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Plasma metabolomic response to postmenopausal weight loss induced by different diets

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11306-016-1013-x Byline: Elin Chorell (1,4,5), Mats Ryberg (1), Christel Larsson (2), Susanne Sandberg (1), Caroline Mellberg (1), Bernt Lindahl (1), Henrik Antti (3,5... Full description

Journal Title: Metabolomics 2016, Vol.12(5), pp.1-14
Main Author: Chorell, Elin
Other Authors: Ryberg, Mats , Larsson, Christel , Sandberg, Susanne , Mellberg, Caroline , Lindahl, Bernt , Antti, Henrik , Olsson, Tommy
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1573-3882 ; E-ISSN: 1573-3890 ; DOI: 10.1007/s11306-016-1013-x
Link: http://dx.doi.org/10.1007/s11306-016-1013-x
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recordid: springer_jour10.1007/s11306-016-1013-x
title: Plasma metabolomic response to postmenopausal weight loss induced by different diets
format: Article
creator:
  • Chorell, Elin
  • Ryberg, Mats
  • Larsson, Christel
  • Sandberg, Susanne
  • Mellberg, Caroline
  • Lindahl, Bernt
  • Antti, Henrik
  • Olsson, Tommy
subjects:
  • Metabolomics
  • Mass spectrometry
  • Multivariate analysis
  • Paleolithic-type diet (PD)
  • Nordic Nutrition Recommendation (NNR)
  • Type 2 diabetes mellitus (T2DM)
  • Insulin sensitivity
  • Weight loss
  • Myo-inositol (MI)
  • 1,5-anhydroglucitol (1,5-AG)
ispartof: Metabolomics, 2016, Vol.12(5), pp.1-14
description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11306-016-1013-x Byline: Elin Chorell (1,4,5), Mats Ryberg (1), Christel Larsson (2), Susanne Sandberg (1), Caroline Mellberg (1), Bernt Lindahl (1), Henrik Antti (3,5), Tommy Olsson (1) Keywords: Metabolomics; Mass spectrometry; Multivariate analysis; Paleolithic-type diet (PD); Nordic Nutrition Recommendation (NNR); Type 2 diabetes mellitus (T2DM); Insulin sensitivity; Weight loss; Myo-inositol (MI); 1,5-anhydroglucitol (1,5-AG) Abstract: Background Menopause is associated with increased abdominal fat and increased risk of developing diabetes and cardiovascular disease. Objectives The present study evaluated the plasma metabolic response in relation to insulin sensitivity after weight loss via diet intervention. Methods This work includes two studies i) Ten women on a 5 weeks Paleolithic-type diet (PD, 30 energy percent (E%) protein, 40 E% fat, 30 E% carbohydrates), ii) 55 women on 6 months of either PD or Nordic Nutrition Recommendations diet (NNR, 15 E% protein, 30 E% fat, and 55 E% carbohydrates). Plasma metabolic profiles were acquired at baseline and post diet using gas chromatography time-of-flight/mass spectrometry and investigated in relation to insulin sensitivity using multivariate bioinformatics. Results Both the PD and NNR diet resulted in significant weight loss, reduced waist circumference, improved serum lipid profiles, and improved insulin sensitivity. We detected a baseline metabolic profile that correlated significantly with insulin sensitivity, and of which components increased significantly in the PD group compared to NNR. Specifically, a significant increase in myo-inositol (MI), a second messenger of insulin action, and [beta]-hydroxybutyric acid ([beta]-HB) increased while dihomo-gamma-linoleic acid (DGLA) decreased in PD compared to NNR, which correlated with improved insulin sensitivity. We also detected a significant decrease in tyrosine and tryptophan, potential markers of insulin resistance when elevated in the circulation, with the PD but not the NNR. Conclusions Using metabolomics, we detected changes in the plasma metabolite profiles associated with weight loss in postmenopausal women by different diets. The metabolic profiles following 6 months of PD were linked to beneficial effects on insulin sensitivity compared to NNR. Graphical Abstract Author Affiliation: (1) Department of Public Health
language: eng
source:
identifier: ISSN: 1573-3882 ; E-ISSN: 1573-3890 ; DOI: 10.1007/s11306-016-1013-x
fulltext: fulltext
issn:
  • 1573-3890
  • 15733890
  • 1573-3882
  • 15733882
url: Link


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titlePlasma metabolomic response to postmenopausal weight loss induced by different diets
creatorChorell, Elin ; Ryberg, Mats ; Larsson, Christel ; Sandberg, Susanne ; Mellberg, Caroline ; Lindahl, Bernt ; Antti, Henrik ; Olsson, Tommy
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subjectMetabolomics ; Mass spectrometry ; Multivariate analysis ; Paleolithic-type diet (PD) ; Nordic Nutrition Recommendation (NNR) ; Type 2 diabetes mellitus (T2DM) ; Insulin sensitivity ; Weight loss ; Myo-inositol (MI) ; 1,5-anhydroglucitol (1,5-AG)
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descriptionTo access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11306-016-1013-x Byline: Elin Chorell (1,4,5), Mats Ryberg (1), Christel Larsson (2), Susanne Sandberg (1), Caroline Mellberg (1), Bernt Lindahl (1), Henrik Antti (3,5), Tommy Olsson (1) Keywords: Metabolomics; Mass spectrometry; Multivariate analysis; Paleolithic-type diet (PD); Nordic Nutrition Recommendation (NNR); Type 2 diabetes mellitus (T2DM); Insulin sensitivity; Weight loss; Myo-inositol (MI); 1,5-anhydroglucitol (1,5-AG) Abstract: Background Menopause is associated with increased abdominal fat and increased risk of developing diabetes and cardiovascular disease. Objectives The present study evaluated the plasma metabolic response in relation to insulin sensitivity after weight loss via diet intervention. Methods This work includes two studies i) Ten women on a 5 weeks Paleolithic-type diet (PD, 30 energy percent (E%) protein, 40 E% fat, 30 E% carbohydrates), ii) 55 women on 6 months of either PD or Nordic Nutrition Recommendations diet (NNR, 15 E% protein, 30 E% fat, and 55 E% carbohydrates). Plasma metabolic profiles were acquired at baseline and post diet using gas chromatography time-of-flight/mass spectrometry and investigated in relation to insulin sensitivity using multivariate bioinformatics. Results Both the PD and NNR diet resulted in significant weight loss, reduced waist circumference, improved serum lipid profiles, and improved insulin sensitivity. We detected a baseline metabolic profile that correlated significantly with insulin sensitivity, and of which components increased significantly in the PD group compared to NNR. Specifically, a significant increase in myo-inositol (MI), a second messenger of insulin action, and [beta]-hydroxybutyric acid ([beta]-HB) increased while dihomo-gamma-linoleic acid (DGLA) decreased in PD compared to NNR, which correlated with improved insulin sensitivity. We also detected a significant decrease in tyrosine and tryptophan, potential markers of insulin resistance when elevated in the circulation, with the PD but not the NNR. Conclusions Using metabolomics, we detected changes in the plasma metabolite profiles associated with weight loss in postmenopausal women by different diets. The metabolic profiles following 6 months of PD were linked to beneficial effects on insulin sensitivity compared to NNR. Graphical Abstract Author Affiliation: (1) Department of Public Health and Clinical Medicine, Medicine, Umea University, Umea, Sweden (2) Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden (3) Department of Chemistry, Umea University, Umea, Sweden (4) Norrlands University Hospital, Umea University, Bldg 6 M, SE-901 87, Umea, Sweden (5) Computational Life Science Cluster (CLiC), Umea University, Umea, Sweden Article History: Registration Date: 08/03/2016 Received Date: 28/10/2015 Accepted Date: 01/02/2016 Online Date: 16/03/2016 Article note: Henrik Antti and Tommy Olsson have shared senior authorship.
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