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Rsf-1 overexpression in human prostate cancer, implication as a prognostic marker

Rsf-1 (HBXAP) was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells. However, the expression of Rsf-1 and its clinical significance in human prostate cancer have not been reported. In the present study, we analyzed the expression patt... Full description

Journal Title: Tumor Biology 2014, Vol.35(6), pp.5771-5776
Main Author: Li, Hui
Other Authors: Zhang, Yi , Zhang, Yue , Bai, Xue , Peng, Yang , He, Ping
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1010-4283 ; E-ISSN: 1423-0380 ; DOI: 10.1007/s13277-014-1766-7
Link: http://dx.doi.org/10.1007/s13277-014-1766-7
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recordid: springer_jour10.1007/s13277-014-1766-7
title: Rsf-1 overexpression in human prostate cancer, implication as a prognostic marker
format: Article
creator:
  • Li, Hui
  • Zhang, Yi
  • Zhang, Yue
  • Bai, Xue
  • Peng, Yang
  • He, Ping
subjects:
  • Rsf-1
  • Prostate cancer
  • Prognosis
  • Proliferation
ispartof: Tumor Biology, 2014, Vol.35(6), pp.5771-5776
description: Rsf-1 (HBXAP) was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells. However, the expression of Rsf-1 and its clinical significance in human prostate cancer have not been reported. In the present study, we analyzed the expression pattern of Rsf-1 in human prostate cancer tissues and found that Rsf-1 was overexpressed in 45 % of prostate cancer specimens. There was a significant association between Rsf-1 overexpression and tumor stage ( p  = 0.0039) and preoperative PSA level ( p  = 0.015). Furthermore, Rsf-1 overexpression correlated with poor biomedical recurrence-free survival in prostate cancer patients ( p  
language: eng
source:
identifier: ISSN: 1010-4283 ; E-ISSN: 1423-0380 ; DOI: 10.1007/s13277-014-1766-7
fulltext: fulltext
issn:
  • 1423-0380
  • 14230380
  • 1010-4283
  • 10104283
url: Link


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titleRsf-1 overexpression in human prostate cancer, implication as a prognostic marker
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subjectRsf-1 ; Prostate cancer ; Prognosis ; Proliferation
descriptionRsf-1 (HBXAP) was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells. However, the expression of Rsf-1 and its clinical significance in human prostate cancer have not been reported. In the present study, we analyzed the expression pattern of Rsf-1 in human prostate cancer tissues and found that Rsf-1 was overexpressed in 45 % of prostate cancer specimens. There was a significant association between Rsf-1 overexpression and tumor stage ( p  = 0.0039) and preoperative PSA level ( p  = 0.015). Furthermore, Rsf-1 overexpression correlated with poor biomedical recurrence-free survival in prostate cancer patients ( p  < 0.001). Rsf-1 overexpression could serve as an independent predictor for poor recurrence-free survival ( p  = 0.012). In addition, small interfering RNA (siRNA) knockdown in DU145 cells with high endogenous Rsf-1 expression decrease cell proliferation, colony formation, and invasion. In conclusion, Rsf-1 is overexpressed in human prostate cancers and serves as a novel prognostic marker. Rsf-1 contributes to prostate cancer cell growth and invasion, which makes it a candidate therapeutic target.
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titleRsf-1 overexpression in human prostate cancer, implication as a prognostic marker
descriptionRsf-1 (HBXAP) was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells. However, the expression of Rsf-1 and its clinical significance in human prostate cancer have not been reported. In the present study, we analyzed the expression pattern of Rsf-1 in human prostate cancer tissues and found that Rsf-1 was overexpressed in 45 % of prostate cancer specimens. There was a significant association between Rsf-1 overexpression and tumor stage ( p  = 0.0039) and preoperative PSA level ( p  = 0.015). Furthermore, Rsf-1 overexpression correlated with poor biomedical recurrence-free survival in prostate cancer patients ( p  < 0.001). Rsf-1 overexpression could serve as an independent predictor for poor recurrence-free survival ( p  = 0.012). In addition, small interfering RNA (siRNA) knockdown in DU145 cells with high endogenous Rsf-1 expression decrease cell proliferation, colony formation, and invasion. In conclusion, Rsf-1 is overexpressed in human prostate cancers and serves as a novel prognostic marker. Rsf-1 contributes to prostate cancer cell growth and invasion, which makes it a candidate therapeutic target.
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abstractRsf-1 (HBXAP) was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells. However, the expression of Rsf-1 and its clinical significance in human prostate cancer have not been reported. In the present study, we analyzed the expression pattern of Rsf-1 in human prostate cancer tissues and found that Rsf-1 was overexpressed in 45 % of prostate cancer specimens. There was a significant association between Rsf-1 overexpression and tumor stage ( p  = 0.0039) and preoperative PSA level ( p  = 0.015). Furthermore, Rsf-1 overexpression correlated with poor biomedical recurrence-free survival in prostate cancer patients ( p  < 0.001). Rsf-1 overexpression could serve as an independent predictor for poor recurrence-free survival ( p  = 0.012). In addition, small interfering RNA (siRNA) knockdown in DU145 cells with high endogenous Rsf-1 expression decrease cell proliferation, colony formation, and invasion. In conclusion, Rsf-1 is overexpressed in human prostate cancers and serves as a novel prognostic marker. Rsf-1 contributes to prostate cancer cell growth and invasion, which makes it a candidate therapeutic target.
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doi10.1007/s13277-014-1766-7
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date2014-06