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Nanomaterials for the Capture and Therapeutic Targeting of Circulating Tumor Cells

Circulating tumor cells are a hallmark of cancer metastasis which accounts for approximately 90% of all cancer-related deaths. Their detection and characterization have significant implications in cancer biology and clinical practice. However, CTCs are rare cells and consist of heterogeneous subpopu... Full description

Journal Title: Cellular and Molecular Bioengineering 2017, Vol.10(4), pp.275-294
Main Author: Zhang, Zhenjiang
Other Authors: King, Michael
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1865-5025 ; E-ISSN: 1865-5033 ; DOI: 10.1007/s12195-017-0497-4
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recordid: springer_jour10.1007/s12195-017-0497-4
title: Nanomaterials for the Capture and Therapeutic Targeting of Circulating Tumor Cells
format: Article
creator:
  • Zhang, Zhenjiang
  • King, Michael
subjects:
  • Cancer
  • Metastasis
  • Circulating tumor cells
  • Nanomedicine
  • Nanomaterials
  • Nanoparticles
ispartof: Cellular and Molecular Bioengineering, 2017, Vol.10(4), pp.275-294
description: Circulating tumor cells are a hallmark of cancer metastasis which accounts for approximately 90% of all cancer-related deaths. Their detection and characterization have significant implications in cancer biology and clinical practice. However, CTCs are rare cells and consist of heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and isolate them with high efficiency. Nanomaterials, with unique structural and functional properties, have shown strong promise to meet the challenging demands. In this review, we discuss CTC capture and therapeutic targeting, emphasizing the significance of the nanomaterials being used for this purpose. The next generation of therapy for metastatic cancer may well involve capturing and even directly neutralizing CTCs using nanomaterials.
language: eng
source:
identifier: ISSN: 1865-5025 ; E-ISSN: 1865-5033 ; DOI: 10.1007/s12195-017-0497-4
fulltext: fulltext_linktorsrc
issn:
  • 1865-5033
  • 18655033
  • 1865-5025
  • 18655025
url: Link


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subjectCancer ; Metastasis ; Circulating tumor cells ; Nanomedicine ; Nanomaterials ; Nanoparticles
descriptionCirculating tumor cells are a hallmark of cancer metastasis which accounts for approximately 90% of all cancer-related deaths. Their detection and characterization have significant implications in cancer biology and clinical practice. However, CTCs are rare cells and consist of heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and isolate them with high efficiency. Nanomaterials, with unique structural and functional properties, have shown strong promise to meet the challenging demands. In this review, we discuss CTC capture and therapeutic targeting, emphasizing the significance of the nanomaterials being used for this purpose. The next generation of therapy for metastatic cancer may well involve capturing and even directly neutralizing CTCs using nanomaterials.
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abstractCirculating tumor cells are a hallmark of cancer metastasis which accounts for approximately 90% of all cancer-related deaths. Their detection and characterization have significant implications in cancer biology and clinical practice. However, CTCs are rare cells and consist of heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and isolate them with high efficiency. Nanomaterials, with unique structural and functional properties, have shown strong promise to meet the challenging demands. In this review, we discuss CTC capture and therapeutic targeting, emphasizing the significance of the nanomaterials being used for this purpose. The next generation of therapy for metastatic cancer may well involve capturing and even directly neutralizing CTCs using nanomaterials.
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doi10.1007/s12195-017-0497-4
pages275-294
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