schliessen

Filtern

 

Bibliotheken

Epigenetic regulators sculpt the plastic brain

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11515-017-1465-z Byline: Ji-Song Guan (2), Hong Xie (1), San-Xiong Liu (1) Keywords: epigenetic; activity-dependent gene expression; memory; neurological diseases Abst... Full description

Journal Title: Frontiers in Biology 2017, Vol.12(5), pp.317-332
Main Author: Guan, Ji-Song
Other Authors: Xie, Hong , Liu, San-Xiong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1674-7984 ; E-ISSN: 1674-7992 ; DOI: 10.1007/s11515-017-1465-z
Link: http://dx.doi.org/10.1007/s11515-017-1465-z
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: springer_jour10.1007/s11515-017-1465-z
title: Epigenetic regulators sculpt the plastic brain
format: Article
creator:
  • Guan, Ji-Song
  • Xie, Hong
  • Liu, San-Xiong
subjects:
  • epigenetic
  • activity-dependent gene expression
  • memory
  • neurological diseases
ispartof: Frontiers in Biology, 2017, Vol.12(5), pp.317-332
description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11515-017-1465-z Byline: Ji-Song Guan (2), Hong Xie (1), San-Xiong Liu (1) Keywords: epigenetic; activity-dependent gene expression; memory; neurological diseases Abstract: Background Epigenetic regulation is a level of transcriptional regulation that occurs in addition to the genetic programming found in biological systems. In the brain, the epigenetic machinery gives the system an opportunity to adapt to a given environment to help not only the individual but also the species survive and expand. However, such a regulatory system has risks, as mutations resulting from epigenetic regulation can cause severe neurological or psychiatric disorders. Objective Here, we review the most recent findings regarding the epigenetic mechanisms that control the activitydependent gene transcription leading to synaptic plasticity and brain function and the defects in these mechanisms that lead to neurological disorders. Methods A search was carried out systematically, searching all relevant publications up to June 2017, using the PubMed search engine. The following keywords were used: "activity induced epigenetic," "gene transcription," and "neurological disorders." Results Awide range of studies focused on the roles of epigenetics in transgenerational inheritance, neural differentiation, neural circuit assembly and brain diseases. Thirty-one articles focused specifically on activity-induced epigenetic modifications that regulated gene transcription and memory formation and consolidation. Conclusion Activity-dependent epigenetic mechanisms of gene expression regulation contribute to basic neuronal physiology, and defects were associated with an elevated risk for brain disorders. Author Affiliation: (1) School of Life Sciences, Tsinghua University, Beijing, 100084, China (2) ShanghaiTech University, Shanghai, 201210, China Article History: Registration Date: 25/10/2017 Received Date: 23/06/2017 Accepted Date: 17/08/2017 Online Date: 26/10/2017
language: eng
source:
identifier: ISSN: 1674-7984 ; E-ISSN: 1674-7992 ; DOI: 10.1007/s11515-017-1465-z
fulltext: fulltext
issn:
  • 1674-7992
  • 16747992
  • 1674-7984
  • 16747984
url: Link


@attributes
ID1467440720
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1007/s11515-017-1465-z
sourceidspringer_jour
recordidTN_springer_jour10.1007/s11515-017-1465-z
sourcesystemOther
pqid1966488533
galeid515131933
display
typearticle
titleEpigenetic regulators sculpt the plastic brain
creatorGuan, Ji-Song ; Xie, Hong ; Liu, San-Xiong
ispartofFrontiers in Biology, 2017, Vol.12(5), pp.317-332
identifier
subjectepigenetic ; activity-dependent gene expression ; memory ; neurological diseases
languageeng
source
descriptionTo access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11515-017-1465-z Byline: Ji-Song Guan (2), Hong Xie (1), San-Xiong Liu (1) Keywords: epigenetic; activity-dependent gene expression; memory; neurological diseases Abstract: Background Epigenetic regulation is a level of transcriptional regulation that occurs in addition to the genetic programming found in biological systems. In the brain, the epigenetic machinery gives the system an opportunity to adapt to a given environment to help not only the individual but also the species survive and expand. However, such a regulatory system has risks, as mutations resulting from epigenetic regulation can cause severe neurological or psychiatric disorders. Objective Here, we review the most recent findings regarding the epigenetic mechanisms that control the activitydependent gene transcription leading to synaptic plasticity and brain function and the defects in these mechanisms that lead to neurological disorders. Methods A search was carried out systematically, searching all relevant publications up to June 2017, using the PubMed search engine. The following keywords were used: "activity induced epigenetic," "gene transcription," and "neurological disorders." Results Awide range of studies focused on the roles of epigenetics in transgenerational inheritance, neural differentiation, neural circuit assembly and brain diseases. Thirty-one articles focused specifically on activity-induced epigenetic modifications that regulated gene transcription and memory formation and consolidation. Conclusion Activity-dependent epigenetic mechanisms of gene expression regulation contribute to basic neuronal physiology, and defects were associated with an elevated risk for brain disorders. Author Affiliation: (1) School of Life Sciences, Tsinghua University, Beijing, 100084, China (2) ShanghaiTech University, Shanghai, 201210, China Article History: Registration Date: 25/10/2017 Received Date: 23/06/2017 Accepted Date: 17/08/2017 Online Date: 26/10/2017
version4
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://dx.doi.org/10.1007/s11515-017-1465-z$$EView_full_text_in_Springer_(Subscribers_only)
search
creatorcontrib
0Guan, Ji-Song
1Xie, Hong
2Liu, San-Xiong
titleEpigenetic regulators sculpt the plastic brain
subject
0epigenetic
1activity-dependent gene expression
2memory
3neurological diseases
general
010.1007/s11515-017-1465-z
1English
2Springer Science & Business Media B.V.
3SpringerLink
sourceidspringer_jour
recordidspringer_jour10.1007/s11515-017-1465-z
issn
01674-7992
116747992
21674-7984
316747984
rsrctypearticle
creationdate2017
addtitle
0Frontiers in Biology
1Selected Publications from Chinese Universities
2Front. Biol.
searchscopespringer_journals_complete
scopespringer_journals_complete
lsr30VSR-Enriched:[pqid, description, galeid, pages]
sort
titleEpigenetic regulators sculpt the plastic brain
authorGuan, Ji-Song ; Xie, Hong ; Liu, San-Xiong
creationdate20171000
facets
frbrgroupid-4790931728905543473
frbrtype5
newrecords20171122
languageeng
creationdate2017
topic
0Epigenetic
1Activity-Dependent Gene Expression
2Memory
3Neurological Diseases
collectionSpringerLink
prefilterarticles
rsrctypearticles
creatorcontrib
0Guan, Ji-Song
1Xie, Hong
2Liu, San-Xiong
jtitleFrontiers In Biology
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Guan
1Xie
2Liu
aufirst
0Ji-Song
1Hong
2San-Xiong
au
0Guan, Ji-Song
1Xie, Hong
2Liu, San-Xiong
atitleEpigenetic regulators sculpt the plastic brain
jtitleFrontiers in Biology
stitleFront. Biol.
addtitleSelected Publications from Chinese Universities
risdate201710
volume12
issue5
spage317
epage332
issn1674-7984
eissn1674-7992
genrearticle
ristypeJOUR
copBeijing
pubHigher Education Press
doi10.1007/s11515-017-1465-z
pages317-332
date2017-10