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A possible connection between tumor necrosis factor alpha and adropin levels in polycystic ovary syndrome

Adropin is a peptide hormone implicated in the regulation of insulin sensitivity and energy homeostasis. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disease associated with insulin resistance. It has been demonstrated that various inflammatory markers increased in PCOS including... Full description

Journal Title: Journal of Endocrinological Investigation 2016, Vol.39(7), pp.747-754
Main Author: Kume, T.
Other Authors: Calan, M. , Yilmaz, O. , Kocabas, G. , Yesil, P. , Temur, M. , Bicer, M. , Calan, O.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1720-8386 ; DOI: 10.1007/s40618-016-0453-5
Link: http://dx.doi.org/10.1007/s40618-016-0453-5
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recordid: springer_jour10.1007/s40618-016-0453-5
title: A possible connection between tumor necrosis factor alpha and adropin levels in polycystic ovary syndrome
format: Article
creator:
  • Kume, T.
  • Calan, M.
  • Yilmaz, O.
  • Kocabas, G.
  • Yesil, P.
  • Temur, M.
  • Bicer, M.
  • Calan, O.
subjects:
  • Polycystic ovary syndrome
  • Adropin
  • Tumor necrosis factor-α
  • Insulin resistance
  • Cytokine
ispartof: Journal of Endocrinological Investigation, 2016, Vol.39(7), pp.747-754
description: Adropin is a peptide hormone implicated in the regulation of insulin sensitivity and energy homeostasis. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disease associated with insulin resistance. It has been demonstrated that various inflammatory markers increased in PCOS including TNF-α. TNF-α regulates the secretion of certain peptides which play a crucial role in glucose and lipid homeostasis. There is also some evidence of a link between TNF-α and adropin.To ascertain whether there is an association between circulating adropin levels and TNF-α in PCOS.152 women with PCOS and 152 age- and body mass index-matched controls without PCOS were recruited for this cross-sectional study.Adropin and TNF-α levels were measured using ELISA.Adropin levels were lower in the PCOS group compared with the control group (7.43 ± 0.79 vs. 9.42 ± 0.76 ng/ml, P 
language: eng
source:
identifier: E-ISSN: 1720-8386 ; DOI: 10.1007/s40618-016-0453-5
fulltext: fulltext
issn:
  • 1720-8386
  • 17208386
url: Link


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titleA possible connection between tumor necrosis factor alpha and adropin levels in polycystic ovary syndrome
creatorKume, T. ; Calan, M. ; Yilmaz, O. ; Kocabas, G. ; Yesil, P. ; Temur, M. ; Bicer, M. ; Calan, O.
ispartofJournal of Endocrinological Investigation, 2016, Vol.39(7), pp.747-754
identifierE-ISSN: 1720-8386 ; DOI: 10.1007/s40618-016-0453-5
subjectPolycystic ovary syndrome ; Adropin ; Tumor necrosis factor-α ; Insulin resistance ; Cytokine
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descriptionAdropin is a peptide hormone implicated in the regulation of insulin sensitivity and energy homeostasis. Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disease associated with insulin resistance. It has been demonstrated that various inflammatory markers increased in PCOS including TNF-α. TNF-α regulates the secretion of certain peptides which play a crucial role in glucose and lipid homeostasis. There is also some evidence of a link between TNF-α and adropin.To ascertain whether there is an association between circulating adropin levels and TNF-α in PCOS.152 women with PCOS and 152 age- and body mass index-matched controls without PCOS were recruited for this cross-sectional study.Adropin and TNF-α levels were measured using ELISA.Adropin levels were lower in the PCOS group compared with the control group (7.43 ± 0.79 vs. 9.42 ± 0.76 ng/ml, P < 0.001), whereas TNF-α levels were higher (49.93 ± 3.39 vs. 35.83 ± 2.47 pg/ml, P < 0.001). A strongly negative correlation was found between circulating adropin levels and TNF-α levels in women with PCOS (r = −0.407, P < 0.001). Binary logistic regression analysis revealed that decreased adropin levels were significantly associated with high odds of having PCOS, although, after adjustment for TNF-α, this link vanished. Additionally, multiple linear regression analysis showed that HOMA-IR and TFN-α independently predicted adropin levels.Serum adropin levels are significantly decreased in PCOS and are inversely associated with TNF-α. Further dissection of the nature of this association can open new therapeutic options for metabolic diseases.
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titleA possible connection between tumor necrosis factor alpha and adropin levels in polycystic ovary syndrome
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