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Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane

Decabromodiphenylethane (DBDPE) has been widely used as an alternative flame retardant due to the restriction or phase-out of traditional polybrominated diphenyl ethers (PBDEs), and is of increasing concern regarding its ubiquity, persistence, and potential adverse effects. In the present study, the... Full description

Journal Title: Journal of Zhejiang University-SCIENCE B 2018, Vol.19(5), pp.400-408
Main Author: Jin, Mei-qing
Other Authors: Zhang, Dong , Zhang, Ying , Zhou, Shan-shan , Lu, Xian-ting , Zhao, Hong-ting
Format: Electronic Article Electronic Article
Language: eng ; chi
Subjects:
ID: ISSN: 1673-1581 ; E-ISSN: 1862-1783 ; DOI: 10.1631/jzus.B1800033
Link: http://dx.doi.org/10.1631/jzus.B1800033
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recordid: springer_jour10.1631/jzus.B1800033
title: Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane
format: Article
creator:
  • Jin, Mei-qing
  • Zhang, Dong
  • Zhang, Ying
  • Zhou, Shan-shan
  • Lu, Xian-ting
  • Zhao, Hong-ting
subjects:
  • Decabromodiphenylethane
  • Flame retardant
  • Danio rerio
  • Neurotoxicity
ispartof: Journal of Zhejiang University-SCIENCE B, 2018, Vol.19(5), pp.400-408
description: Decabromodiphenylethane (DBDPE) has been widely used as an alternative flame retardant due to the restriction or phase-out of traditional polybrominated diphenyl ethers (PBDEs), and is of increasing concern regarding its ubiquity, persistence, and potential adverse effects. In the present study, the toxicological effects of DBDPE were evaluated using zebrafish as an in vivo model. Upon being exposed to DBDPE-polluted sediments for a short term, it was found that the mortality and malformation of zebrafish (including edema, bent notochord, and bent tail) were not affected even at the highest concentration tested (1000.0 μg/kg dry sediment). Regarding behavioral responses, it was found that zebrafish larvae of 48 hours post fertilization (hpf) in all groups escaped successfully with a touch to the dorsal fin. However, when exposed to the highest DBDPE concentration, the larvae of 120 hpf exhibited significantly smaller distances as compared to the control. Moreover, the results of the acetylcholinesterase (AChE) activity, the expression levels of two important nerve-related genes, and the cell apoptosis all indicated that DBDPE posed low neurotoxicity in embryo-larval zebrafish. The results in this study shed some light on the potential risks of DBDPE in the real environment and highlight the application of the sediment exposure route in the future.
language: eng ; chi
source:
identifier: ISSN: 1673-1581 ; E-ISSN: 1862-1783 ; DOI: 10.1631/jzus.B1800033
fulltext: fulltext
issn:
  • 1862-1783
  • 18621783
  • 1673-1581
  • 16731581
url: Link


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titleNeurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane
creatorJin, Mei-qing ; Zhang, Dong ; Zhang, Ying ; Zhou, Shan-shan ; Lu, Xian-ting ; Zhao, Hong-ting
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subjectDecabromodiphenylethane ; Flame retardant ; Danio rerio ; Neurotoxicity
descriptionDecabromodiphenylethane (DBDPE) has been widely used as an alternative flame retardant due to the restriction or phase-out of traditional polybrominated diphenyl ethers (PBDEs), and is of increasing concern regarding its ubiquity, persistence, and potential adverse effects. In the present study, the toxicological effects of DBDPE were evaluated using zebrafish as an in vivo model. Upon being exposed to DBDPE-polluted sediments for a short term, it was found that the mortality and malformation of zebrafish (including edema, bent notochord, and bent tail) were not affected even at the highest concentration tested (1000.0 μg/kg dry sediment). Regarding behavioral responses, it was found that zebrafish larvae of 48 hours post fertilization (hpf) in all groups escaped successfully with a touch to the dorsal fin. However, when exposed to the highest DBDPE concentration, the larvae of 120 hpf exhibited significantly smaller distances as compared to the control. Moreover, the results of the acetylcholinesterase (AChE) activity, the expression levels of two important nerve-related genes, and the cell apoptosis all indicated that DBDPE posed low neurotoxicity in embryo-larval zebrafish. The results in this study shed some light on the potential risks of DBDPE in the real environment and highlight the application of the sediment exposure route in the future.
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vertitle底泥中的十溴二苯乙烷的短期暴露对斑马鱼胚胎 和幼鱼神经毒性的研究
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titleNeurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane, 底泥中的十溴二苯乙烷的短期暴露对斑马鱼胚胎 和幼鱼神经毒性的研究
descriptionDecabromodiphenylethane (DBDPE) has been widely used as an alternative flame retardant due to the restriction or phase-out of traditional polybrominated diphenyl ethers (PBDEs), and is of increasing concern regarding its ubiquity, persistence, and potential adverse effects. In the present study, the toxicological effects of DBDPE were evaluated using zebrafish as an in vivo model. Upon being exposed to DBDPE-polluted sediments for a short term, it was found that the mortality and malformation of zebrafish (including edema, bent notochord, and bent tail) were not affected even at the highest concentration tested (1000.0 μg/kg dry sediment). Regarding behavioral responses, it was found that zebrafish larvae of 48 hours post fertilization (hpf) in all groups escaped successfully with a touch to the dorsal fin. However, when exposed to the highest DBDPE concentration, the larvae of 120 hpf exhibited significantly smaller distances as compared to the control. Moreover, the results of the acetylcholinesterase (AChE) activity, the expression levels of two important nerve-related genes, and the cell apoptosis all indicated that DBDPE posed low neurotoxicity in embryo-larval zebrafish. The results in this study shed some light on the potential risks of DBDPE in the real environment and highlight the application of the sediment exposure route in the future.
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titleNeurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane
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abstractDecabromodiphenylethane (DBDPE) has been widely used as an alternative flame retardant due to the restriction or phase-out of traditional polybrominated diphenyl ethers (PBDEs), and is of increasing concern regarding its ubiquity, persistence, and potential adverse effects. In the present study, the toxicological effects of DBDPE were evaluated using zebrafish as an in vivo model. Upon being exposed to DBDPE-polluted sediments for a short term, it was found that the mortality and malformation of zebrafish (including edema, bent notochord, and bent tail) were not affected even at the highest concentration tested (1000.0 μg/kg dry sediment). Regarding behavioral responses, it was found that zebrafish larvae of 48 hours post fertilization (hpf) in all groups escaped successfully with a touch to the dorsal fin. However, when exposed to the highest DBDPE concentration, the larvae of 120 hpf exhibited significantly smaller distances as compared to the control. Moreover, the results of the acetylcholinesterase (AChE) activity, the expression levels of two important nerve-related genes, and the cell apoptosis all indicated that DBDPE posed low neurotoxicity in embryo-larval zebrafish. The results in this study shed some light on the potential risks of DBDPE in the real environment and highlight the application of the sediment exposure route in the future.
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pubZhejiang University Press
doi10.1631/jzus.B1800033
pages400-408
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date2018-05