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Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

Cancer is one of the major malignant diseases in the world. Current anti tumor agents are restricted during the chemotherapy due to their poor solubility in aqueous media, multidrug resistance problems, cytotoxicity, and serious side effects to healthy tissues. Development of targeted drug nanocarri... Full description

Journal Title: Molecular Biotechnology 2015, Vol.57(3), pp.201-218
Main Author: Ghaz-Jahanian, Mohammad
Other Authors: Abbaspour-Aghdam, Farzin , Anarjan, Navideh , Berenjian, Aydin , Jafarizadeh-Malmiri, Hoda
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1073-6085 ; E-ISSN: 1559-0305 ; DOI: 10.1007/s12033-014-9816-3
Link: http://dx.doi.org/10.1007/s12033-014-9816-3
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recordid: springer_jour10.1007/s12033-014-9816-3
title: Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery
format: Article
creator:
  • Ghaz-Jahanian, Mohammad
  • Abbaspour-Aghdam, Farzin
  • Anarjan, Navideh
  • Berenjian, Aydin
  • Jafarizadeh-Malmiri, Hoda
subjects:
  • Tumor
  • Nanocarrier
  • Chitosan
  • Targeted drug delivery
  • Efficacy mechanisms
ispartof: Molecular Biotechnology, 2015, Vol.57(3), pp.201-218
description: Cancer is one of the major malignant diseases in the world. Current anti tumor agents are restricted during the chemotherapy due to their poor solubility in aqueous media, multidrug resistance problems, cytotoxicity, and serious side effects to healthy tissues. Development of targeted drug nanocarriers would enhance the undesirable effects of anticancer drugs and also selectively deliver them to cancerous tissues. Variety of nanocarriers such as micelles, polymeric nanoparticles, liposomes nanogels, dendrimers, and carbon nanotubes have been used for targeted delivery of anticancer agents. These nanocarriers transfer loaded drugs to desired sites through passive or active efficacy mechanisms. Chitosan and its derivatives, due to their unique properties such as hydrophilicity, biocompatibility, and biodegradability, have attracted attention to be used in nanocarriers. Grafting cancer-specific ligands onto the Chitosan nanoparticles, which leads to ligand–receptor interactions, has been successfully developed as active targeting. Chitosan-conjugated components also respond to external or internal physical and chemical stimulus in targeted tumors that is called environment triggers. In this study, mechanisms of targeted tumor deliveries via nanocarriers were explained; specifically, chitosan-based nanocarriers in tumor-targeting drug delivery were also discussed.
language: eng
source:
identifier: ISSN: 1073-6085 ; E-ISSN: 1559-0305 ; DOI: 10.1007/s12033-014-9816-3
fulltext: fulltext
issn:
  • 1559-0305
  • 15590305
  • 1073-6085
  • 10736085
url: Link


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titleApplication of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery
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subjectTumor ; Nanocarrier ; Chitosan ; Targeted drug delivery ; Efficacy mechanisms
descriptionCancer is one of the major malignant diseases in the world. Current anti tumor agents are restricted during the chemotherapy due to their poor solubility in aqueous media, multidrug resistance problems, cytotoxicity, and serious side effects to healthy tissues. Development of targeted drug nanocarriers would enhance the undesirable effects of anticancer drugs and also selectively deliver them to cancerous tissues. Variety of nanocarriers such as micelles, polymeric nanoparticles, liposomes nanogels, dendrimers, and carbon nanotubes have been used for targeted delivery of anticancer agents. These nanocarriers transfer loaded drugs to desired sites through passive or active efficacy mechanisms. Chitosan and its derivatives, due to their unique properties such as hydrophilicity, biocompatibility, and biodegradability, have attracted attention to be used in nanocarriers. Grafting cancer-specific ligands onto the Chitosan nanoparticles, which leads to ligand–receptor interactions, has been successfully developed as active targeting. Chitosan-conjugated components also respond to external or internal physical and chemical stimulus in targeted tumors that is called environment triggers. In this study, mechanisms of targeted tumor deliveries via nanocarriers were explained; specifically, chitosan-based nanocarriers in tumor-targeting drug delivery were also discussed.
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abstractCancer is one of the major malignant diseases in the world. Current anti tumor agents are restricted during the chemotherapy due to their poor solubility in aqueous media, multidrug resistance problems, cytotoxicity, and serious side effects to healthy tissues. Development of targeted drug nanocarriers would enhance the undesirable effects of anticancer drugs and also selectively deliver them to cancerous tissues. Variety of nanocarriers such as micelles, polymeric nanoparticles, liposomes nanogels, dendrimers, and carbon nanotubes have been used for targeted delivery of anticancer agents. These nanocarriers transfer loaded drugs to desired sites through passive or active efficacy mechanisms. Chitosan and its derivatives, due to their unique properties such as hydrophilicity, biocompatibility, and biodegradability, have attracted attention to be used in nanocarriers. Grafting cancer-specific ligands onto the Chitosan nanoparticles, which leads to ligand–receptor interactions, has been successfully developed as active targeting. Chitosan-conjugated components also respond to external or internal physical and chemical stimulus in targeted tumors that is called environment triggers. In this study, mechanisms of targeted tumor deliveries via nanocarriers were explained; specifically, chitosan-based nanocarriers in tumor-targeting drug delivery were also discussed.
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pages201-218
date2015-03