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Reduced UV-Induced Degradation of Doxorubicin Encapsulated in Polyethyleneglycol-Coated Liposomes

Purpose . The aim of this study was to investigate the stability of doxorubicin encapsulated in polyethyleneglycol-coated liposomes (Doxil™) under UV-A light. . High performance liquid chromatography and a fluorimetric method were used to quantify doxorubicin in bulk solution and doxorubicin in Doxi... Full description

Journal Title: Pharmaceutical Research 1999, Vol.16(6), pp.841-846
Main Author: Bandak, Suzan
Other Authors: Ramu, Avner , Barenholz, Yechezkel , Gabizon, Alberto
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0724-8741 ; E-ISSN: 1573-904X ; DOI: 10.1023/A:1018869818282
Link: http://dx.doi.org/10.1023/A:1018869818282
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recordid: springer_jour1018869818282
title: Reduced UV-Induced Degradation of Doxorubicin Encapsulated in Polyethyleneglycol-Coated Liposomes
format: Article
creator:
  • Bandak, Suzan
  • Ramu, Avner
  • Barenholz, Yechezkel
  • Gabizon, Alberto
subjects:
  • doxorubicin
  • liposomes
  • photodegradation
  • UV-A light
ispartof: Pharmaceutical Research, 1999, Vol.16(6), pp.841-846
description: Purpose . The aim of this study was to investigate the stability of doxorubicin encapsulated in polyethyleneglycol-coated liposomes (Doxil™) under UV-A light. . High performance liquid chromatography and a fluorimetric method were used to quantify doxorubicin in bulk solution and doxorubicin in Doxil formulation. . The photodegradation of Doxil was significantly lower in comparison to the photodegradation of the free drug and showed no concentration dependency at the measured concentration range of 5−50 μg/ml. During and after UV-A irradiation, there was no leakage of the drug from liposomes to the medium. After induced leakage of doxorubicin from the liposomes by the ionophore nigericin, the degradation kinetics of Doxil were identical to that of free doxorubicin. . High intraliposomal doxorubicin concentration and intraliposomal acidic pH are the two critical factors that protect DXR in Doxil from UV-A degradation.
language: eng
source:
identifier: ISSN: 0724-8741 ; E-ISSN: 1573-904X ; DOI: 10.1023/A:1018869818282
fulltext: fulltext
issn:
  • 1573-904X
  • 1573904X
  • 0724-8741
  • 07248741
url: Link


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titleReduced UV-Induced Degradation of Doxorubicin Encapsulated in Polyethyleneglycol-Coated Liposomes
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subjectdoxorubicin ; liposomes ; photodegradation ; UV-A light
descriptionPurpose . The aim of this study was to investigate the stability of doxorubicin encapsulated in polyethyleneglycol-coated liposomes (Doxil™) under UV-A light. . High performance liquid chromatography and a fluorimetric method were used to quantify doxorubicin in bulk solution and doxorubicin in Doxil formulation. . The photodegradation of Doxil was significantly lower in comparison to the photodegradation of the free drug and showed no concentration dependency at the measured concentration range of 5−50 μg/ml. During and after UV-A irradiation, there was no leakage of the drug from liposomes to the medium. After induced leakage of doxorubicin from the liposomes by the ionophore nigericin, the degradation kinetics of Doxil were identical to that of free doxorubicin. . High intraliposomal doxorubicin concentration and intraliposomal acidic pH are the two critical factors that protect DXR in Doxil from UV-A degradation.
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titleReduced UV-Induced Degradation of Doxorubicin Encapsulated in Polyethyleneglycol-Coated Liposomes
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0Purpose . The aim of this study was to investigate the stability of doxorubicin encapsulated in polyethyleneglycol-coated liposomes (Doxil™) under UV-A light.
1. High performance liquid chromatography and a fluorimetric method were used to quantify doxorubicin in bulk solution and doxorubicin in Doxil formulation.
2. The photodegradation of Doxil was significantly lower in comparison to the photodegradation of the free drug and showed no concentration dependency at the measured concentration range of 5−50 μg/ml. During and after UV-A irradiation, there was no leakage of the drug from liposomes to the medium. After induced leakage of doxorubicin from the liposomes by the ionophore nigericin, the degradation kinetics of Doxil were identical to that of free doxorubicin.
3. High intraliposomal doxorubicin concentration and intraliposomal acidic pH are the two critical factors that protect DXR in Doxil from UV-A degradation.
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titleReduced UV-Induced Degradation of Doxorubicin Encapsulated in Polyethyleneglycol-Coated Liposomes
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abstractPurpose . The aim of this study was to investigate the stability of doxorubicin encapsulated in polyethyleneglycol-coated liposomes (Doxil™) under UV-A light. . High performance liquid chromatography and a fluorimetric method were used to quantify doxorubicin in bulk solution and doxorubicin in Doxil formulation. . The photodegradation of Doxil was significantly lower in comparison to the photodegradation of the free drug and showed no concentration dependency at the measured concentration range of 5−50 μg/ml. During and after UV-A irradiation, there was no leakage of the drug from liposomes to the medium. After induced leakage of doxorubicin from the liposomes by the ionophore nigericin, the degradation kinetics of Doxil were identical to that of free doxorubicin. . High intraliposomal doxorubicin concentration and intraliposomal acidic pH are the two critical factors that protect DXR in Doxil from UV-A degradation.
copNew York
pubKluwer Academic Publishers-Plenum Publishers
doi10.1023/A:1018869818282
pages841-846
date1999-06