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EGF-loaded nanofibrous scaffold for skin tissue engineering applications

In this study, nanofibers of poly(lactic- co -glycolic acid) with a core-shell structure encapsulating epidermal growth factor (EGF) were prepared through emulsion electrospinning technique. The morphology and the core-shell structure of the nanofibers were observed by field emission scanning electr... Full description

Journal Title: Fibers and Polymers 2015, Vol.16(4), pp.782-787
Main Author: Norouzi, Mohammad
Other Authors: Shabani, Iman , Atyabi, Fatemeh , Soleimani, Masoud
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1229-9197 ; E-ISSN: 1875-0052 ; DOI: 10.1007/s12221-015-0782-6
Link: http://dx.doi.org/10.1007/s12221-015-0782-6
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recordid: springer_jour10.1007/s12221-015-0782-6
title: EGF-loaded nanofibrous scaffold for skin tissue engineering applications
format: Article
creator:
  • Norouzi, Mohammad
  • Shabani, Iman
  • Atyabi, Fatemeh
  • Soleimani, Masoud
subjects:
  • Emulsion electrospinning
  • Nanofibrous scaffolds
  • Epidermal growth factor
  • Skin tissue engineering
  • Poly(lactic-co-glycolic acid)
ispartof: Fibers and Polymers, 2015, Vol.16(4), pp.782-787
description: In this study, nanofibers of poly(lactic- co -glycolic acid) with a core-shell structure encapsulating epidermal growth factor (EGF) were prepared through emulsion electrospinning technique. The morphology and the core-shell structure of the nanofibers were observed by field emission scanning electron microscopy and transmission electron microscopy, respectively. The release profile of EGF indicated a continuous release of the protein over one week. Biocompatibility of the plasma-treated scaffolds was evaluated using MTT assay for human fibroblast cells. The results demonstrated desirable biocompatibility and bioactivity of the scaffolds with the capability of encapsulation and controlled release of EGF which can be utilized in skin tissue engineering applications.
language: eng
source:
identifier: ISSN: 1229-9197 ; E-ISSN: 1875-0052 ; DOI: 10.1007/s12221-015-0782-6
fulltext: fulltext
issn:
  • 1875-0052
  • 18750052
  • 1229-9197
  • 12299197
url: Link


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subjectEmulsion electrospinning ; Nanofibrous scaffolds ; Epidermal growth factor ; Skin tissue engineering ; Poly(lactic-co-glycolic acid)
descriptionIn this study, nanofibers of poly(lactic- co -glycolic acid) with a core-shell structure encapsulating epidermal growth factor (EGF) were prepared through emulsion electrospinning technique. The morphology and the core-shell structure of the nanofibers were observed by field emission scanning electron microscopy and transmission electron microscopy, respectively. The release profile of EGF indicated a continuous release of the protein over one week. Biocompatibility of the plasma-treated scaffolds was evaluated using MTT assay for human fibroblast cells. The results demonstrated desirable biocompatibility and bioactivity of the scaffolds with the capability of encapsulation and controlled release of EGF which can be utilized in skin tissue engineering applications.
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abstractIn this study, nanofibers of poly(lactic- co -glycolic acid) with a core-shell structure encapsulating epidermal growth factor (EGF) were prepared through emulsion electrospinning technique. The morphology and the core-shell structure of the nanofibers were observed by field emission scanning electron microscopy and transmission electron microscopy, respectively. The release profile of EGF indicated a continuous release of the protein over one week. Biocompatibility of the plasma-treated scaffolds was evaluated using MTT assay for human fibroblast cells. The results demonstrated desirable biocompatibility and bioactivity of the scaffolds with the capability of encapsulation and controlled release of EGF which can be utilized in skin tissue engineering applications.
copSeoul
pubThe Korean Fiber Society
doi10.1007/s12221-015-0782-6
pages782-787
date2015-04