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FFAs and adipokine-mediated regulation of hsa-miR-143 expression in human adipocytes

Accumulating evidence suggests that microRNAs (miRNAs) play an important role in regulating the pathways in adipose tissue that control processes such as adipogenesis, insulin resistance, and inflammation. MiR-143 is a well-characterized miRNA involved in adipogenesis and may be involved in regulati... Full description

Journal Title: Molecular Biology Reports 2013, Vol.40(10), pp.5669-5675
Main Author: Zhu, Lingling
Other Authors: Shi, Chunmei , Ji, Chenbo , Xu, Guangfeng , Chen, Ling , Yang, Lei , Fu, Ziyi , Cui, Xianwei , Lu, Yibing , Guo, Xirong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0301-4851 ; E-ISSN: 1573-4978 ; DOI: 10.1007/s11033-013-2668-2
Link: http://dx.doi.org/10.1007/s11033-013-2668-2
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recordid: springer_jour10.1007/s11033-013-2668-2
title: FFAs and adipokine-mediated regulation of hsa-miR-143 expression in human adipocytes
format: Article
creator:
  • Zhu, Lingling
  • Shi, Chunmei
  • Ji, Chenbo
  • Xu, Guangfeng
  • Chen, Ling
  • Yang, Lei
  • Fu, Ziyi
  • Cui, Xianwei
  • Lu, Yibing
  • Guo, Xirong
subjects:
  • Hsa-miR-143
  • Adipocyte
  • Free fatty acids
  • Tumor necrosis factor-α
  • Interleukin-6
  • Resistin
  • Leptin
ispartof: Molecular Biology Reports, 2013, Vol.40(10), pp.5669-5675
description: Accumulating evidence suggests that microRNAs (miRNAs) play an important role in regulating the pathways in adipose tissue that control processes such as adipogenesis, insulin resistance, and inflammation. MiR-143 is a well-characterized miRNA involved in adipogenesis and may be involved in regulating insulin resistance. Free fatty acids (FFAs) and adipokines, such as tumor necrosis factor-α (TNF-α), leptin, resistin, and interleukin-6 (IL-6), have already been identified as main regulators of obesity and insulin sensitivity. Therefore, we studied the effects of these inflammatory cytokines on the expression of miR-143. FFAs, resistin, and leptin downregulated miR-143 expression in human adipocytes, whereas TNF-α and IL-6 had little effect on miR-143 expression. These results suggest that the expression of miR-143 is affected by a variety of factors that are related to insulin sensitivity. Therefore, miR-143 may be an important mediator in the development of obesity-related insulin resistance.
language: eng
source:
identifier: ISSN: 0301-4851 ; E-ISSN: 1573-4978 ; DOI: 10.1007/s11033-013-2668-2
fulltext: fulltext
issn:
  • 1573-4978
  • 15734978
  • 0301-4851
  • 03014851
url: Link


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titleFFAs and adipokine-mediated regulation of hsa-miR-143 expression in human adipocytes
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subjectHsa-miR-143 ; Adipocyte ; Free fatty acids ; Tumor necrosis factor-α ; Interleukin-6 ; Resistin ; Leptin
descriptionAccumulating evidence suggests that microRNAs (miRNAs) play an important role in regulating the pathways in adipose tissue that control processes such as adipogenesis, insulin resistance, and inflammation. MiR-143 is a well-characterized miRNA involved in adipogenesis and may be involved in regulating insulin resistance. Free fatty acids (FFAs) and adipokines, such as tumor necrosis factor-α (TNF-α), leptin, resistin, and interleukin-6 (IL-6), have already been identified as main regulators of obesity and insulin sensitivity. Therefore, we studied the effects of these inflammatory cytokines on the expression of miR-143. FFAs, resistin, and leptin downregulated miR-143 expression in human adipocytes, whereas TNF-α and IL-6 had little effect on miR-143 expression. These results suggest that the expression of miR-143 is affected by a variety of factors that are related to insulin sensitivity. Therefore, miR-143 may be an important mediator in the development of obesity-related insulin resistance.
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titleFFAs and adipokine-mediated regulation of hsa-miR-143 expression in human adipocytes
authorZhu, Lingling ; Shi, Chunmei ; Ji, Chenbo ; Xu, Guangfeng ; Chen, Ling ; Yang, Lei ; Fu, Ziyi ; Cui, Xianwei ; Lu, Yibing ; Guo, Xirong
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abstractAccumulating evidence suggests that microRNAs (miRNAs) play an important role in regulating the pathways in adipose tissue that control processes such as adipogenesis, insulin resistance, and inflammation. MiR-143 is a well-characterized miRNA involved in adipogenesis and may be involved in regulating insulin resistance. Free fatty acids (FFAs) and adipokines, such as tumor necrosis factor-α (TNF-α), leptin, resistin, and interleukin-6 (IL-6), have already been identified as main regulators of obesity and insulin sensitivity. Therefore, we studied the effects of these inflammatory cytokines on the expression of miR-143. FFAs, resistin, and leptin downregulated miR-143 expression in human adipocytes, whereas TNF-α and IL-6 had little effect on miR-143 expression. These results suggest that the expression of miR-143 is affected by a variety of factors that are related to insulin sensitivity. Therefore, miR-143 may be an important mediator in the development of obesity-related insulin resistance.
copDordrecht
pubSpringer Netherlands
doi10.1007/s11033-013-2668-2
pages5669-5675
date2013-10