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Curdlan blocks the immune suppression by myeloid-derived suppressor cells and reduces tumor burden

Tumor-elicited immunosuppression is one of the essential mechanisms for tumor evasion of immune surveillance. It is widely thought to be one of the main reasons for the failure of tumor immunotherapy. Myeloid-derived suppressor cells (MDSCs) comprise a heterogeneous population of cells that play an... Full description

Journal Title: Immunologic Research 2016, Vol.64(4), pp.931-939
Main Author: Rui, Ke
Other Authors: Tian, Jie , Tang, Xinyi , Ma, Jie , Xu, Ping , Tian, Xinyu , Wang, Yungang , Xu, Huaxi , Lu, Liwei , Wang, Shengjun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0257-277X ; E-ISSN: 1559-0755 ; DOI: 10.1007/s12026-016-8789-7
Link: http://dx.doi.org/10.1007/s12026-016-8789-7
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recordid: springer_jour10.1007/s12026-016-8789-7
title: Curdlan blocks the immune suppression by myeloid-derived suppressor cells and reduces tumor burden
format: Article
creator:
  • Rui, Ke
  • Tian, Jie
  • Tang, Xinyi
  • Ma, Jie
  • Xu, Ping
  • Tian, Xinyu
  • Wang, Yungang
  • Xu, Huaxi
  • Lu, Liwei
  • Wang, Shengjun
subjects:
  • Curdlan
  • Myeloid-derived suppressor cells
  • Immune suppression
  • Anti-tumor immunity
ispartof: Immunologic Research, 2016, Vol.64(4), pp.931-939
description: Tumor-elicited immunosuppression is one of the essential mechanisms for tumor evasion of immune surveillance. It is widely thought to be one of the main reasons for the failure of tumor immunotherapy. Myeloid-derived suppressor cells (MDSCs) comprise a heterogeneous population of cells that play an important role in tumor-induced immunosuppression. These cells expand in tumor-bearing individuals and suppress T cell responses via various mechanisms. Curdlan, the linear (1 → 3)-β-glucan from Agrobacterium , has been applied in the food industry and other sectors. The anti-tumor property of curdlan has been recognized for a long time although the underlying mechanism still needs to be explored. In this study, we investigated the effect of curdlan on MDSCs and found that curdlan could promote MDSCs to differentiate into a more mature state and then significantly reduce the suppressive function of MDSCs, decrease the MDSCs in vivo and down-regulate the suppression in tumor-bearing mice, thus leading to enhanced anti-tumor immune responses. We, therefore, increase the understanding of further mechanisms by which curdlan achieves anti-tumor effects.
language: eng
source:
identifier: ISSN: 0257-277X ; E-ISSN: 1559-0755 ; DOI: 10.1007/s12026-016-8789-7
fulltext: fulltext
issn:
  • 1559-0755
  • 15590755
  • 0257-277X
  • 0257277X
url: Link


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titleCurdlan blocks the immune suppression by myeloid-derived suppressor cells and reduces tumor burden
creatorRui, Ke ; Tian, Jie ; Tang, Xinyi ; Ma, Jie ; Xu, Ping ; Tian, Xinyu ; Wang, Yungang ; Xu, Huaxi ; Lu, Liwei ; Wang, Shengjun
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subjectCurdlan ; Myeloid-derived suppressor cells ; Immune suppression ; Anti-tumor immunity
descriptionTumor-elicited immunosuppression is one of the essential mechanisms for tumor evasion of immune surveillance. It is widely thought to be one of the main reasons for the failure of tumor immunotherapy. Myeloid-derived suppressor cells (MDSCs) comprise a heterogeneous population of cells that play an important role in tumor-induced immunosuppression. These cells expand in tumor-bearing individuals and suppress T cell responses via various mechanisms. Curdlan, the linear (1 → 3)-β-glucan from Agrobacterium , has been applied in the food industry and other sectors. The anti-tumor property of curdlan has been recognized for a long time although the underlying mechanism still needs to be explored. In this study, we investigated the effect of curdlan on MDSCs and found that curdlan could promote MDSCs to differentiate into a more mature state and then significantly reduce the suppressive function of MDSCs, decrease the MDSCs in vivo and down-regulate the suppression in tumor-bearing mice, thus leading to enhanced anti-tumor immune responses. We, therefore, increase the understanding of further mechanisms by which curdlan achieves anti-tumor effects.
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abstractTumor-elicited immunosuppression is one of the essential mechanisms for tumor evasion of immune surveillance. It is widely thought to be one of the main reasons for the failure of tumor immunotherapy. Myeloid-derived suppressor cells (MDSCs) comprise a heterogeneous population of cells that play an important role in tumor-induced immunosuppression. These cells expand in tumor-bearing individuals and suppress T cell responses via various mechanisms. Curdlan, the linear (1 → 3)-β-glucan from Agrobacterium , has been applied in the food industry and other sectors. The anti-tumor property of curdlan has been recognized for a long time although the underlying mechanism still needs to be explored. In this study, we investigated the effect of curdlan on MDSCs and found that curdlan could promote MDSCs to differentiate into a more mature state and then significantly reduce the suppressive function of MDSCs, decrease the MDSCs in vivo and down-regulate the suppression in tumor-bearing mice, thus leading to enhanced anti-tumor immune responses. We, therefore, increase the understanding of further mechanisms by which curdlan achieves anti-tumor effects.
copNew York
pubSpringer US
doi10.1007/s12026-016-8789-7
pages931-939
date2016-08