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The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma

Forkhead box protein 3 (Foxp3) is known as a specific marker for regulatory T cells which contribute to immunosuppression in tumor microenvironment. However, existing studies regarding clinical significance of Foxp3+ tumor-infiltrating lymphocytes (TILs) in glioblastoma (GBM) remained discrepant. In... Full description

Journal Title: Journal of Neuro-Oncology 2014, Vol.116(2), pp.251-259
Main Author: Yue, Qi
Other Authors: Zhang, Xin , Ye, Hong-xing , Wang, Yin , Du, Zun-guo , Yao, Yu , Mao, Ying
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Springer Science & Business Media B.V.
ID: ISSN: 0167-594X ; E-ISSN: 1573-7373 ; DOI: 10.1007/s11060-013-1314-0
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recordid: springer_jour10.1007/s11060-013-1314-0
title: The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma
format: Article
creator:
  • Yue, Qi
  • Zhang, Xin
  • Ye, Hong-xing
  • Wang, Yin
  • Du, Zun-guo
  • Yao, Yu
  • Mao, Ying
subjects:
  • Foxp3
  • Tumor-infiltrating lymphocyte
  • Regulatory T cell
  • Glioblastoma
  • Prognosis
ispartof: Journal of Neuro-Oncology, 2014, Vol.116(2), pp.251-259
description: Forkhead box protein 3 (Foxp3) is known as a specific marker for regulatory T cells which contribute to immunosuppression in tumor microenvironment. However, existing studies regarding clinical significance of Foxp3+ tumor-infiltrating lymphocytes (TILs) in glioblastoma (GBM) remained discrepant. In this study, we aimed to explore whether this subtype of TILs correlated with prognosis in patients with GBM. Foxp3+ TILs as well as CD8+ ones were detected by immunohistochemistry on paraffin-embedded tumor samples from 62 patients. Staining for p53, MGMT and Ki-67 were also performed. The correlation of TIL subtypes with clinicopathologic features were analyzed. Progression-free survival (PFS) and overall survival (OS) were estimated by Kaplan–Meier method and compared using log-rank test. Independent prognostic factors for PFS and OS were determined through univariate and multivariate analysis. Significant correlation was found between Foxp3 and CD8 expression ( P  = 0.003), but not between TIL subtypes and clinicopathologic characteristics. Patients with higher density of Foxp3+ TILs showed relatively shorter PFS ( P  
language: eng
source: Springer Science & Business Media B.V.
identifier: ISSN: 0167-594X ; E-ISSN: 1573-7373 ; DOI: 10.1007/s11060-013-1314-0
fulltext: fulltext_linktorsrc
issn:
  • 1573-7373
  • 15737373
  • 0167-594X
  • 0167594X
url: Link


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titleThe prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma
creatorYue, Qi ; Zhang, Xin ; Ye, Hong-xing ; Wang, Yin ; Du, Zun-guo ; Yao, Yu ; Mao, Ying
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descriptionForkhead box protein 3 (Foxp3) is known as a specific marker for regulatory T cells which contribute to immunosuppression in tumor microenvironment. However, existing studies regarding clinical significance of Foxp3+ tumor-infiltrating lymphocytes (TILs) in glioblastoma (GBM) remained discrepant. In this study, we aimed to explore whether this subtype of TILs correlated with prognosis in patients with GBM. Foxp3+ TILs as well as CD8+ ones were detected by immunohistochemistry on paraffin-embedded tumor samples from 62 patients. Staining for p53, MGMT and Ki-67 were also performed. The correlation of TIL subtypes with clinicopathologic features were analyzed. Progression-free survival (PFS) and overall survival (OS) were estimated by Kaplan–Meier method and compared using log-rank test. Independent prognostic factors for PFS and OS were determined through univariate and multivariate analysis. Significant correlation was found between Foxp3 and CD8 expression ( P  = 0.003), but not between TIL subtypes and clinicopathologic characteristics. Patients with higher density of Foxp3+ TILs showed relatively shorter PFS ( P  < 0.001) and OS ( P  = 0.003) whereas patients with higher density of CD8+ TILs obtained no significant differences in survival. Survival analysis based on molecular classifications further clarified these predictive values. Univariate and multivariate analysis revealed that frequency of Foxp3+ TILs was probably associated with both PFS ( P  = 0.002) and OS ( P  = 0.003). In conclusion, the results suggest that Foxp3 positive infiltrates could provide an independent predictive factor in GBM.
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abstractForkhead box protein 3 (Foxp3) is known as a specific marker for regulatory T cells which contribute to immunosuppression in tumor microenvironment. However, existing studies regarding clinical significance of Foxp3+ tumor-infiltrating lymphocytes (TILs) in glioblastoma (GBM) remained discrepant. In this study, we aimed to explore whether this subtype of TILs correlated with prognosis in patients with GBM. Foxp3+ TILs as well as CD8+ ones were detected by immunohistochemistry on paraffin-embedded tumor samples from 62 patients. Staining for p53, MGMT and Ki-67 were also performed. The correlation of TIL subtypes with clinicopathologic features were analyzed. Progression-free survival (PFS) and overall survival (OS) were estimated by Kaplan–Meier method and compared using log-rank test. Independent prognostic factors for PFS and OS were determined through univariate and multivariate analysis. Significant correlation was found between Foxp3 and CD8 expression ( P  = 0.003), but not between TIL subtypes and clinicopathologic characteristics. Patients with higher density of Foxp3+ TILs showed relatively shorter PFS ( P  < 0.001) and OS ( P  = 0.003) whereas patients with higher density of CD8+ TILs obtained no significant differences in survival. Survival analysis based on molecular classifications further clarified these predictive values. Univariate and multivariate analysis revealed that frequency of Foxp3+ TILs was probably associated with both PFS ( P  = 0.002) and OS ( P  = 0.003). In conclusion, the results suggest that Foxp3 positive infiltrates could provide an independent predictive factor in GBM.
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