schliessen

Filtern

 

Bibliotheken

Effects of Trimethoxystilbene on Proliferation and Apoptosis of Pulmonary Artery Smooth Muscle Cells

Proliferation of pulmonary artery smooth muscle cells (PASMC) is an important contributor to the progress of pulmonary arterial hypertension (PAH). Anti-inflammatory therapies may have therapeutic applicability for PAH. Resveratrol (RES) has prominent anti-inflammatory effects in vitro, but in vivo... Full description

Journal Title: Cell Biochemistry and Biophysics 2012, Vol.64(2), pp.101-106
Main Author: Gao, Ge
Other Authors: Wang, Xin , Qin, Xiaoqun , Jiang, Xinyu , Xiang, Daxiong , Xie, Li , Hu, Jianguo , Gao, Jiesheng
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1085-9195 ; E-ISSN: 1559-0283 ; DOI: 10.1007/s12013-012-9377-7
Link: http://dx.doi.org/10.1007/s12013-012-9377-7
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: springer_jour10.1007/s12013-012-9377-7
title: Effects of Trimethoxystilbene on Proliferation and Apoptosis of Pulmonary Artery Smooth Muscle Cells
format: Article
creator:
  • Gao, Ge
  • Wang, Xin
  • Qin, Xiaoqun
  • Jiang, Xinyu
  • Xiang, Daxiong
  • Xie, Li
  • Hu, Jianguo
  • Gao, Jiesheng
subjects:
  • Trimethoxystilbene
  • Resveratrol
  • Pulmonary artery smooth muscles cells
  • Pulmonary hypertension
  • Apoptosis
ispartof: Cell Biochemistry and Biophysics, 2012, Vol.64(2), pp.101-106
description: Proliferation of pulmonary artery smooth muscle cells (PASMC) is an important contributor to the progress of pulmonary arterial hypertension (PAH). Anti-inflammatory therapies may have therapeutic applicability for PAH. Resveratrol (RES) has prominent anti-inflammatory effects in vitro, but in vivo its beneficial effects are limited by short systemic half life and poor lipotrophy. A derivative of RES, trimethoxystilbene (TMS), has higher lipotropy and extended half life compared with RES, and can potentially overcome the limitations of RES. In the present study, we studied the effects of TMS and RES on proliferation and apoptosis of PASMC stimulated with Tumor Necrosis Factor-α. The effects on PASMC proliferation were quantified by MTT, while apoptosis was assessed by flow cytometry (Annexin V/propidium iodide assay). We observed strong inhibitory effects of TMS on the growth of PASMC, and these effects were 20 times more potent than those of RES. We further documented induction of apoptosis in PASMC treated with TMS, again, to a higher degree than with RES. In conclusion, TMS is more potent than RES in the inhibition of proliferation and induction of apoptosis of PASMC, demonstrating its potentially beneficial role for treating PAH.
language: eng
source:
identifier: ISSN: 1085-9195 ; E-ISSN: 1559-0283 ; DOI: 10.1007/s12013-012-9377-7
fulltext: fulltext
issn:
  • 1559-0283
  • 15590283
  • 1085-9195
  • 10859195
url: Link


@attributes
ID295414411
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid10.1007/s12013-012-9377-7
sourceidspringer_jour
recordidTN_springer_jour10.1007/s12013-012-9377-7
sourcesystemOther
pqid1112160081
display
typearticle
titleEffects of Trimethoxystilbene on Proliferation and Apoptosis of Pulmonary Artery Smooth Muscle Cells
creatorGao, Ge ; Wang, Xin ; Qin, Xiaoqun ; Jiang, Xinyu ; Xiang, Daxiong ; Xie, Li ; Hu, Jianguo ; Gao, Jiesheng
ispartofCell Biochemistry and Biophysics, 2012, Vol.64(2), pp.101-106
identifier
subjectTrimethoxystilbene ; Resveratrol ; Pulmonary artery smooth muscles cells ; Pulmonary hypertension ; Apoptosis
descriptionProliferation of pulmonary artery smooth muscle cells (PASMC) is an important contributor to the progress of pulmonary arterial hypertension (PAH). Anti-inflammatory therapies may have therapeutic applicability for PAH. Resveratrol (RES) has prominent anti-inflammatory effects in vitro, but in vivo its beneficial effects are limited by short systemic half life and poor lipotrophy. A derivative of RES, trimethoxystilbene (TMS), has higher lipotropy and extended half life compared with RES, and can potentially overcome the limitations of RES. In the present study, we studied the effects of TMS and RES on proliferation and apoptosis of PASMC stimulated with Tumor Necrosis Factor-α. The effects on PASMC proliferation were quantified by MTT, while apoptosis was assessed by flow cytometry (Annexin V/propidium iodide assay). We observed strong inhibitory effects of TMS on the growth of PASMC, and these effects were 20 times more potent than those of RES. We further documented induction of apoptosis in PASMC treated with TMS, again, to a higher degree than with RES. In conclusion, TMS is more potent than RES in the inhibition of proliferation and induction of apoptosis of PASMC, demonstrating its potentially beneficial role for treating PAH.
languageeng
source
version5
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://dx.doi.org/10.1007/s12013-012-9377-7$$EView_full_text_in_Springer_(Subscribers_only)
search
creatorcontrib
0Gao, Ge
1Wang, Xin
2Qin, Xiaoqun
3Jiang, Xinyu
4Xiang, Daxiong
5Xie, Li
6Hu, Jianguo
7Gao, Jiesheng
titleEffects of Trimethoxystilbene on Proliferation and Apoptosis of Pulmonary Artery Smooth Muscle Cells
descriptionProliferation of pulmonary artery smooth muscle cells (PASMC) is an important contributor to the progress of pulmonary arterial hypertension (PAH). Anti-inflammatory therapies may have therapeutic applicability for PAH. Resveratrol (RES) has prominent anti-inflammatory effects in vitro, but in vivo its beneficial effects are limited by short systemic half life and poor lipotrophy. A derivative of RES, trimethoxystilbene (TMS), has higher lipotropy and extended half life compared with RES, and can potentially overcome the limitations of RES. In the present study, we studied the effects of TMS and RES on proliferation and apoptosis of PASMC stimulated with Tumor Necrosis Factor-α. The effects on PASMC proliferation were quantified by MTT, while apoptosis was assessed by flow cytometry (Annexin V/propidium iodide assay). We observed strong inhibitory effects of TMS on the growth of PASMC, and these effects were 20 times more potent than those of RES. We further documented induction of apoptosis in PASMC treated with TMS, again, to a higher degree than with RES. In conclusion, TMS is more potent than RES in the inhibition of proliferation and induction of apoptosis of PASMC, demonstrating its potentially beneficial role for treating PAH.
subject
0Trimethoxystilbene
1Resveratrol
2Pulmonary artery smooth muscles cells
3Pulmonary hypertension
4Apoptosis
general
010.1007/s12013-012-9377-7
1English
2Springer Science & Business Media B.V.
3SpringerLink
sourceidspringer_jour
recordidspringer_jour10.1007/s12013-012-9377-7
issn
01559-0283
115590283
21085-9195
310859195
rsrctypearticle
creationdate2012
addtitle
0Cell Biochemistry and Biophysics
1Cell Biochem Biophys
searchscopespringer_journals_complete
scopespringer_journals_complete
lsr30VSR-Enriched:[pages, pqid]
sort
titleEffects of Trimethoxystilbene on Proliferation and Apoptosis of Pulmonary Artery Smooth Muscle Cells
authorGao, Ge ; Wang, Xin ; Qin, Xiaoqun ; Jiang, Xinyu ; Xiang, Daxiong ; Xie, Li ; Hu, Jianguo ; Gao, Jiesheng
creationdate20121100
facets
frbrgroupid8493146960184640526
frbrtype5
languageeng
creationdate2012
topic
0Trimethoxystilbene
1Resveratrol
2Pulmonary Artery Smooth Muscles Cells
3Pulmonary Hypertension
4Apoptosis
collectionSpringerLink
prefilterarticles
rsrctypearticles
creatorcontrib
0Gao, Ge
1Wang, Xin
2Qin, Xiaoqun
3Jiang, Xinyu
4Xiang, Daxiong
5Xie, Li
6Hu, Jianguo
7Gao, Jiesheng
jtitleCell Biochemistry And Biophysics
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Gao
1Wang
2Qin
3Jiang
4Xiang
5Xie
6Hu
aufirst
0Ge
1Xin
2Xiaoqun
3Xinyu
4Daxiong
5Li
6Jianguo
7Jiesheng
au
0Gao, Ge
1Wang, Xin
2Qin, Xiaoqun
3Jiang, Xinyu
4Xiang, Daxiong
5Xie, Li
6Hu, Jianguo
7Gao, Jiesheng
atitleEffects of Trimethoxystilbene on Proliferation and Apoptosis of Pulmonary Artery Smooth Muscle Cells
jtitleCell Biochemistry and Biophysics
stitleCell Biochem Biophys
risdate201211
volume64
issue2
spage101
epage106
issn1085-9195
eissn1559-0283
genrearticle
ristypeJOUR
abstractProliferation of pulmonary artery smooth muscle cells (PASMC) is an important contributor to the progress of pulmonary arterial hypertension (PAH). Anti-inflammatory therapies may have therapeutic applicability for PAH. Resveratrol (RES) has prominent anti-inflammatory effects in vitro, but in vivo its beneficial effects are limited by short systemic half life and poor lipotrophy. A derivative of RES, trimethoxystilbene (TMS), has higher lipotropy and extended half life compared with RES, and can potentially overcome the limitations of RES. In the present study, we studied the effects of TMS and RES on proliferation and apoptosis of PASMC stimulated with Tumor Necrosis Factor-α. The effects on PASMC proliferation were quantified by MTT, while apoptosis was assessed by flow cytometry (Annexin V/propidium iodide assay). We observed strong inhibitory effects of TMS on the growth of PASMC, and these effects were 20 times more potent than those of RES. We further documented induction of apoptosis in PASMC treated with TMS, again, to a higher degree than with RES. In conclusion, TMS is more potent than RES in the inhibition of proliferation and induction of apoptosis of PASMC, demonstrating its potentially beneficial role for treating PAH.
copNew York
pubSpringer-Verlag
doi10.1007/s12013-012-9377-7
pages101-6
date2012-11