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Scrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa

Two new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa , collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a ∆ 24,25 exomethylene on the side chains, res... Full description

Journal Title: Journal of Natural Medicines 2019, Vol.73(4), pp.814-819
Main Author: Jomori, Takahiro
Other Authors: Shiroyama, Shuji , Ise, Yuji , Kohtsuka, Hisanori , Matsuda, Kenichi , Kuranaga, Takefumi , Wakimoto, Toshiyuki
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1340-3443 ; E-ISSN: 1861-0293 ; DOI: 10.1007/s11418-019-01315-6
Link: http://dx.doi.org/10.1007/s11418-019-01315-6
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recordid: springer_jour10.1007/s11418-019-01315-6
title: Scrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa
format: Article
creator:
  • Jomori, Takahiro
  • Shiroyama, Shuji
  • Ise, Yuji
  • Kohtsuka, Hisanori
  • Matsuda, Kenichi
  • Kuranaga, Takefumi
  • Wakimoto, Toshiyuki
subjects:
  • Scrobiculoside
  • Deep-sea sponge
  • Pachastrella scrobiculosa
  • Cytotoxicity
ispartof: Journal of Natural Medicines, 2019, Vol.73(4), pp.814-819
description: Two new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa , collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a ∆ 24,25 exomethylene on the side chains, respectively. Both saponins have a common sugar moiety composed of β- d -galactopyranosyl-(1 → 2)-6-acetyl-β- d -glucopyranoside, with the exception of an acetyl group on C6″ in scrobiculoside A. Scrobiculoside A exhibited cytotoxicity against HL-60 and P388 cells, with IC 50 values of 52 and 61 μM, respectively.
language: eng
source:
identifier: ISSN: 1340-3443 ; E-ISSN: 1861-0293 ; DOI: 10.1007/s11418-019-01315-6
fulltext: fulltext
issn:
  • 1861-0293
  • 18610293
  • 1340-3443
  • 13403443
url: Link


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titleScrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa
creatorJomori, Takahiro ; Shiroyama, Shuji ; Ise, Yuji ; Kohtsuka, Hisanori ; Matsuda, Kenichi ; Kuranaga, Takefumi ; Wakimoto, Toshiyuki
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subjectScrobiculoside ; Deep-sea sponge ; Pachastrella scrobiculosa ; Cytotoxicity
descriptionTwo new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa , collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a ∆ 24,25 exomethylene on the side chains, respectively. Both saponins have a common sugar moiety composed of β- d -galactopyranosyl-(1 → 2)-6-acetyl-β- d -glucopyranoside, with the exception of an acetyl group on C6″ in scrobiculoside A. Scrobiculoside A exhibited cytotoxicity against HL-60 and P388 cells, with IC 50 values of 52 and 61 μM, respectively.
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titleScrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa
descriptionTwo new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa , collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a ∆ 24,25 exomethylene on the side chains, respectively. Both saponins have a common sugar moiety composed of β- d -galactopyranosyl-(1 → 2)-6-acetyl-β- d -glucopyranoside, with the exception of an acetyl group on C6″ in scrobiculoside A. Scrobiculoside A exhibited cytotoxicity against HL-60 and P388 cells, with IC 50 values of 52 and 61 μM, respectively.
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titleScrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa
authorJomori, Takahiro ; Shiroyama, Shuji ; Ise, Yuji ; Kohtsuka, Hisanori ; Matsuda, Kenichi ; Kuranaga, Takefumi ; Wakimoto, Toshiyuki
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abstractTwo new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa , collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a ∆ 24,25 exomethylene on the side chains, respectively. Both saponins have a common sugar moiety composed of β- d -galactopyranosyl-(1 → 2)-6-acetyl-β- d -glucopyranoside, with the exception of an acetyl group on C6″ in scrobiculoside A. Scrobiculoside A exhibited cytotoxicity against HL-60 and P388 cells, with IC 50 values of 52 and 61 μM, respectively.
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doi10.1007/s11418-019-01315-6
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date2019-09-13