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DNA binding and nuclease activity of a water-soluble sulfonated manganese(III) corrole

The interaction of a water-soluble sulfonated Mn(III) corrole Mn(tpfc)(SO 3 Na) 2 [tpfc = 5,10,15-tris(pentafluorophenyl)corrole] with calf thymus DNA (ct-DNA) has been studied by spectroscopic methods, and the nuclease activity of this complex has also been examined by agarose gel electrophoresis.... Full description

Journal Title: Transition Metal Chemistry 2013, Vol.38(3), pp.283-289
Main Author: Huang, Jun-Teng
Other Authors: Wang, Xiang-Li , Zhang, Yang , Mahmood, Mian , Huang, Yan-Yuan , Ying, Xiao , Ji, Liang-Nian , Liu, Hai-Yang
Format: Electronic Article Electronic Article
Language: English
Subjects:
Dna
ID: ISSN: 0340-4285 ; E-ISSN: 1572-901X ; DOI: 10.1007/s11243-013-9689-5
Link: http://dx.doi.org/10.1007/s11243-013-9689-5
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recordid: springer_jour10.1007/s11243-013-9689-5
title: DNA binding and nuclease activity of a water-soluble sulfonated manganese(III) corrole
format: Article
creator:
  • Huang, Jun-Teng
  • Wang, Xiang-Li
  • Zhang, Yang
  • Mahmood, Mian
  • Huang, Yan-Yuan
  • Ying, Xiao
  • Ji, Liang-Nian
  • Liu, Hai-Yang
subjects:
  • Hydrogen Peroxide
  • Genetic Research
  • Dna Binding
  • Bromine Compounds
  • Dna
ispartof: Transition Metal Chemistry, 2013, Vol.38(3), pp.283-289
description: The interaction of a water-soluble sulfonated Mn(III) corrole Mn(tpfc)(SO 3 Na) 2 [tpfc = 5,10,15-tris(pentafluorophenyl)corrole] with calf thymus DNA (ct-DNA) has been studied by spectroscopic methods, and the nuclease activity of this complex has also been examined by agarose gel electrophoresis. Mn(tpfc)(SO 3 Na) 2 exhibits weak aggregation tendency in buffer solution and can bind to ct-DNA via an outside binding mode with a binding constant of 1.25 × 10 4  M −1 . The observed increase in Stern–Volmer quenching constant with increasing temperature indicates that the competition of the manganese corrole and ethidium bromide with ct-DNA is a dynamic process. Moreover, the manganese corrole displays good chemical nuclease activity in the presence of hydrogen peroxide via oxidative cleavage of DNA.
language: eng
source:
identifier: ISSN: 0340-4285 ; E-ISSN: 1572-901X ; DOI: 10.1007/s11243-013-9689-5
fulltext: fulltext
issn:
  • 1572-901X
  • 1572901X
  • 0340-4285
  • 03404285
url: Link


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titleDNA binding and nuclease activity of a water-soluble sulfonated manganese(III) corrole
creatorHuang, Jun-Teng ; Wang, Xiang-Li ; Zhang, Yang ; Mahmood, Mian ; Huang, Yan-Yuan ; Ying, Xiao ; Ji, Liang-Nian ; Liu, Hai-Yang
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descriptionThe interaction of a water-soluble sulfonated Mn(III) corrole Mn(tpfc)(SO 3 Na) 2 [tpfc = 5,10,15-tris(pentafluorophenyl)corrole] with calf thymus DNA (ct-DNA) has been studied by spectroscopic methods, and the nuclease activity of this complex has also been examined by agarose gel electrophoresis. Mn(tpfc)(SO 3 Na) 2 exhibits weak aggregation tendency in buffer solution and can bind to ct-DNA via an outside binding mode with a binding constant of 1.25 × 10 4  M −1 . The observed increase in Stern–Volmer quenching constant with increasing temperature indicates that the competition of the manganese corrole and ethidium bromide with ct-DNA is a dynamic process. Moreover, the manganese corrole displays good chemical nuclease activity in the presence of hydrogen peroxide via oxidative cleavage of DNA.
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titleDNA binding and nuclease activity of a water-soluble sulfonated manganese(III) corrole
descriptionThe interaction of a water-soluble sulfonated Mn(III) corrole Mn(tpfc)(SO 3 Na) 2 [tpfc = 5,10,15-tris(pentafluorophenyl)corrole] with calf thymus DNA (ct-DNA) has been studied by spectroscopic methods, and the nuclease activity of this complex has also been examined by agarose gel electrophoresis. Mn(tpfc)(SO 3 Na) 2 exhibits weak aggregation tendency in buffer solution and can bind to ct-DNA via an outside binding mode with a binding constant of 1.25 × 10 4  M −1 . The observed increase in Stern–Volmer quenching constant with increasing temperature indicates that the competition of the manganese corrole and ethidium bromide with ct-DNA is a dynamic process. Moreover, the manganese corrole displays good chemical nuclease activity in the presence of hydrogen peroxide via oxidative cleavage of DNA.
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titleDNA binding and nuclease activity of a water-soluble sulfonated manganese(III) corrole
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abstractThe interaction of a water-soluble sulfonated Mn(III) corrole Mn(tpfc)(SO 3 Na) 2 [tpfc = 5,10,15-tris(pentafluorophenyl)corrole] with calf thymus DNA (ct-DNA) has been studied by spectroscopic methods, and the nuclease activity of this complex has also been examined by agarose gel electrophoresis. Mn(tpfc)(SO 3 Na) 2 exhibits weak aggregation tendency in buffer solution and can bind to ct-DNA via an outside binding mode with a binding constant of 1.25 × 10 4  M −1 . The observed increase in Stern–Volmer quenching constant with increasing temperature indicates that the competition of the manganese corrole and ethidium bromide with ct-DNA is a dynamic process. Moreover, the manganese corrole displays good chemical nuclease activity in the presence of hydrogen peroxide via oxidative cleavage of DNA.
copDordrecht
pubSpringer Netherlands
doi10.1007/s11243-013-9689-5
pages283-289
date2013-04