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Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention

Byline: Shu-qin Ying (1,2), Mei-xiang Xiang (1,2), Lu Fang (3), Jian-an Wang (1,2) Keywords: Percutaneous coronary intervention; Restenosis; Ischemia-reperfusion injury; P-selectin; Magnesium; R54 Abstract: Objective This study aims to determine the mechanisms underlying restenosis and ischemia-repe... Full description

Journal Title: Journal of Zhejiang University SCIENCE B 2010, Vol.11(8), pp.575-582
Main Author: Ying, Shu-qin
Other Authors: Xiang, Mei-xiang , Fang, Lu , Wang, Jian-an
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1673-1581 ; E-ISSN: 1862-1783 ; DOI: 10.1631/jzus.B1001006
Link: http://dx.doi.org/10.1631/jzus.B1001006
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recordid: springer_jour10.1631/jzus.B1001006
title: Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention
format: Article
creator:
  • Ying, Shu-qin
  • Xiang, Mei-xiang
  • Fang, Lu
  • Wang, Jian-an
subjects:
  • Percutaneous coronary intervention
  • Restenosis
  • Ischemia-reperfusion injury
  • P-selectin
  • Magnesium
ispartof: Journal of Zhejiang University SCIENCE B, 2010, Vol.11(8), pp.575-582
description: Byline: Shu-qin Ying (1,2), Mei-xiang Xiang (1,2), Lu Fang (3), Jian-an Wang (1,2) Keywords: Percutaneous coronary intervention; Restenosis; Ischemia-reperfusion injury; P-selectin; Magnesium; R54 Abstract: Objective This study aims to determine the mechanisms underlying restenosis and ischemia-reperfusion injury of the myocardium after percutaneous coronary intervention (PCI). Methods: The present study examined serial changes (5 min, 30 min, 2 h, 6 h, and 24 h after PCI) in circulating P-selectin, plasminogen activator inhibitor-1 (PAI-1), magnesium (Mg), and creatine kinase-myocardial band fraction (CK-MB) levels, which may be associated with restenosis and myocardial injury in patients undergoing PCI. The occurrence rates of major adverse cardiovascular events were collected over a six-month follow-up. Results PCI induced an early elevation of P-selectin, which correlated positively with the inflation pressure used in the PCI procedure. PCI also caused a significant and sustained decrease in serum Mg in PCI patients, without an effect on PAI-1. An increase in CK-MB was observed in PCI patients, although values were within normal reference range. In addition, elevated P-selectin and decreased Mg measured shortly after the coronary angioplasty procedure were associated with recurrent treatment and heart failure, respectively. Conclusions Our study demonstrates that PCI induces temporal changes of P-selectin, Mg, and CK-MB, which may be involved in restenosis and ischemia-reperfusion injury. These findings highlight the need for using antiplatelet therapy and Mg to reduce the risks associated with PCI. Author Affiliation: (1) Department of Cardiology, Zhejiang University, Hangzhou, 310009, China (2) Cardiovascular Key Lab of Zhejiang Province, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China (3) Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia Article History: Registration Date: 28/07/2010 Received Date: 13/06/2010 Accepted Date: 30/06/2010 Online Date: 01/08/2010 Article note: The two authors contributed equally to this work Project (Nos. 2008CA056 and 391020-W50819) supported by the Medical Science Research Grant of the Health Bureau of Zhejiang Province, China
language: eng
source:
identifier: ISSN: 1673-1581 ; E-ISSN: 1862-1783 ; DOI: 10.1631/jzus.B1001006
fulltext: fulltext
issn:
  • 1862-1783
  • 18621783
  • 1673-1581
  • 16731581
url: Link


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titleTemporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention
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descriptionByline: Shu-qin Ying (1,2), Mei-xiang Xiang (1,2), Lu Fang (3), Jian-an Wang (1,2) Keywords: Percutaneous coronary intervention; Restenosis; Ischemia-reperfusion injury; P-selectin; Magnesium; R54 Abstract: Objective This study aims to determine the mechanisms underlying restenosis and ischemia-reperfusion injury of the myocardium after percutaneous coronary intervention (PCI). Methods: The present study examined serial changes (5 min, 30 min, 2 h, 6 h, and 24 h after PCI) in circulating P-selectin, plasminogen activator inhibitor-1 (PAI-1), magnesium (Mg), and creatine kinase-myocardial band fraction (CK-MB) levels, which may be associated with restenosis and myocardial injury in patients undergoing PCI. The occurrence rates of major adverse cardiovascular events were collected over a six-month follow-up. Results PCI induced an early elevation of P-selectin, which correlated positively with the inflation pressure used in the PCI procedure. PCI also caused a significant and sustained decrease in serum Mg in PCI patients, without an effect on PAI-1. An increase in CK-MB was observed in PCI patients, although values were within normal reference range. In addition, elevated P-selectin and decreased Mg measured shortly after the coronary angioplasty procedure were associated with recurrent treatment and heart failure, respectively. Conclusions Our study demonstrates that PCI induces temporal changes of P-selectin, Mg, and CK-MB, which may be involved in restenosis and ischemia-reperfusion injury. These findings highlight the need for using antiplatelet therapy and Mg to reduce the risks associated with PCI. Author Affiliation: (1) Department of Cardiology, Zhejiang University, Hangzhou, 310009, China (2) Cardiovascular Key Lab of Zhejiang Province, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China (3) Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia Article History: Registration Date: 28/07/2010 Received Date: 13/06/2010 Accepted Date: 30/06/2010 Online Date: 01/08/2010 Article note: The two authors contributed equally to this work Project (Nos. 2008CA056 and 391020-W50819) supported by the Medical Science Research Grant of the Health Bureau of Zhejiang Province, China
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