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Pathogenesis of neural tube defects: the story beyond methylation or one-carbon unit metabolism

A metabolomic study was performed to investigate the biochemical perturbation of the serum samples from neural tube defects affected pregnant women (cases, n  = 80) and normal pregnant subjects (controls, n  = 95). The serum metabolome was detected using ultra performance liquid chromatography coupl... Full description

Journal Title: Metabolomics 2012, Vol.8(5), pp.919-929
Main Author: Liang, Xiaoping
Other Authors: Wang, Yong , Liang, Qiong , Wang, Yi , Huang, Min , Luo, Guoan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1573-3882 ; E-ISSN: 1573-3890 ; DOI: 10.1007/s11306-011-0387-z
Link: http://dx.doi.org/10.1007/s11306-011-0387-z
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recordid: springer_jour10.1007/s11306-011-0387-z
title: Pathogenesis of neural tube defects: the story beyond methylation or one-carbon unit metabolism
format: Article
creator:
  • Liang, Xiaoping
  • Wang, Yong
  • Liang, Qiong
  • Wang, Yi
  • Huang, Min
  • Luo, Guoan
subjects:
  • Metabolomics
  • Neural tube defects
  • UPLC/TOF–MS
  • Biomarker
ispartof: Metabolomics, 2012, Vol.8(5), pp.919-929
description: A metabolomic study was performed to investigate the biochemical perturbation of the serum samples from neural tube defects affected pregnant women (cases, n  = 80) and normal pregnant subjects (controls, n  = 95). The serum metabolome was detected using ultra performance liquid chromatography coupled to time-of-flight mass spectrometry (UPLC/TOF–MS). The acquired UPLC-MS data were normalized and processed by principal components analysis and orthogonal partial least squares discriminant analysis. The distinctive biochemical differences between the healthy subjects and NTDs-affected pregnant women were displayed by the pattern recognition methods. According to the data, several potential biomarkers were identified: sphingosine-1-phosphate, galactosylsphingosine, 3-oxohexadecanoic acid, fructose-6-phosphate, docosahexaenoic acid, dehydroepiandrosterone sulfate, and linoleic acid were found with decreased concentrations in the cases, and lysophosphatidylcholine and leukotrienes were found with increased concentrations in the cases. On the basis of the relevant literature and pathway databases, the biological significance of the present study is discussed. And the conclusion was obtained that there must be some other metabolic cycles that could contribute to the occurrence of neural tube defects besides the one-carbon unit metabolism.
language: eng
source:
identifier: ISSN: 1573-3882 ; E-ISSN: 1573-3890 ; DOI: 10.1007/s11306-011-0387-z
fulltext: fulltext
issn:
  • 1573-3890
  • 15733890
  • 1573-3882
  • 15733882
url: Link


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titlePathogenesis of neural tube defects: the story beyond methylation or one-carbon unit metabolism
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descriptionA metabolomic study was performed to investigate the biochemical perturbation of the serum samples from neural tube defects affected pregnant women (cases, n  = 80) and normal pregnant subjects (controls, n  = 95). The serum metabolome was detected using ultra performance liquid chromatography coupled to time-of-flight mass spectrometry (UPLC/TOF–MS). The acquired UPLC-MS data were normalized and processed by principal components analysis and orthogonal partial least squares discriminant analysis. The distinctive biochemical differences between the healthy subjects and NTDs-affected pregnant women were displayed by the pattern recognition methods. According to the data, several potential biomarkers were identified: sphingosine-1-phosphate, galactosylsphingosine, 3-oxohexadecanoic acid, fructose-6-phosphate, docosahexaenoic acid, dehydroepiandrosterone sulfate, and linoleic acid were found with decreased concentrations in the cases, and lysophosphatidylcholine and leukotrienes were found with increased concentrations in the cases. On the basis of the relevant literature and pathway databases, the biological significance of the present study is discussed. And the conclusion was obtained that there must be some other metabolic cycles that could contribute to the occurrence of neural tube defects besides the one-carbon unit metabolism.
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abstractA metabolomic study was performed to investigate the biochemical perturbation of the serum samples from neural tube defects affected pregnant women (cases, n  = 80) and normal pregnant subjects (controls, n  = 95). The serum metabolome was detected using ultra performance liquid chromatography coupled to time-of-flight mass spectrometry (UPLC/TOF–MS). The acquired UPLC-MS data were normalized and processed by principal components analysis and orthogonal partial least squares discriminant analysis. The distinctive biochemical differences between the healthy subjects and NTDs-affected pregnant women were displayed by the pattern recognition methods. According to the data, several potential biomarkers were identified: sphingosine-1-phosphate, galactosylsphingosine, 3-oxohexadecanoic acid, fructose-6-phosphate, docosahexaenoic acid, dehydroepiandrosterone sulfate, and linoleic acid were found with decreased concentrations in the cases, and lysophosphatidylcholine and leukotrienes were found with increased concentrations in the cases. On the basis of the relevant literature and pathway databases, the biological significance of the present study is discussed. And the conclusion was obtained that there must be some other metabolic cycles that could contribute to the occurrence of neural tube defects besides the one-carbon unit metabolism.
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