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Encapsulation of doxorubicin in liposomes containing phosphatidylethanol. Part I: Physicochemical characterization and antitumor activity of liquid crystal liposomes

The effect of phosphatidylethanol (PE) anions on the incorporation of doxorubicin into liquid crystal liposomes consisting of soybean phosphatidylcholine (PC) was studied. Over 90% of the antibiotic are encapsulated in liposomes in the case of a PC/PE = 3: 2 molar ratio, with a doxorubicin content r... Full description

Journal Title: Pharmaceutical Chemistry Journal 2006, Vol.40(1), pp.32-35
Main Author: Zhukova, M.
Other Authors: Kisel’, M. , Kuz’mitskii, B. , Mashkovich, A. , Nasek, V. , Romanenko, O. , Spivak, S.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0091-150X ; E-ISSN: 1573-9031 ; DOI: 10.1007/s11094-006-0052-4
Link: http://dx.doi.org/10.1007/s11094-006-0052-4
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recordid: springer_jour10.1007/s11094-006-0052-4
title: Encapsulation of doxorubicin in liposomes containing phosphatidylethanol. Part I: Physicochemical characterization and antitumor activity of liquid crystal liposomes
format: Article
creator:
  • Zhukova, M.
  • Kisel’, M.
  • Kuz’mitskii, B.
  • Mashkovich, A.
  • Nasek, V.
  • Romanenko, O.
  • Spivak, S.
subjects:
  • Doxorubicin
ispartof: Pharmaceutical Chemistry Journal, 2006, Vol.40(1), pp.32-35
description: The effect of phosphatidylethanol (PE) anions on the incorporation of doxorubicin into liquid crystal liposomes consisting of soybean phosphatidylcholine (PC) was studied. Over 90% of the antibiotic are encapsulated in liposomes in the case of a PC/PE = 3: 2 molar ratio, with a doxorubicin content reaching 130 μg/(mg phospholipids). The Stokes radius of the antibiotic-containing liposomes is estimated at about 160 Å. In terms of the ability to inhibit solid Ehrlich carcinoma in mice, the obtained liposomal doxorubicin preparations are much less effective in comparison to the usual antibiotic.
language: eng
source:
identifier: ISSN: 0091-150X ; E-ISSN: 1573-9031 ; DOI: 10.1007/s11094-006-0052-4
fulltext: fulltext
issn:
  • 1573-9031
  • 15739031
  • 0091-150X
  • 0091150X
url: Link


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titleEncapsulation of doxorubicin in liposomes containing phosphatidylethanol. Part I: Physicochemical characterization and antitumor activity of liquid crystal liposomes
creatorZhukova, M. ; Kisel’, M. ; Kuz’mitskii, B. ; Mashkovich, A. ; Nasek, V. ; Romanenko, O. ; Spivak, S.
ispartofPharmaceutical Chemistry Journal, 2006, Vol.40(1), pp.32-35
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descriptionThe effect of phosphatidylethanol (PE) anions on the incorporation of doxorubicin into liquid crystal liposomes consisting of soybean phosphatidylcholine (PC) was studied. Over 90% of the antibiotic are encapsulated in liposomes in the case of a PC/PE = 3: 2 molar ratio, with a doxorubicin content reaching 130 μg/(mg phospholipids). The Stokes radius of the antibiotic-containing liposomes is estimated at about 160 Å. In terms of the ability to inhibit solid Ehrlich carcinoma in mice, the obtained liposomal doxorubicin preparations are much less effective in comparison to the usual antibiotic.
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titleEncapsulation of doxorubicin in liposomes containing phosphatidylethanol. Part I: Physicochemical characterization and antitumor activity of liquid crystal liposomes
descriptionThe effect of phosphatidylethanol (PE) anions on the incorporation of doxorubicin into liquid crystal liposomes consisting of soybean phosphatidylcholine (PC) was studied. Over 90% of the antibiotic are encapsulated in liposomes in the case of a PC/PE = 3: 2 molar ratio, with a doxorubicin content reaching 130 μg/(mg phospholipids). The Stokes radius of the antibiotic-containing liposomes is estimated at about 160 Å. In terms of the ability to inhibit solid Ehrlich carcinoma in mice, the obtained liposomal doxorubicin preparations are much less effective in comparison to the usual antibiotic.
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titleEncapsulation of doxorubicin in liposomes containing phosphatidylethanol. Part I: Physicochemical characterization and antitumor activity of liquid crystal liposomes
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abstractThe effect of phosphatidylethanol (PE) anions on the incorporation of doxorubicin into liquid crystal liposomes consisting of soybean phosphatidylcholine (PC) was studied. Over 90% of the antibiotic are encapsulated in liposomes in the case of a PC/PE = 3: 2 molar ratio, with a doxorubicin content reaching 130 μg/(mg phospholipids). The Stokes radius of the antibiotic-containing liposomes is estimated at about 160 Å. In terms of the ability to inhibit solid Ehrlich carcinoma in mice, the obtained liposomal doxorubicin preparations are much less effective in comparison to the usual antibiotic.
copNew York
pubKluwer Academic Publishers-Consultants Bureau
doi10.1007/s11094-006-0052-4
pages32-35
date2006-01