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Preparation, characterization and in vitro release properties of morphine-loaded PLLA-PEG-PLLA microparticles via solution enhanced dispersion by supercritical fluids

Morphine-loaded poly( l -lactide)-poly(ethylene glycol)-poly( l -lactide) (PLLA-PEG-PLLA) microparticles were prepared using solution enhanced dispersion by supercritical CO 2 (SEDS). The effects of process variables on the morphology, particles size, drug loading (DL), encapsulation efficiency and... Full description

Journal Title: Journal of Materials Science: Materials in Medicine 2013, Vol.24(7), pp.1693-1705
Main Author: Chen, Fu
Other Authors: Yin, Guangfu , Liao, Xiaoming , Yang, Yi , Huang, Zhongbing , Gu, Jianwen , Yao, Yadong , Chen, Xianchun , Gao, Hu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0957-4530 ; E-ISSN: 1573-4838 ; DOI: 10.1007/s10856-013-4926-1
Link: http://dx.doi.org/10.1007/s10856-013-4926-1
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recordid: springer_jour10.1007/s10856-013-4926-1
title: Preparation, characterization and in vitro release properties of morphine-loaded PLLA-PEG-PLLA microparticles via solution enhanced dispersion by supercritical fluids
format: Article
creator:
  • Chen, Fu
  • Yin, Guangfu
  • Liao, Xiaoming
  • Yang, Yi
  • Huang, Zhongbing
  • Gu, Jianwen
  • Yao, Yadong
  • Chen, Xianchun
  • Gao, Hu
subjects:
  • Morphine
  • Microparticles
  • Polylactic Acid
  • Carbon Dioxide
  • Drugs
  • Controlled Release
  • Encapsulation
  • Tissue Engineering
ispartof: Journal of Materials Science: Materials in Medicine, 2013, Vol.24(7), pp.1693-1705
description: Morphine-loaded poly( l -lactide)-poly(ethylene glycol)-poly( l -lactide) (PLLA-PEG-PLLA) microparticles were prepared using solution enhanced dispersion by supercritical CO 2 (SEDS). The effects of process variables on the morphology, particles size, drug loading (DL), encapsulation efficiency and release properties of the microparticles were investigated. All particles showed spherical or ellipsoidal shape with the mean diameter of 2.04–5.73 μm. The highest DL of 17.92 % was obtained when the dosage ratio of morphine to PLLA-PEG-PLLA reached 1:5, and the encapsulation efficiency can be as high as 87.31 % under appropriate conditions. Morphine-loaded PLLA-PEG-PLLA microparticles displayed short-term release with burst release followed by sustained release within days or long-term release lasted for weeks. The degradation test of the particles showed that the degradation rate of PLLA-PEG-PLLA microparticles was faster than that of PLLA microparticles. The results collectively suggest that PLLA-PEG-PLLA can be a promising candidate polymer for the controlled release system.
language: eng
source:
identifier: ISSN: 0957-4530 ; E-ISSN: 1573-4838 ; DOI: 10.1007/s10856-013-4926-1
fulltext: fulltext
issn:
  • 1573-4838
  • 15734838
  • 0957-4530
  • 09574530
url: Link


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titlePreparation, characterization and in vitro release properties of morphine-loaded PLLA-PEG-PLLA microparticles via solution enhanced dispersion by supercritical fluids
creatorChen, Fu ; Yin, Guangfu ; Liao, Xiaoming ; Yang, Yi ; Huang, Zhongbing ; Gu, Jianwen ; Yao, Yadong ; Chen, Xianchun ; Gao, Hu
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descriptionMorphine-loaded poly( l -lactide)-poly(ethylene glycol)-poly( l -lactide) (PLLA-PEG-PLLA) microparticles were prepared using solution enhanced dispersion by supercritical CO 2 (SEDS). The effects of process variables on the morphology, particles size, drug loading (DL), encapsulation efficiency and release properties of the microparticles were investigated. All particles showed spherical or ellipsoidal shape with the mean diameter of 2.04–5.73 μm. The highest DL of 17.92 % was obtained when the dosage ratio of morphine to PLLA-PEG-PLLA reached 1:5, and the encapsulation efficiency can be as high as 87.31 % under appropriate conditions. Morphine-loaded PLLA-PEG-PLLA microparticles displayed short-term release with burst release followed by sustained release within days or long-term release lasted for weeks. The degradation test of the particles showed that the degradation rate of PLLA-PEG-PLLA microparticles was faster than that of PLLA microparticles. The results collectively suggest that PLLA-PEG-PLLA can be a promising candidate polymer for the controlled release system.
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titlePreparation, characterization and in vitro release properties of morphine-loaded PLLA-PEG-PLLA microparticles via solution enhanced dispersion by supercritical fluids
descriptionMorphine-loaded poly( l -lactide)-poly(ethylene glycol)-poly( l -lactide) (PLLA-PEG-PLLA) microparticles were prepared using solution enhanced dispersion by supercritical CO 2 (SEDS). The effects of process variables on the morphology, particles size, drug loading (DL), encapsulation efficiency and release properties of the microparticles were investigated. All particles showed spherical or ellipsoidal shape with the mean diameter of 2.04–5.73 μm. The highest DL of 17.92 % was obtained when the dosage ratio of morphine to PLLA-PEG-PLLA reached 1:5, and the encapsulation efficiency can be as high as 87.31 % under appropriate conditions. Morphine-loaded PLLA-PEG-PLLA microparticles displayed short-term release with burst release followed by sustained release within days or long-term release lasted for weeks. The degradation test of the particles showed that the degradation rate of PLLA-PEG-PLLA microparticles was faster than that of PLLA microparticles. The results collectively suggest that PLLA-PEG-PLLA can be a promising candidate polymer for the controlled release system.
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titlePreparation, characterization and in vitro release properties of morphine-loaded PLLA-PEG-PLLA microparticles via solution enhanced dispersion by supercritical fluids
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abstractMorphine-loaded poly( l -lactide)-poly(ethylene glycol)-poly( l -lactide) (PLLA-PEG-PLLA) microparticles were prepared using solution enhanced dispersion by supercritical CO 2 (SEDS). The effects of process variables on the morphology, particles size, drug loading (DL), encapsulation efficiency and release properties of the microparticles were investigated. All particles showed spherical or ellipsoidal shape with the mean diameter of 2.04–5.73 μm. The highest DL of 17.92 % was obtained when the dosage ratio of morphine to PLLA-PEG-PLLA reached 1:5, and the encapsulation efficiency can be as high as 87.31 % under appropriate conditions. Morphine-loaded PLLA-PEG-PLLA microparticles displayed short-term release with burst release followed by sustained release within days or long-term release lasted for weeks. The degradation test of the particles showed that the degradation rate of PLLA-PEG-PLLA microparticles was faster than that of PLLA microparticles. The results collectively suggest that PLLA-PEG-PLLA can be a promising candidate polymer for the controlled release system.
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pubSpringer US
doi10.1007/s10856-013-4926-1
pages1693-1705
date2013-07