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Synergistic cytotoxicity of low-energy ultrasound and innovative mesoporous silica-based sensitive nanoagents

Low-energy ultrasound (LEUS) shows distinct potential as a safe therapeutic strategy for cancer treatment. Herein, mesoporous silica nanoparticles with closed-end cavities as sensitive nanoagents are prepared for effective cancer cell killing, when synergistically combined with mild LEUS (1 MHz, ≤1.... Full description

Journal Title: Journal of Materials Science 2014, Vol.49(10), pp.3665-3673
Main Author: Zhao, Yang
Other Authors: Zhu, Yingchun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0022-2461 ; E-ISSN: 1573-4803 ; DOI: 10.1007/s10853-014-8073-y
Link: http://dx.doi.org/10.1007/s10853-014-8073-y
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recordid: springer_jour10.1007/s10853-014-8073-y
title: Synergistic cytotoxicity of low-energy ultrasound and innovative mesoporous silica-based sensitive nanoagents
format: Article
creator:
  • Zhao, Yang
  • Zhu, Yingchun
subjects:
  • Silicon Dioxide – Health Aspects
ispartof: Journal of Materials Science, 2014, Vol.49(10), pp.3665-3673
description: Low-energy ultrasound (LEUS) shows distinct potential as a safe therapeutic strategy for cancer treatment. Herein, mesoporous silica nanoparticles with closed-end cavities as sensitive nanoagents are prepared for effective cancer cell killing, when synergistically combined with mild LEUS (1 MHz, ≤1.0 W cm −2 ). The closed-end cavities can entrap gas bubbles, and provide a large number of cavitation nucleation sites, which could lead to drastically amplify ultrasonic cavitation effect by responding to the mild LEUS (1 MHz, ≤1.0 W cm −2 ). Significant killing effect against cancer cells is observed, when cells are treated by synergetic combination of mild LEUS and the nanoagents with closed-end cavities, showing distinct dose dependency on the nanoagents and irradiation intensity. Nevertheless, the killing effect is disappeared when the closed-end cavities are destructed. Moreover, no obvious cytotoxicity is observed when either the nanoagents or the LEUS is applied alone. The research may open up application opportunities of mild low-energy ultrasound for cancer therapy.
language: eng
source:
identifier: ISSN: 0022-2461 ; E-ISSN: 1573-4803 ; DOI: 10.1007/s10853-014-8073-y
fulltext: fulltext
issn:
  • 1573-4803
  • 15734803
  • 0022-2461
  • 00222461
url: Link


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descriptionLow-energy ultrasound (LEUS) shows distinct potential as a safe therapeutic strategy for cancer treatment. Herein, mesoporous silica nanoparticles with closed-end cavities as sensitive nanoagents are prepared for effective cancer cell killing, when synergistically combined with mild LEUS (1 MHz, ≤1.0 W cm −2 ). The closed-end cavities can entrap gas bubbles, and provide a large number of cavitation nucleation sites, which could lead to drastically amplify ultrasonic cavitation effect by responding to the mild LEUS (1 MHz, ≤1.0 W cm −2 ). Significant killing effect against cancer cells is observed, when cells are treated by synergetic combination of mild LEUS and the nanoagents with closed-end cavities, showing distinct dose dependency on the nanoagents and irradiation intensity. Nevertheless, the killing effect is disappeared when the closed-end cavities are destructed. Moreover, no obvious cytotoxicity is observed when either the nanoagents or the LEUS is applied alone. The research may open up application opportunities of mild low-energy ultrasound for cancer therapy.
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titleSynergistic cytotoxicity of low-energy ultrasound and innovative mesoporous silica-based sensitive nanoagents
descriptionLow-energy ultrasound (LEUS) shows distinct potential as a safe therapeutic strategy for cancer treatment. Herein, mesoporous silica nanoparticles with closed-end cavities as sensitive nanoagents are prepared for effective cancer cell killing, when synergistically combined with mild LEUS (1 MHz, ≤1.0 W cm −2 ). The closed-end cavities can entrap gas bubbles, and provide a large number of cavitation nucleation sites, which could lead to drastically amplify ultrasonic cavitation effect by responding to the mild LEUS (1 MHz, ≤1.0 W cm −2 ). Significant killing effect against cancer cells is observed, when cells are treated by synergetic combination of mild LEUS and the nanoagents with closed-end cavities, showing distinct dose dependency on the nanoagents and irradiation intensity. Nevertheless, the killing effect is disappeared when the closed-end cavities are destructed. Moreover, no obvious cytotoxicity is observed when either the nanoagents or the LEUS is applied alone. The research may open up application opportunities of mild low-energy ultrasound for cancer therapy.
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abstractLow-energy ultrasound (LEUS) shows distinct potential as a safe therapeutic strategy for cancer treatment. Herein, mesoporous silica nanoparticles with closed-end cavities as sensitive nanoagents are prepared for effective cancer cell killing, when synergistically combined with mild LEUS (1 MHz, ≤1.0 W cm −2 ). The closed-end cavities can entrap gas bubbles, and provide a large number of cavitation nucleation sites, which could lead to drastically amplify ultrasonic cavitation effect by responding to the mild LEUS (1 MHz, ≤1.0 W cm −2 ). Significant killing effect against cancer cells is observed, when cells are treated by synergetic combination of mild LEUS and the nanoagents with closed-end cavities, showing distinct dose dependency on the nanoagents and irradiation intensity. Nevertheless, the killing effect is disappeared when the closed-end cavities are destructed. Moreover, no obvious cytotoxicity is observed when either the nanoagents or the LEUS is applied alone. The research may open up application opportunities of mild low-energy ultrasound for cancer therapy.
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pubSpringer US
doi10.1007/s10853-014-8073-y
pages3665-3673
date2014-05