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Alginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation

A composite collagen hydrogel containing protein encapsulated alginate microspheres was developed for ocular applications. Bovine serum albumin (BSA) served as a drug model. The composite hydrogel retained optical clarity and mechanical robustness of control hydrogels without microspheres. A sustain... Full description

Journal Title: Journal of Materials Science: Materials in Medicine 2008, Vol.19(11), pp.3365-3371
Main Author: Liu, Wenguang
Other Authors: Griffith, May , LI, Fengfu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0957-4530 ; E-ISSN: 1573-4838 ; DOI: 10.1007/s10856-008-3486-2
Link: http://dx.doi.org/10.1007/s10856-008-3486-2
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recordid: springer_jour10.1007/s10856-008-3486-2
title: Alginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation
format: Article
creator:
  • Liu, Wenguang
  • Griffith, May
  • LI, Fengfu
subjects:
  • Alginates–Chemistry
  • Animals–Chemistry
  • Biocompatible Materials–Chemistry
  • Cattle–Cytology
  • Cell Line, Transformed–Methods
  • Collagen–Chemistry
  • Cornea–Chemistry
  • Drug Delivery Systems–Chemistry
  • Elasticity–Chemistry
  • Eye–Chemistry
  • Glucuronic Acid–Chemistry
  • Hexuronic Acids–Chemistry
  • Humans–Chemistry
  • Hydrogel–Chemistry
  • Materials Testing–Chemistry
  • Microspheres–Chemistry
  • Particle Size–Chemistry
  • Serum Albumin, Bovine–Chemistry
  • Swine–Chemistry
  • Tensile Strength
ispartof: Journal of Materials Science: Materials in Medicine, 2008, Vol.19(11), pp.3365-3371
description: A composite collagen hydrogel containing protein encapsulated alginate microspheres was developed for ocular applications. Bovine serum albumin (BSA) served as a drug model. The composite hydrogel retained optical clarity and mechanical robustness of control hydrogels without microspheres. A sustained release of BSA was achieved during an 11-day period in neutral phosphate buffer. The composite hydrogel supported human corneal epithelial cell growth and had adequate mechanical strength and excellent optical clarity for possible use as therapeutic lens for drug delivery and/or use as corneal substitute for transplantation into patients who have corneal diseases.
language: eng
source:
identifier: ISSN: 0957-4530 ; E-ISSN: 1573-4838 ; DOI: 10.1007/s10856-008-3486-2
fulltext: fulltext
issn:
  • 1573-4838
  • 15734838
  • 0957-4530
  • 09574530
url: Link


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titleAlginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation
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descriptionA composite collagen hydrogel containing protein encapsulated alginate microspheres was developed for ocular applications. Bovine serum albumin (BSA) served as a drug model. The composite hydrogel retained optical clarity and mechanical robustness of control hydrogels without microspheres. A sustained release of BSA was achieved during an 11-day period in neutral phosphate buffer. The composite hydrogel supported human corneal epithelial cell growth and had adequate mechanical strength and excellent optical clarity for possible use as therapeutic lens for drug delivery and/or use as corneal substitute for transplantation into patients who have corneal diseases.
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subjectAlginates–Chemistry ; Animals–Chemistry ; Biocompatible Materials–Chemistry ; Cattle–Cytology ; Cell Line, Transformed–Methods ; Collagen–Chemistry ; Cornea–Chemistry ; Drug Delivery Systems–Chemistry ; Elasticity–Chemistry ; Eye–Chemistry ; Glucuronic Acid–Chemistry ; Hexuronic Acids–Chemistry ; Humans–Chemistry ; Hydrogel–Chemistry ; Materials Testing–Chemistry ; Microspheres–Chemistry ; Particle Size–Chemistry ; Serum Albumin, Bovine–Chemistry ; Swine–Chemistry ; Tensile Strength;
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titleAlginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation
descriptionA composite collagen hydrogel containing protein encapsulated alginate microspheres was developed for ocular applications. Bovine serum albumin (BSA) served as a drug model. The composite hydrogel retained optical clarity and mechanical robustness of control hydrogels without microspheres. A sustained release of BSA was achieved during an 11-day period in neutral phosphate buffer. The composite hydrogel supported human corneal epithelial cell growth and had adequate mechanical strength and excellent optical clarity for possible use as therapeutic lens for drug delivery and/or use as corneal substitute for transplantation into patients who have corneal diseases.
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abstractA composite collagen hydrogel containing protein encapsulated alginate microspheres was developed for ocular applications. Bovine serum albumin (BSA) served as a drug model. The composite hydrogel retained optical clarity and mechanical robustness of control hydrogels without microspheres. A sustained release of BSA was achieved during an 11-day period in neutral phosphate buffer. The composite hydrogel supported human corneal epithelial cell growth and had adequate mechanical strength and excellent optical clarity for possible use as therapeutic lens for drug delivery and/or use as corneal substitute for transplantation into patients who have corneal diseases.
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