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Bioactive Lipids and Cationic Antimicrobial Peptides as New Potential Regulators for Trafficking of Bone Marrow-Derived Stem Cells in Patients with Acute Myocardial Infarction

Acute myocardial infarction (AMI) triggers mobilization of stem cells from bone marrow (BM) into peripheral blood (PB). Based on our observation that the bioactive sphingophospholipids, sphingosine-1 phosphate (S1P), and ceramide-1 phosphate (C1P) regulate trafficking of hematopoietic stem cells (HS... Full description

Main Author: Karapetyan, Anush V
Other Authors: Klyachkin, Yuri M , Selim, Samy , Sunkara, Manjula , Ziada, Khaled M , Cohen, Donald A , Zuba-Surma, Ewa K , Ratajczak, Janina , Smyth, Susan S , Ratajczak, Mariusz Z , Morris, Andrew J , Abdel-Latif, Ahmed
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: DOI: 10.1089/scd.2012.0488
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recordid: uky_soai_uknowledge_uky_edu_internalmedicine_facpub_1029
title: Bioactive Lipids and Cationic Antimicrobial Peptides as New Potential Regulators for Trafficking of Bone Marrow-Derived Stem Cells in Patients with Acute Myocardial Infarction
format: Article
creator:
  • Karapetyan, Anush V
  • Klyachkin, Yuri M
  • Selim, Samy
  • Sunkara, Manjula
  • Ziada, Khaled M
  • Cohen, Donald A
  • Zuba-Surma, Ewa K
  • Ratajczak, Janina
  • Smyth, Susan S
  • Ratajczak, Mariusz Z
  • Morris, Andrew J
  • Abdel-Latif, Ahmed
subjects:
  • Animals
  • Antigens
  • Antigens
  • Cd34
  • Antimicrobial Cationic Peptides
  • Bone Marrow Cells
  • Cell Hypoxia
  • Cell Movement
  • Ceramides
  • Chemokine Cxcl12
  • Glycoproteins
  • Hematopoietic Stem Cell Mobilization
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells
  • Humans
  • Lysophospholipids
  • Mice
  • Mice
  • Inbred C57bl
  • Myocardial Infarction
ispartof:
description: Acute myocardial infarction (AMI) triggers mobilization of stem cells from bone marrow (BM) into peripheral blood (PB). Based on our observation that the bioactive sphingophospholipids, sphingosine-1 phosphate (S1P), and ceramide-1 phosphate (C1P) regulate trafficking of hematopoietic stem cells (HSCs), we explored whether they also direct trafficking of non-hematopoietic stem cells (non-HSCs). We detected a 3–6-fold increase in circulating CD34+, CD133+, and CXCR4+ lineage-negative (Lin−)/CD45− cells that are enriched in non-HSCs [including endothelial progenitors (EPCs) and very small embryonic-like stem cells (VSELs)] in PB from AMI patients (P0.05 vs. controls). Concurrently, we measured a 3-fold increase in S1P and C1P levels in plasma from AMI patients. At the same time, plasma obtained at hospital admission and 6 h after AMI strongly chemoattracted human BM-derived CD34+/Lin− and CXCR4+/Lin− cells in Transwell chemotaxis assays. This effect of plasma was blunted after...
language: eng
source:
identifier: DOI: 10.1089/scd.2012.0488
fulltext: fulltext_linktorsrc
url: Link


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titleBioactive Lipids and Cationic Antimicrobial Peptides as New Potential Regulators for Trafficking of Bone Marrow-Derived Stem Cells in Patients with Acute Myocardial Infarction
creatorKarapetyan, Anush V ; Klyachkin, Yuri M ; Selim, Samy ; Sunkara, Manjula ; Ziada, Khaled M ; Cohen, Donald A ; Zuba-Surma, Ewa K ; Ratajczak, Janina ; Smyth, Susan S ; Ratajczak, Mariusz Z ; Morris, Andrew J ; Abdel-Latif, Ahmed
identifierDOI: 10.1089/scd.2012.0488
subjectAnimals ; Antigens ; Antigens ; Cd34 ; Antimicrobial Cationic Peptides ; Bone Marrow Cells ; Cell Hypoxia ; Cell Movement ; Ceramides ; Chemokine Cxcl12 ; Glycoproteins ; Hematopoietic Stem Cell Mobilization ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells ; Humans ; Lysophospholipids ; Mice ; Mice ; Inbred C57bl ; Myocardial Infarction
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0Acute myocardial infarction (AMI) triggers mobilization of stem cells from bone marrow (BM) into peripheral blood (PB). Based on our observation that the bioactive sphingophospholipids, sphingosine-1 phosphate (S1P), and ceramide-1 phosphate (C1P) regulate trafficking of hematopoietic stem cells (HSCs), we explored whether they also direct trafficking of non-hematopoietic stem cells (non-HSCs). We detected a 3–6-fold increase in circulating CD34+, CD133+, and CXCR4+ lineage-negative (Lin−)/CD45− cells that are enriched in non-HSCs [including endothelial progenitors (EPCs) and very small embryonic-like stem cells (VSELs)] in PB from AMI patients (P0.05 vs. controls). Concurrently, we measured a 3-fold increase in S1P and C1P levels in plasma from AMI patients. At the same time, plasma obtained at hospital admission and 6 h after AMI strongly chemoattracted human BM-derived CD34+/Lin− and CXCR4+/Lin− cells in Transwell chemotaxis assays. This effect of plasma was blunted after...
1Published in Stem Cells and Development, v. 22, no. 11, p. 1645-1656. This is a copy of an article published in the Stem Cells and Development (c), 2013, copyright Mary Ann Liebert, Inc.; Stem Cells and Development is available online at: a href="http://online.liebertpub.com" target="_blank"http://online.liebertpub.com/a.
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titleBioactive Lipids and Cationic Antimicrobial Peptides as New Potential Regulators for Trafficking of Bone Marrow-Derived Stem Cells in Patients with Acute Myocardial Infarction
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Acute myocardial infarction (AMI) triggers mobilization of stem cells from bone marrow (BM) into peripheral blood (PB). Based on our observation that the bioactive sphingophospholipids, sphingosine-1 phosphate (S1P), and ceramide-1 phosphate (C1P) regulate trafficking of hematopoietic stem cells (HSCs), we explored whether they also direct trafficking of non-hematopoietic stem cells (non-HSCs). We detected a 3–6-fold increase in circulating CD34+, CD133+, and CXCR4+ lineage-negative (Lin−)/CD45− cells that are enriched in non-HSCs [including endothelial progenitors (EPCs) and very small embryonic-like stem cells (VSELs)] in PB from AMI patients (P<0.05 vs. controls). Concurrently, we measured a 3-fold increase in S1P and C1P levels in plasma from AMI patients. At the same time, plasma obtained at hospital admission and 6 h after AMI strongly chemoattracted human BM-derived CD34+/Lin− and CXCR4+/Lin− cells in Transwell chemotaxis assays. This effect of plasma was blunted after...

1

Published in Stem Cells and Development, v. 22, no. 11, p. 1645-1656. This is a copy of an article published in the Stem Cells and Development (c), 2013, copyright Mary Ann Liebert, Inc.; Stem Cells and Development is available online at: http://online.liebertpub.com.

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6Cell Movement
7Ceramides
8Chemokine Cxcl12
9Glycoproteins
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titleBioactive Lipids and Cationic Antimicrobial Peptides as New Potential Regulators for Trafficking of Bone Marrow-Derived Stem Cells in Patients with Acute Myocardial Infarction
authorKarapetyan, Anush V ; Klyachkin, Yuri M ; Selim, Samy ; Sunkara, Manjula ; Ziada, Khaled M ; Cohen, Donald A ; Zuba-Surma, Ewa K ; Ratajczak, Janina ; Smyth, Susan S ; Ratajczak, Mariusz Z ; Morris, Andrew J ; Abdel-Latif, Ahmed
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9Glycoproteins
10Hematopoietic Stem Cell Mobilization
11Hematopoietic Stem Cell Transplantation
12Hematopoietic Stem Cells
13Humans
14Lysophospholipids
15Mice
16Inbred C57bl
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Acute myocardial infarction (AMI) triggers mobilization of stem cells from bone marrow (BM) into peripheral blood (PB). Based on our observation that the bioactive sphingophospholipids, sphingosine-1 phosphate (S1P), and ceramide-1 phosphate (C1P) regulate trafficking of hematopoietic stem cells (HSCs), we explored whether they also direct trafficking of non-hematopoietic stem cells (non-HSCs). We detected a 3–6-fold increase in circulating CD34+, CD133+, and CXCR4+ lineage-negative (Lin−)/CD45− cells that are enriched in non-HSCs [including endothelial progenitors (EPCs) and very small embryonic-like stem cells (VSELs)] in PB from AMI patients (P<0.05 vs. controls). Concurrently, we measured a 3-fold increase in S1P and C1P levels in plasma from AMI patients. At the same time, plasma obtained at hospital admission and 6 h after AMI strongly chemoattracted human BM-derived CD34+/Lin− and CXCR4+/Lin− cells in Transwell chemotaxis assays. This effect of plasma was blunted after...

1

Published in Stem Cells and Development, v. 22, no. 11, p. 1645-1656. This is a copy of an article published in the Stem Cells and Development (c), 2013, copyright Mary Ann Liebert, Inc.; Stem Cells and Development is available online at: http://online.liebertpub.com.

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