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Serum thyrotropin level of 30 μIU/mL is inadequate for preablative thyroglobulin to serve as a prognostic marker for differentiated thyroid cancer

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12020-015-0842-0 Byline: Teng Zhao (1,4), Jun Liang (2), Zhenqing Guo (3), Jiao Li (4), Yansong Lin (1) Keywords: Differentiated thyroid cancer; Thyrotropin; Thyroglob... Full description

Journal Title: Endocrine 2016, Vol.53(1), pp.166-173
Main Author: Zhao, Teng
Other Authors: Liang, Jun , Guo, Zhenqing , Li, Jiao , Lin, Yansong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1355-008X ; E-ISSN: 1559-0100 ; DOI: 10.1007/s12020-015-0842-0
Link: http://dx.doi.org/10.1007/s12020-015-0842-0
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recordid: springer_jour10.1007/s12020-015-0842-0
title: Serum thyrotropin level of 30 μIU/mL is inadequate for preablative thyroglobulin to serve as a prognostic marker for differentiated thyroid cancer
format: Article
creator:
  • Zhao, Teng
  • Liang, Jun
  • Guo, Zhenqing
  • Li, Jiao
  • Lin, Yansong
subjects:
  • Differentiated thyroid cancer
  • Thyrotropin
  • Thyroglobulin
  • Radioactive iodine therapy
ispartof: Endocrine, 2016, Vol.53(1), pp.166-173
description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12020-015-0842-0 Byline: Teng Zhao (1,4), Jun Liang (2), Zhenqing Guo (3), Jiao Li (4), Yansong Lin (1) Keywords: Differentiated thyroid cancer; Thyrotropin; Thyroglobulin; Radioactive iodine therapy Abstract: Purpose Preablative-stimulated thyroglobulin (ps-Tg) has manifested its potential for predicting prognosis in patients with differentiated thyroid carcinoma (DTC), but its level can be affected by thyrotropin (TSH). The objective of this study was to evaluate the utility of ps-Tg in predicting individual response after radioactive iodine (RAI) therapy, and further explore the appropriate TSH level for ps-Tg to serve as a prognostic marker in DTC without initial distant metastasis (DM). Methods A total of 208 consecutive non-DM DTC patients with serial ps-Tg, TSH, and anti-Tg antibody (TgAb) measured simultaneously were enrolled. The initial and last measurements of ps-Tg were marked as Tg1 and Tg2, respectively, with a median interval of 8 days, so does TSH. Clinical response was retrospectively evaluated as excellent, indeterminate, biochemical incomplete, or structural incomplete response (ER, IDR, BIR, or SIR) after a mean follow-up of 21.5 months. Tg1 and Tg2 were tested and compared for their performances in predicting ER and incomplete response (IR, including BIR and SIR) by receiver operating characteristic (ROC) curve analysis. The 416 ps-Tg levels (Tg1 and Tg2) were then categorized by their corresponding TSH grouping of 30-
language: eng
source:
identifier: ISSN: 1355-008X ; E-ISSN: 1559-0100 ; DOI: 10.1007/s12020-015-0842-0
fulltext: fulltext
issn:
  • 1559-0100
  • 15590100
  • 1355-008X
  • 1355008X
url: Link


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titleSerum thyrotropin level of 30 μIU/mL is inadequate for preablative thyroglobulin to serve as a prognostic marker for differentiated thyroid cancer
creatorZhao, Teng ; Liang, Jun ; Guo, Zhenqing ; Li, Jiao ; Lin, Yansong
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