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Expression and Clinical Significance of l -Plastin in Colorectal Carcinoma

Byline: Jing Li (1), Ren Zhao (1) Keywords: l-plastin; Colorectal carcinoma; Tumour marker; Carcinoembryonic antigen; Tumour grading; Clinical significance Abstract: Introduction l-plastin, an actin-binding protein, is upregulated in many tumours, including colorectal carcinoma. This study evaluated... Full description

Journal Title: Journal of Gastrointestinal Surgery 2011, Vol.15(11), pp.1982-1988
Main Author: Li, Jing
Other Authors: Zhao, Ren
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1091-255X ; E-ISSN: 1873-4626 ; DOI: 10.1007/s11605-011-1678-4
Link: http://dx.doi.org/10.1007/s11605-011-1678-4
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recordid: springer_jour10.1007/s11605-011-1678-4
title: Expression and Clinical Significance of l -Plastin in Colorectal Carcinoma
format: Article
creator:
  • Li, Jing
  • Zhao, Ren
subjects:
  • -plastin
  • Colorectal carcinoma
  • Tumour marker
  • Carcinoembryonic antigen
  • Tumour grading
  • Clinical significance
ispartof: Journal of Gastrointestinal Surgery, 2011, Vol.15(11), pp.1982-1988
description: Byline: Jing Li (1), Ren Zhao (1) Keywords: l-plastin; Colorectal carcinoma; Tumour marker; Carcinoembryonic antigen; Tumour grading; Clinical significance Abstract: Introduction l-plastin, an actin-binding protein, is upregulated in many tumours, including colorectal carcinoma. This study evaluated the expression of l-plastin in plasma and colorectal tumour tissue and analysed the correlation between clinicopathological staging and prognosis. Materials and Methods Enzyme-linked immunosorbent assay was used to detect l-plastin in the plasma of 120 colorectal carcinoma patients and 40 control subjects. Immunohistochemistry analyses were also used. Results The rate of positive l-plastin expression was significantly higher in colorectal carcinoma patients than in control subjects, and was significantly higher in tumour tissues than in the tissues surrounding the tumour. l-Plastin expression also is correlated with tumour grade and size, and lymph node metastasis. However, there was no correlation with the extent of tumour invasion or distant metastasis. Conclusion l-Plastin may be a useful marker for screening colorectal carcinoma and determining the prognosis of patients with colorectal carcinoma, and for genetic therapy and targeted therapy of colorectal carcinoma. Author Affiliation: (1) Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University, No.197 Ruijin Er Road, Shanghai, 200025, China Article History: Registration Date: 07/09/2011 Received Date: 09/11/2010 Accepted Date: 07/09/2011 Online Date: 16/09/2011
language: eng
source:
identifier: ISSN: 1091-255X ; E-ISSN: 1873-4626 ; DOI: 10.1007/s11605-011-1678-4
fulltext: fulltext
issn:
  • 1873-4626
  • 18734626
  • 1091-255X
  • 1091255X
url: Link


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descriptionByline: Jing Li (1), Ren Zhao (1) Keywords: l-plastin; Colorectal carcinoma; Tumour marker; Carcinoembryonic antigen; Tumour grading; Clinical significance Abstract: Introduction l-plastin, an actin-binding protein, is upregulated in many tumours, including colorectal carcinoma. This study evaluated the expression of l-plastin in plasma and colorectal tumour tissue and analysed the correlation between clinicopathological staging and prognosis. Materials and Methods Enzyme-linked immunosorbent assay was used to detect l-plastin in the plasma of 120 colorectal carcinoma patients and 40 control subjects. Immunohistochemistry analyses were also used. Results The rate of positive l-plastin expression was significantly higher in colorectal carcinoma patients than in control subjects, and was significantly higher in tumour tissues than in the tissues surrounding the tumour. l-Plastin expression also is correlated with tumour grade and size, and lymph node metastasis. However, there was no correlation with the extent of tumour invasion or distant metastasis. Conclusion l-Plastin may be a useful marker for screening colorectal carcinoma and determining the prognosis of patients with colorectal carcinoma, and for genetic therapy and targeted therapy of colorectal carcinoma. Author Affiliation: (1) Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University, No.197 Ruijin Er Road, Shanghai, 200025, China Article History: Registration Date: 07/09/2011 Received Date: 09/11/2010 Accepted Date: 07/09/2011 Online Date: 16/09/2011
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