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Prevalence and current therapy in chronic liver disorders

Byline: Muhammad Daniyal (1), Muhammad Akram (2), Rida Zainab (2), Naveed Munir (3), Aamir Sharif (4), Syed Muhammad Ali Shah (2), Bin Liu (5), Wei Wang (1) Keywords: Liver disorders; Allopathic medicine; Side effects; Medicinal plants; Hepatoprotective activity; Efficacy; Literature review Abstract... Full description

Journal Title: Inflammopharmacology 2019, Vol.27(2), pp.213-231
Main Author: Daniyal, Muhammad
Other Authors: Akram, Muhammad , Zainab, Rida , Munir, Naveed , Sharif, Aamir , Shah, Syed , Liu, Bin , Wang, Wei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0925-4692 ; E-ISSN: 1568-5608 ; DOI: 10.1007/s10787-019-00562-z
Link: http://dx.doi.org/10.1007/s10787-019-00562-z
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recordid: springer_jour10.1007/s10787-019-00562-z
title: Prevalence and current therapy in chronic liver disorders
format: Article
creator:
  • Daniyal, Muhammad
  • Akram, Muhammad
  • Zainab, Rida
  • Munir, Naveed
  • Sharif, Aamir
  • Shah, Syed
  • Liu, Bin
  • Wang, Wei
subjects:
  • Liver disorders
  • Allopathic medicine
  • Side effects
  • Medicinal plants
  • Hepatoprotective activity
  • Efficacy
  • Literature review
ispartof: Inflammopharmacology, 2019, Vol.27(2), pp.213-231
description: Byline: Muhammad Daniyal (1), Muhammad Akram (2), Rida Zainab (2), Naveed Munir (3), Aamir Sharif (4), Syed Muhammad Ali Shah (2), Bin Liu (5), Wei Wang (1) Keywords: Liver disorders; Allopathic medicine; Side effects; Medicinal plants; Hepatoprotective activity; Efficacy; Literature review Abstract: Background Herbal medicine plays an important role in health, particularly in remote parts of developing areas with few health facilities. According to WHO estimates, about three-quarters of the world's population currently use herbs or traditional medicines to treat various ailments, including liver diseases. Several studies have found that the use of medicinal plants was effective in the treatment of infectious and non-infectious diseases. Hepatitis and liver cirrhosis associated with many clinical manifestations can be treated with allopathic medicines, but reports of a number of side effects including immunosuppression, bone marrow suppression, and renal complications have motivated researchers to explore more natural herbal medicines with low or no side effects and with high efficacy in treating hepatic diseases. Methods Databases including PubMed, Medline, and Google Scholar were searched for findings on the hepatoprotective effects of plants. Results Various medicinal plants are used for the treatment of liver disorders. The range of alternative therapies is huge, and they are used worldwide, either as part of primary health care or in combination with conventional medicine. Hepatoprotective plants contain a variety of chemical constituents including flavonoids, alkaloids, glycosides, carotenoids, coumarins, phenols, essential oil, organic acids, monoterpenes, xanthenes, lignans, and lipids. Conclusion This review shows that numerous plants are found to contain hepatoprotective compounds. However, further studies are needed to determine their association with existing regimes of antiviral medicines and to develop evidence-based alternative medicine to cure different kinds of liver disease in humans. Author Affiliation: (1) 0000 0004 1765 5169, grid.488482.a, TCM and Ethnomedicine Innovation and Development International Laboratory, School of Pharmacy, Innovative Materia Medica Research Institute, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China (2) 0000 0004 0637 891X, grid.411786.d, Department of Eastern Medicine, Directorate of Medical Sciences, Government College University, Faisalabad, Pakistan (3) 0000 0004 0637 89
language: eng
source:
identifier: ISSN: 0925-4692 ; E-ISSN: 1568-5608 ; DOI: 10.1007/s10787-019-00562-z
fulltext: fulltext
issn:
  • 1568-5608
  • 15685608
  • 0925-4692
  • 09254692
url: Link


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descriptionByline: Muhammad Daniyal (1), Muhammad Akram (2), Rida Zainab (2), Naveed Munir (3), Aamir Sharif (4), Syed Muhammad Ali Shah (2), Bin Liu (5), Wei Wang (1) Keywords: Liver disorders; Allopathic medicine; Side effects; Medicinal plants; Hepatoprotective activity; Efficacy; Literature review Abstract: Background Herbal medicine plays an important role in health, particularly in remote parts of developing areas with few health facilities. According to WHO estimates, about three-quarters of the world's population currently use herbs or traditional medicines to treat various ailments, including liver diseases. Several studies have found that the use of medicinal plants was effective in the treatment of infectious and non-infectious diseases. Hepatitis and liver cirrhosis associated with many clinical manifestations can be treated with allopathic medicines, but reports of a number of side effects including immunosuppression, bone marrow suppression, and renal complications have motivated researchers to explore more natural herbal medicines with low or no side effects and with high efficacy in treating hepatic diseases. Methods Databases including PubMed, Medline, and Google Scholar were searched for findings on the hepatoprotective effects of plants. Results Various medicinal plants are used for the treatment of liver disorders. The range of alternative therapies is huge, and they are used worldwide, either as part of primary health care or in combination with conventional medicine. Hepatoprotective plants contain a variety of chemical constituents including flavonoids, alkaloids, glycosides, carotenoids, coumarins, phenols, essential oil, organic acids, monoterpenes, xanthenes, lignans, and lipids. Conclusion This review shows that numerous plants are found to contain hepatoprotective compounds. However, further studies are needed to determine their association with existing regimes of antiviral medicines and to develop evidence-based alternative medicine to cure different kinds of liver disease in humans. Author Affiliation: (1) 0000 0004 1765 5169, grid.488482.a, TCM and Ethnomedicine Innovation and Development International Laboratory, School of Pharmacy, Innovative Materia Medica Research Institute, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China (2) 0000 0004 0637 891X, grid.411786.d, Department of Eastern Medicine, Directorate of Medical Sciences, Government College University, Faisalabad, Pakistan (3) 0000 0004 0637 891X, grid.411786.d, Department of Biochemistry and College of Allied health professionals, Directorate of Medical sciences, Government College University, Faisalabad, Pakistan (4) 0000 0004 0609 4693, grid.412782.a, Department of Pathology, Faculty of Medical and Health Sciences, University of Sargodha, Sargodha, Pakistan (5) grid.67293.39, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha, 410082, China Article History: Registration Date: 03/01/2019 Received Date: 10/09/2018 Accepted Date: 03/01/2019 Online Date: 08/02/2019
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