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Factors affecting cerebrospinal fluid opening pressure in patients with spontaneous intracranial hypotension

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1631/jzus.B1600343 Byline: Ling-ling Yao (1), Xing-yue Hu (1) Keywords: Spontaneous intracranial hypotension; Low cerebrospinal fluid opening pressure; Body mass index; Magn... Full description

Journal Title: Journal of Zhejiang University-SCIENCE B 2017, Vol.18(7), pp.577-585
Main Author: Yao, Ling-ling
Other Authors: Hu, Xing-yue
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1673-1581 ; E-ISSN: 1862-1783 ; DOI: 10.1631/jzus.B1600343
Link: http://dx.doi.org/10.1631/jzus.B1600343
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recordid: springer_jour10.1631/jzus.B1600343
title: Factors affecting cerebrospinal fluid opening pressure in patients with spontaneous intracranial hypotension
format: Article
creator:
  • Yao, Ling-ling
  • Hu, Xing-yue
subjects:
  • Spontaneous intracranial hypotension
  • Low cerebrospinal fluid opening pressure
  • Body mass index
  • Magnetic resonance imaging
ispartof: Journal of Zhejiang University-SCIENCE B, 2017, Vol.18(7), pp.577-585
description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1631/jzus.B1600343 Byline: Ling-ling Yao (1), Xing-yue Hu (1) Keywords: Spontaneous intracranial hypotension; Low cerebrospinal fluid opening pressure; Body mass index; Magnetic resonance imaging; R741; e*aaes.ecentsaa1/2a a1/2eeae[paragraph][sup.2]a1/4ae3/4a a1/2eaeae[degrees]; a[currency][acute accent]ecentsacentsa1/4*c[pounds sterling]a[+ or -]ae[macron] Abstract: Objectives Spontaneous intracranial hypotension (SIH) is recognized far more commonly than ever before. Though usually characterized by low cerebrospinal fluid (CSF) pressure, some patients with SIH are observed to have normal pressure values. In this study, we aimed to confirm the proportion of patients with normal CSF opening pressure (CSF OP) and explore the factors affecting CSF OP in SIH patients. Methods We retrospectively reviewed 206 consecutive SIH patients and analyzed their clinical and imaging variables (including demographic data, body mass index (BMI), duration of symptoms, and brain imaging findings). Univariate and multivariate analyses were performed to identify the potential factors affecting CSF OP. Results In a total of 114 (55.3%) cases the CSF OP was a[currency]60 mm[H.sub.2]O (1 mm[H.sub.2]O=9.806 65 Pa), in 90 (43.7%) cases it was between 60 and 200 mmH2O, and in 2 (1.0%) cases it was >200 mmH2O. Univariate analysis showed that the duration of symptoms (P
language: eng
source:
identifier: ISSN: 1673-1581 ; E-ISSN: 1862-1783 ; DOI: 10.1631/jzus.B1600343
fulltext: fulltext
issn:
  • 1862-1783
  • 18621783
  • 1673-1581
  • 16731581
url: Link


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titleFactors affecting cerebrospinal fluid opening pressure in patients with spontaneous intracranial hypotension
creatorYao, Ling-ling ; Hu, Xing-yue
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subjectSpontaneous intracranial hypotension ; Low cerebrospinal fluid opening pressure ; Body mass index ; Magnetic resonance imaging
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descriptionTo access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1631/jzus.B1600343 Byline: Ling-ling Yao (1), Xing-yue Hu (1) Keywords: Spontaneous intracranial hypotension; Low cerebrospinal fluid opening pressure; Body mass index; Magnetic resonance imaging; R741; e*aaes.ecentsaa1/2a a1/2eeae[paragraph][sup.2]a1/4ae3/4a a1/2eaeae[degrees]; a[currency][acute accent]ecentsacentsa1/4*c[pounds sterling]a[+ or -]ae[macron] Abstract: Objectives Spontaneous intracranial hypotension (SIH) is recognized far more commonly than ever before. Though usually characterized by low cerebrospinal fluid (CSF) pressure, some patients with SIH are observed to have normal pressure values. In this study, we aimed to confirm the proportion of patients with normal CSF opening pressure (CSF OP) and explore the factors affecting CSF OP in SIH patients. Methods We retrospectively reviewed 206 consecutive SIH patients and analyzed their clinical and imaging variables (including demographic data, body mass index (BMI), duration of symptoms, and brain imaging findings). Univariate and multivariate analyses were performed to identify the potential factors affecting CSF OP. Results In a total of 114 (55.3%) cases the CSF OP was a[currency]60 mm[H.sub.2]O (1 mm[H.sub.2]O=9.806 65 Pa), in 90 (43.7%) cases it was between 60 and 200 mmH2O, and in 2 (1.0%) cases it was >200 mmH2O. Univariate analysis showed that the duration of symptoms (P<0.001), BMI (P<0.001), and age (P=0.024) were positively correlated with CSF OP. However, multivariate analysis suggested that only the duration of symptoms (P<0.001) and BMI (P<0.001) were strongly correlated with CSF OP. A relatively high R .sup.2 of 0.681 was obtained for the multivariate model. Conclusion Our study indicated that in patients without a low CSF OP, a diagnosis of SIH should not be excluded. BMI and the duration of symptoms can influence CSF OP in SIH patients, and other potential factors need further investigation. ecentsc[R] a1/2[+ or -]ae*aaes.ecentsaa1/2aae[pounds sterling]eceeae[paragraph][sup.2]a1/4ae3/4acae1/2a[umlaut]a c[acute accent] c[R]c e[macron]a1/4[degrees]ae-[pounds sterling]a[cedilla][cedilla]eeae[paragraph][sup.2]a1/4ae3/4aa[umlaut]e*aaes.ecentsaa1/2a(SIH) ae[pounds sterling]ea[cedilla]-aea cae[macron]a3/4,a[sup.1][paragraph]aae-[yen]aecentse[R][umlaut]SIH ae[pounds sterling]ecee ae[paragraph][sup.2]a1/4ae3/4aca1/2[+ or -]aa c[acute accent] a aae[degrees]c[sup.1] ee a[currency]s.ae *ae[logical not]a[R][sup.1]ecca3/4e[macron]a[R]a*ae-[pounds sterling]a[cedilla][cedilla]eeae[paragraph][sup.2]a1/4ae3/4a a[umlaut]SIH ae[pounds sterling]ea[cedilla]-a e3/4e'ae[macron]a3/4,a[sup.1][paragraph]e a[cedilla]ae-[yen]a3/4a*a1/2eae ae[degrees]acc[paragraph]aec'-ae[paragraph]e[acute accent]a[cedilla]eeae[paragraph][sup.2]a1/4ae3/4aa-a[umlaut]ae3/4ec[cedilla] a[sup.3]aes.a ae[sup.1]ae[sup.3] ae 3/4a*206 a3/4a[umlaut]aeecentsc [R]e[macron]cSIH ae[pounds sterling]e,ae[paragraph]ea[paragraph]a** a[pounds sterling]a-[bar]a ae[macron]aa1/2eaeae[degrees]acc[paragraph]aec'-ae[paragraph]e[acute accent]aa1/2[+ or -]aae[pounds sterling]ae[yen] c'aec-e[micro]aeaee aaeaaeaa[currency]aeaaee[macron]a' a1/2[+ or -]aeeae[paragraph][sup.2]a1/4ae3/4acae1/2a[umlaut]a c[acute accent] a c'e[R]* ae[logical not]c c[c][paragraph]e a[cedilla]ae-[yen]e[macron]a[R]ae-[pounds sterling]a[cedilla][cedilla]eeae[paragraph][sup.2]a1/4ae3/4aa[umlaut]SIH ae[pounds sterling]e a[cedilla]-a[sup.1][paragraph]a[cedilla]a[degrees]es.,c[sup.1]a'ae[macron]e[pounds sterling]a*e[yen]eacc[paragraph]aec'-ae[paragraph]e[acute accent]e cae[pounds sterling]eae[currency]a*a1/2eaeae[degrees]acc[paragraph]aec'-ae[paragraph]e[acute accent],a'c[paragraph]a- a[umlaut]a[paragraph]a'ae*e[macron]a'ca c[acute accent] a1/2[+ or -]aSIH ae[pounds sterling]eceeae[paragraph][sup.2]a1/4 ae3/4aa[currency]s.a[degrees] Author Affiliation: (1) Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China Article History: Registration Date: 06/07/2017 Received Date: 01/08/2016 Accepted Date: 26/10/2016 Online Date: 18/07/2017 Article note: ORCID: Ling-ling YAO, http://orcid.org/0000-0002-1326-5097
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