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Pathological changes in the immune organs of broiler chickens fed on corn naturally contaminated with aflatoxins B 1 and B 2

The purpose of this study was to evaluate the underlying basis for aflatoxin-induced immunosuppression in the broiler chicken by detecting pathological lesions and apoptosis in thymus, bursa of Fabricius (BF) and spleen. COBB500™ male broiler chicks were randomly allocated to two groups. The control... Full description

Journal Title: Avian Pathology 02 March 2015, p.1-26
Main Author: Peng, Xi
Other Authors: Bai, Shiping , Ding, Xuemei , Zeng, Qiufeng , Zhang, Keying , Fang, Jing
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Taylor & Francis
ID: ISSN: 0307-9457 ; E-ISSN: 1465-3338 ; DOI: 10.1080/03079457.2015.1023179
Link: http://dx.doi.org/10.1080/03079457.2015.1023179
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recordid: tayfranc10.1080/03079457.2015.1023179
title: Pathological changes in the immune organs of broiler chickens fed on corn naturally contaminated with aflatoxins B 1 and B 2
format: Article
creator:
  • Peng, Xi
  • Bai, Shiping
  • Ding, Xuemei
  • Zeng, Qiufeng
  • Zhang, Keying
  • Fang, Jing
subjects:
  • Bursa of Fabricius
  • Aflatoxin B1
  • Diets
  • Poultry
  • Apoptosis
  • Mucosal Immunity
  • Thymus
  • Spleen
  • Mitochondria
  • Lymphocytes
  • Flow Cytometry
  • Endoplasmic Reticulum
  • Nuclear Membranes
  • Red Pulp
  • Epithelium
  • Chaperones
  • Reticulocytes
  • Immunosuppression
  • Immunomodulation & Immunopharmacology
ispartof: Avian Pathology, 02 March 2015, p.1-26
description: The purpose of this study was to evaluate the underlying basis for aflatoxin-induced immunosuppression in the broiler chicken by detecting pathological lesions and apoptosis in thymus, bursa of Fabricius (BF) and spleen. COBB500™ male broiler chicks were randomly allocated to two groups. The control group was fed on a basal corn-based diet while the other group (the AFB group) was fed on a similar diet but the corn was naturally contaminated with aflatoxins B 1 and B 2 . Histopathological examination revealed that in the AFB group there was more nuclear debris in the three immune organs and obvious congestion of red pulp in the spleen, when compared with the control group. Ultrastructural examination showed lesions in the lymphocytes and reticulocytes of the three immune organs, the mucosal epithelium of the BF and the plasmocytes of spleen. Increased apoptotic cells and an impaired membrane system (including nuclear membrane, mitochondria and endoplasmic reticulum) could be observed in the three immune organs in birds of the AFB group. In the plasmocytes, dilated rough endoplasmic reticulum contained electron-dense matrix. By flow cytometery, the percentages of apoptosis were asignificantly higher ( P < 0.01) in the three organs of the AFB group than those of the control group. These observations suggested that the lesions of the immune organs were related to the immunosuppression, and that the apoptosis might be initiated by the mitochondrial pathway and ER chaperone pathway. Article just-accepted.
language: eng
source:
identifier: ISSN: 0307-9457 ; E-ISSN: 1465-3338 ; DOI: 10.1080/03079457.2015.1023179
fulltext: fulltext
issn:
  • 0307-9457
  • 03079457
  • 1465-3338
  • 14653338
url: Link


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titlePathological changes in the immune organs of broiler chickens fed on corn naturally contaminated with aflatoxins B 1 and B 2
creatorPeng, Xi ; Bai, Shiping ; Ding, Xuemei ; Zeng, Qiufeng ; Zhang, Keying ; Fang, Jing
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descriptionThe purpose of this study was to evaluate the underlying basis for aflatoxin-induced immunosuppression in the broiler chicken by detecting pathological lesions and apoptosis in thymus, bursa of Fabricius (BF) and spleen. COBB500™ male broiler chicks were randomly allocated to two groups. The control group was fed on a basal corn-based diet while the other group (the AFB group) was fed on a similar diet but the corn was naturally contaminated with aflatoxins B 1 and B 2 . Histopathological examination revealed that in the AFB group there was more nuclear debris in the three immune organs and obvious congestion of red pulp in the spleen, when compared with the control group. Ultrastructural examination showed lesions in the lymphocytes and reticulocytes of the three immune organs, the mucosal epithelium of the BF and the plasmocytes of spleen. Increased apoptotic cells and an impaired membrane system (including nuclear membrane, mitochondria and endoplasmic reticulum) could be observed in the three immune organs in birds of the AFB group. In the plasmocytes, dilated rough endoplasmic reticulum contained electron-dense matrix. By flow cytometery, the percentages of apoptosis were asignificantly higher ( P < 0.01) in the three organs of the AFB group than those of the control group. These observations suggested that the lesions of the immune organs were related to the immunosuppression, and that the apoptosis might be initiated by the mitochondrial pathway and ER chaperone pathway. Article just-accepted.
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subjectBursa of Fabricius ; Aflatoxin B1 ; Diets ; Poultry ; Apoptosis ; Mucosal Immunity ; Thymus ; Spleen ; Mitochondria ; Lymphocytes ; Flow Cytometry ; Endoplasmic Reticulum ; Nuclear Membranes ; Red Pulp ; Epithelium ; Chaperones ; Reticulocytes ; Immunosuppression ; Immunomodulation & Immunopharmacology;
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abstract12P < The purpose of this study was to evaluate the underlying basis for aflatoxin-induced immunosuppression in the broiler chicken by detecting pathological lesions and apoptosis in thymus, bursa of Fabricius (BF) and spleen. COBB500™ male broiler chicks were randomly allocated to two groups. The control group was fed on a basal corn-based diet while the other group (the AFB group) was fed on a similar diet but the corn was naturally contaminated with aflatoxins B 1 and B 2 . Histopathological examination revealed that in the AFB group there was more nuclear debris in the three immune organs and obvious congestion of red pulp in the spleen, when compared with the control group. Ultrastructural examination showed lesions in the lymphocytes and reticulocytes of the three immune organs, the mucosal epithelium of the BF and the plasmocytes of spleen. Increased apoptotic cells and an impaired membrane system (including nuclear membrane, mitochondria and endoplasmic reticulum) could be observed in the three immune organs in birds of the AFB group. In the plasmocytes, dilated rough endoplasmic reticulum contained electron-dense matrix. By flow cytometery, the percentages of apoptosis were asignificantly higher ( P < 0.01) in the three organs of the AFB group than those of the control group. These observations suggested that the lesions of the immune organs were related to the immunosuppression, and that the apoptosis might be initiated by the mitochondrial pathway and ER chaperone pathway.
pubTaylor & Francis
doi10.1080/03079457.2015.1023179
issue3
volume44
date2015-03-02