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An evaluation of anti-tumor effect and toxicity of PEGylated ursolic acid liposomes

Byline: Qianqian Wang (1), Tingting Zhao (1), Yanping Liu (1), Shanshan Xing (1), Lei Li (1), Dawei Gao (1) Keywords: PEGylated liposome; Ursolic acid; Anti-tumor activity; Tumor-bearing mouse; Cytotoxicity; Drug delivery Abstract: Abstract Therapy of solid tumors mediated by nano-drug delivery has... Full description

Journal Title: Journal of Nanoparticle Research 2016, Vol.18(2), pp.1-13
Main Author: Wang, Qianqian
Other Authors: Zhao, Tingting , Liu, Yanping , Xing, Shanshan , Li, Lei , Gao, Dawei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1388-0764 ; E-ISSN: 1572-896X ; DOI: 10.1007/s11051-016-3339-8
Link: http://dx.doi.org/10.1007/s11051-016-3339-8
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recordid: springer_jour10.1007/s11051-016-3339-8
title: An evaluation of anti-tumor effect and toxicity of PEGylated ursolic acid liposomes
format: Article
creator:
  • Wang, Qianqian
  • Zhao, Tingting
  • Liu, Yanping
  • Xing, Shanshan
  • Li, Lei
  • Gao, Dawei
subjects:
  • PEGylated liposome
  • Ursolic acid
  • Anti-tumor activity
  • Tumor-bearing mouse
  • Cytotoxicity
  • Drug delivery
ispartof: Journal of Nanoparticle Research, 2016, Vol.18(2), pp.1-13
description: Byline: Qianqian Wang (1), Tingting Zhao (1), Yanping Liu (1), Shanshan Xing (1), Lei Li (1), Dawei Gao (1) Keywords: PEGylated liposome; Ursolic acid; Anti-tumor activity; Tumor-bearing mouse; Cytotoxicity; Drug delivery Abstract: Abstract Therapy of solid tumors mediated by nano-drug delivery has attracted considerable interest. In our previous study, ursolic acid (UA) was successfully encapsulated into PEGylated liposomes. The study aimed to evaluate the tumor inhibition effect and cytotoxicity of the PEGylated UA liposomes by U14 cervical carcinoma-bearing mice. The liposomes were spherical particles with mean particle diameters of 127.2 nm. The tumor inhibition rate of PEGylated UA liposomes was 53.60 % on U14 cervical carcinoma-bearing mice, which was greater than those of the UA solution (18.25 %) and traditional UA liposome groups (40.75 %). The tumor cells apoptosis rate of PEGylated UA liposomes was 25.81 %, which was significantly higher than that of the traditional UA liposomes (13.37 %). Moreover, the kidney and liver did not emerge the pathological changes in UA therapeutic mice by histopathological analysis, while there were significant differences on tumor tissues among three UA formulation groups. The PEGylated UA liposomes exhibited higher anti-tumor activity and lower cytotoxicity, and the main reason was that the coating PEG layer improved UA liposome properties, such as enhancing the stability of liposomes, promoting the effect of slow release, and prolonging the time of blood circulation. This may shed light on the development of PEGylated nano-vehicles. Graphical Abstract Author Affiliation: (1) Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao, 066004, China Article History: Registration Date: 14/01/2016 Received Date: 08/12/2015 Accepted Date: 14/01/2016 Online Date: 08/02/2016
language: eng
source:
identifier: ISSN: 1388-0764 ; E-ISSN: 1572-896X ; DOI: 10.1007/s11051-016-3339-8
fulltext: fulltext
issn:
  • 1572-896X
  • 1572896X
  • 1388-0764
  • 13880764
url: Link


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titleAn evaluation of anti-tumor effect and toxicity of PEGylated ursolic acid liposomes
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descriptionByline: Qianqian Wang (1), Tingting Zhao (1), Yanping Liu (1), Shanshan Xing (1), Lei Li (1), Dawei Gao (1) Keywords: PEGylated liposome; Ursolic acid; Anti-tumor activity; Tumor-bearing mouse; Cytotoxicity; Drug delivery Abstract: Abstract Therapy of solid tumors mediated by nano-drug delivery has attracted considerable interest. In our previous study, ursolic acid (UA) was successfully encapsulated into PEGylated liposomes. The study aimed to evaluate the tumor inhibition effect and cytotoxicity of the PEGylated UA liposomes by U14 cervical carcinoma-bearing mice. The liposomes were spherical particles with mean particle diameters of 127.2 nm. The tumor inhibition rate of PEGylated UA liposomes was 53.60 % on U14 cervical carcinoma-bearing mice, which was greater than those of the UA solution (18.25 %) and traditional UA liposome groups (40.75 %). The tumor cells apoptosis rate of PEGylated UA liposomes was 25.81 %, which was significantly higher than that of the traditional UA liposomes (13.37 %). Moreover, the kidney and liver did not emerge the pathological changes in UA therapeutic mice by histopathological analysis, while there were significant differences on tumor tissues among three UA formulation groups. The PEGylated UA liposomes exhibited higher anti-tumor activity and lower cytotoxicity, and the main reason was that the coating PEG layer improved UA liposome properties, such as enhancing the stability of liposomes, promoting the effect of slow release, and prolonging the time of blood circulation. This may shed light on the development of PEGylated nano-vehicles. Graphical Abstract Author Affiliation: (1) Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao, 066004, China Article History: Registration Date: 14/01/2016 Received Date: 08/12/2015 Accepted Date: 14/01/2016 Online Date: 08/02/2016
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