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Photoinduced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on silicone hydrogels for reducing protein adsorption

The biomimetic synthetic methacrylate monomer containing a phosphorylcholine group, 2-methacryloyloxyethyl phosphorylcholine (MPC), has been widely used to improve the surface property of biomaterials. In the current report, both hydrophilic and antifouling surfaces were prepared on silicone hydroge... Full description

Journal Title: Journal of Materials Science: Materials in Medicine 2011, Vol.22(12), pp.2651-2657
Main Author: Wang, Jing
Other Authors: Liu, Fang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0957-4530 ; E-ISSN: 1573-4838 ; DOI: 10.1007/s10856-011-4452-y
Link: http://dx.doi.org/10.1007/s10856-011-4452-y
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recordid: springer_jour10.1007/s10856-011-4452-y
title: Photoinduced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on silicone hydrogels for reducing protein adsorption
format: Article
creator:
  • Wang, Jing
  • Liu, Fang
subjects:
  • Biological Products -- Mechanical Properties
  • Biological Products -- Chemical Properties
  • Biomimetics -- Mechanical Properties
  • Biomimetics -- Chemical Properties
  • Adsorption -- Mechanical Properties
  • Adsorption -- Chemical Properties
  • Polymerization -- Mechanical Properties
  • Polymerization -- Chemical Properties
  • Methyl Methacrylate -- Mechanical Properties
  • Methyl Methacrylate -- Chemical Properties
  • Permeability -- Mechanical Properties
  • Permeability -- Chemical Properties
  • Silicones -- Mechanical Properties
  • Silicones -- Chemical Properties
ispartof: Journal of Materials Science: Materials in Medicine, 2011, Vol.22(12), pp.2651-2657
description: The biomimetic synthetic methacrylate monomer containing a phosphorylcholine group, 2-methacryloyloxyethyl phosphorylcholine (MPC), has been widely used to improve the surface property of biomaterials. In the current report, both hydrophilic and antifouling surfaces were prepared on silicone hydrogels with MPC grafted by UV-induced free radical polymerization. The MPC-grafted silicone hydrogels were characterized by graft yield and static water contact angle (SCA) measurements. According to the results, the graft yield reached a maximum at 5 min of UV exposure time and 8 wt% MPC concentration. The modified silicone hydrogels possessed hydrophilic surfaces with the lowest water contact angle of 20º. The oxygen permeability of the MPC-grafted silicone hydrogels was as high as the unmodified silicone hydrogel. The mechanical property of silicone hydrogels was maintained at about 95% of the tensile strength and elastic modulus after the MPC grafting. The results of the in vitro single protein adsorption on the MPC-grafted silicone hydrogels were in agreement with the SCA measurements. The smaller the water contact angle, the greater was the protein repelling ability. The MPC-grafted silicone hydrogel is expected to be a novel biomaterial which possesses excellent surface hydrophilicity, antifouling property, oxygen permeability and mechanical property.
language: eng
source:
identifier: ISSN: 0957-4530 ; E-ISSN: 1573-4838 ; DOI: 10.1007/s10856-011-4452-y
fulltext: fulltext
issn:
  • 1573-4838
  • 15734838
  • 0957-4530
  • 09574530
url: Link


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titlePhotoinduced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on silicone hydrogels for reducing protein adsorption
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descriptionThe biomimetic synthetic methacrylate monomer containing a phosphorylcholine group, 2-methacryloyloxyethyl phosphorylcholine (MPC), has been widely used to improve the surface property of biomaterials. In the current report, both hydrophilic and antifouling surfaces were prepared on silicone hydrogels with MPC grafted by UV-induced free radical polymerization. The MPC-grafted silicone hydrogels were characterized by graft yield and static water contact angle (SCA) measurements. According to the results, the graft yield reached a maximum at 5 min of UV exposure time and 8 wt% MPC concentration. The modified silicone hydrogels possessed hydrophilic surfaces with the lowest water contact angle of 20º. The oxygen permeability of the MPC-grafted silicone hydrogels was as high as the unmodified silicone hydrogel. The mechanical property of silicone hydrogels was maintained at about 95% of the tensile strength and elastic modulus after the MPC grafting. The results of the in vitro single protein adsorption on the MPC-grafted silicone hydrogels were in agreement with the SCA measurements. The smaller the water contact angle, the greater was the protein repelling ability. The MPC-grafted silicone hydrogel is expected to be a novel biomaterial which possesses excellent surface hydrophilicity, antifouling property, oxygen permeability and mechanical property.
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subjectBiological Products -- Mechanical Properties ; Biological Products -- Chemical Properties ; Biomimetics -- Mechanical Properties ; Biomimetics -- Chemical Properties ; Adsorption -- Mechanical Properties ; Adsorption -- Chemical Properties ; Polymerization -- Mechanical Properties ; Polymerization -- Chemical Properties ; Methyl Methacrylate -- Mechanical Properties ; Methyl Methacrylate -- Chemical Properties ; Permeability -- Mechanical Properties ; Permeability -- Chemical Properties ; Silicones -- Mechanical Properties ; Silicones -- Chemical Properties;
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titlePhotoinduced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on silicone hydrogels for reducing protein adsorption
descriptionThe biomimetic synthetic methacrylate monomer containing a phosphorylcholine group, 2-methacryloyloxyethyl phosphorylcholine (MPC), has been widely used to improve the surface property of biomaterials. In the current report, both hydrophilic and antifouling surfaces were prepared on silicone hydrogels with MPC grafted by UV-induced free radical polymerization. The MPC-grafted silicone hydrogels were characterized by graft yield and static water contact angle (SCA) measurements. According to the results, the graft yield reached a maximum at 5 min of UV exposure time and 8 wt% MPC concentration. The modified silicone hydrogels possessed hydrophilic surfaces with the lowest water contact angle of 20º. The oxygen permeability of the MPC-grafted silicone hydrogels was as high as the unmodified silicone hydrogel. The mechanical property of silicone hydrogels was maintained at about 95% of the tensile strength and elastic modulus after the MPC grafting. The results of the in vitro single protein adsorption on the MPC-grafted silicone hydrogels were in agreement with the SCA measurements. The smaller the water contact angle, the greater was the protein repelling ability. The MPC-grafted silicone hydrogel is expected to be a novel biomaterial which possesses excellent surface hydrophilicity, antifouling property, oxygen permeability and mechanical property.
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abstractThe biomimetic synthetic methacrylate monomer containing a phosphorylcholine group, 2-methacryloyloxyethyl phosphorylcholine (MPC), has been widely used to improve the surface property of biomaterials. In the current report, both hydrophilic and antifouling surfaces were prepared on silicone hydrogels with MPC grafted by UV-induced free radical polymerization. The MPC-grafted silicone hydrogels were characterized by graft yield and static water contact angle (SCA) measurements. According to the results, the graft yield reached a maximum at 5 min of UV exposure time and 8 wt% MPC concentration. The modified silicone hydrogels possessed hydrophilic surfaces with the lowest water contact angle of 20º. The oxygen permeability of the MPC-grafted silicone hydrogels was as high as the unmodified silicone hydrogel. The mechanical property of silicone hydrogels was maintained at about 95% of the tensile strength and elastic modulus after the MPC grafting. The results of the in vitro single protein adsorption on the MPC-grafted silicone hydrogels were in agreement with the SCA measurements. The smaller the water contact angle, the greater was the protein repelling ability. The MPC-grafted silicone hydrogel is expected to be a novel biomaterial which possesses excellent surface hydrophilicity, antifouling property, oxygen permeability and mechanical property.
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doi10.1007/s10856-011-4452-y
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date2011-12