
9Santella, Regina, D.
10Gammon, Marilie, D.
titlePolycyclic aromatic hydrocarbon (PAH)–DNA adducts and breast cancer: modification by gene promoter methylation in a population-based study
subject
0Polycyclic aromatic hydrocarbons
1Breast cancer
2DNA methylation
general
010.1007/s10552-015-0672-7
1English
2Springer Science & Business Media B.V.
3SpringerLink
sourceidspringer_jour
recordidspringer_jour10.1007/s10552-015-0672-7
issn
01573-7225
115737225
20957-5243
309575243
rsrctypearticle
creationdate2015
addtitle
0Cancer Causes & Control
1An International Journal of Studies of Cancer in Human Populations
2Cancer Causes Control
searchscopespringer_journals_complete
scopespringer_journals_complete
lsr30VSR-Enriched:[pages, galeid, description, pqid]
sort
titlePolycyclic aromatic hydrocarbon (PAH)–DNA adducts and breast cancer: modification by gene promoter methylation in a population-based study
authorWhite, Alexandra ; Chen, Jia ; McCullough, Lauren ; Xu, Xinran ; Cho, Yoon ; Teitelbaum, Susan ; Neugut, Alfred ; Terry, Mary ; Hibshoosh, Hanina ; Santella, Regina ; Gammon, Marilie
creationdate20151200
facets
frbrgroupid8272750464795637985
frbrtype5
languageeng
creationdate2015
topic
0Polycyclic Aromatic Hydrocarbons
1Breast Cancer
2Dna Methylation
collectionSpringerLink
prefilterarticles
rsrctypearticles
creatorcontrib
0White, Alexandra
1Chen, Jia
2McCullough, Lauren
3Xu, Xinran
4Cho, Yoon
5Teitelbaum, Susan
6Neugut, Alfred
7Terry, Mary
8Hibshoosh, Hanina
9Santella, Regina
10Gammon, Marilie
jtitleCancer Causes &Amp; Control
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0White
1Chen
2McCullough
3Xu
4Cho
5Teitelbaum
6Neugut
7Terry
8Hibshoosh
9Santella
10Gammon
aufirst
0Alexandra
1J.
2Jia
3Lauren
4E.
5Xinran
6Yoon
7Hee
8Susan
9L.
10Alfred
11I.
12Mary
13Beth
14Hanina
15Regina
16M.
17Marilie
18D.
au
0White, Alexandra
1Chen, Jia
2McCullough, Lauren
3Xu, Xinran
4Cho, Yoon
5Teitelbaum, Susan
6Neugut, Alfred
7Terry, Mary
8Hibshoosh, Hanina
9Santella, Regina
10Gammon, Marilie
atitlePolycyclic aromatic hydrocarbon (PAH)–DNA adducts and breast cancer: modification by gene promoter methylation in a population-based study
jtitleCancer Causes & Control
stitleCancer Causes Control
addtitleAn International Journal of Studies of Cancer in Human Populations
risdate201512
volume26
issue12
spage1791
epage1802
issn0957-5243
eissn1573-7225
genrearticle
ristypeJOUR
copCham
pubSpringer International Publishing
doi10.1007/s10552-015-0672-7
pages1791-1802
date2015-12