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A review of computational models of bone fracture healing

In the process of fracture healing, there are many cellular and molecular events that are regulated by mechanical stimuli and biochemical signals. To explore the unknown mechanisms underlying bone fracture healing, optimal fixation configurations, and the design of new treatment strategies, computat... Full description

Journal Title: Medical & Biological Engineering & Computing 2017, Vol.55(11), pp.1895-1914
Main Author: Wang, Monan
Other Authors: Yang, Ning , Wang, Xinyu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0140-0118 ; E-ISSN: 1741-0444 ; DOI: 10.1007/s11517-017-1701-3
Link: http://dx.doi.org/10.1007/s11517-017-1701-3
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recordid: springer_jour10.1007/s11517-017-1701-3
title: A review of computational models of bone fracture healing
format: Article
creator:
  • Wang, Monan
  • Yang, Ning
  • Wang, Xinyu
subjects:
  • Fracture healing
  • Computational biology
  • Mechanical stimuli
  • Biochemical signals
ispartof: Medical & Biological Engineering & Computing, 2017, Vol.55(11), pp.1895-1914
description: In the process of fracture healing, there are many cellular and molecular events that are regulated by mechanical stimuli and biochemical signals. To explore the unknown mechanisms underlying bone fracture healing, optimal fixation configurations, and the design of new treatment strategies, computational healing models provide a good solution. With the simulation of mechanoregulatory healing models, bioregulatory healing models and coupled mechanobioregulatory healing models, healing outcomes can be predicted. In this review, first, we provide an overview of current computational healing models. Their clinical applications are also presented. Then, the limitations of current models and their corresponding solutions are discussed in this review. Finally, future potentials are presented in this review. Multiscale modeling from the intracellular level to the tissue level is essential, and more clinical applications of computational healing models are required in future research.
language: eng
source:
identifier: ISSN: 0140-0118 ; E-ISSN: 1741-0444 ; DOI: 10.1007/s11517-017-1701-3
fulltext: fulltext
issn:
  • 1741-0444
  • 17410444
  • 0140-0118
  • 01400118
url: Link


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subjectFracture healing ; Computational biology ; Mechanical stimuli ; Biochemical signals
descriptionIn the process of fracture healing, there are many cellular and molecular events that are regulated by mechanical stimuli and biochemical signals. To explore the unknown mechanisms underlying bone fracture healing, optimal fixation configurations, and the design of new treatment strategies, computational healing models provide a good solution. With the simulation of mechanoregulatory healing models, bioregulatory healing models and coupled mechanobioregulatory healing models, healing outcomes can be predicted. In this review, first, we provide an overview of current computational healing models. Their clinical applications are also presented. Then, the limitations of current models and their corresponding solutions are discussed in this review. Finally, future potentials are presented in this review. Multiscale modeling from the intracellular level to the tissue level is essential, and more clinical applications of computational healing models are required in future research.
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descriptionIn the process of fracture healing, there are many cellular and molecular events that are regulated by mechanical stimuli and biochemical signals. To explore the unknown mechanisms underlying bone fracture healing, optimal fixation configurations, and the design of new treatment strategies, computational healing models provide a good solution. With the simulation of mechanoregulatory healing models, bioregulatory healing models and coupled mechanobioregulatory healing models, healing outcomes can be predicted. In this review, first, we provide an overview of current computational healing models. Their clinical applications are also presented. Then, the limitations of current models and their corresponding solutions are discussed in this review. Finally, future potentials are presented in this review. Multiscale modeling from the intracellular level to the tissue level is essential, and more clinical applications of computational healing models are required in future research.
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abstractIn the process of fracture healing, there are many cellular and molecular events that are regulated by mechanical stimuli and biochemical signals. To explore the unknown mechanisms underlying bone fracture healing, optimal fixation configurations, and the design of new treatment strategies, computational healing models provide a good solution. With the simulation of mechanoregulatory healing models, bioregulatory healing models and coupled mechanobioregulatory healing models, healing outcomes can be predicted. In this review, first, we provide an overview of current computational healing models. Their clinical applications are also presented. Then, the limitations of current models and their corresponding solutions are discussed in this review. Finally, future potentials are presented in this review. Multiscale modeling from the intracellular level to the tissue level is essential, and more clinical applications of computational healing models are required in future research.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
doi10.1007/s11517-017-1701-3
pages1895-1914
date2017-11